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Prevalence and conversion to dementia of Mild Cognitive Impairment in an elderly Italian population

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Abstract

Background

Mild Cognitive Impairment (MCI) represents a significant risk factor for dementia but there are only a few Italian population studies on its prevalence and its rate of conversion to dementia.

Aims

Aim of this study was to assess the prevalence of MCI, its subtypes, and rates of conversion to dementia 1 year later in an elderly Italian population.

Methods

The data are based on an Italian multicenter population-based cohort study with both cross-sectional and longitudinal components. Two thousand three hundred thirty-seven individuals over 65 underwent screening, clinical confirmation and 1-year follow-up.

Results

The prevalence of MCI was 21.6% and the amnestic multiple domain was the most frequent subtype (63.2%). The conversion rate to dementia was 4.1% and was found only in the amnestic multiple domain and in the unclassifiable subjects, persons with cognitive deficit but neither demented nor with MCI.

Discussion

The prevalence of MCI in this population sample was similar to that found in other population studies using Petersen’s modified MCI criteria as well as his original criteria. With regard to conversion to dementia, our results emphasize the importance to better classify the unclassifiable subjects at high risk of progression to dementia and also at risk of being undiagnosed and untreated.

Conclusion

MCI is characterized by extreme variability and instability. Data on the prevalence and the rate of conversion from MCI to dementia are difficult to compare given the important differences from study to study especially with regard to the diagnostic criteria utilized and their operationalization.

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Acknowledgements

This study was supported by a Special Program of the Ministry of Health (Special program ex art. 12, comma 2, lett B D.Lvo n. 502/92). We would like to thank the Scientific Coordinators of the Dementia Registry Study Group: Dr. Carla Grasselli, Dr. Renzo Rozzini, Dr. Salvatore Bonaiuto, Dr. Domenico Cucinotta. Thanks to Linda Inverso Moretti for assistance in editing the manuscript.

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    Authors and Affiliations

    1. National Research Council, Neuroscience Institute-Aging Branch, Via Vincenzo Maria Gallucci, 16, 35128, Padova, Italy

      Federica Limongi, Paola Siviero, Marianna Noale, Gaetano Crepaldi & Stefania Maggi

    2. Department of Medicine, University of Padua, Via Giustiniani 2, 35128, Padova, Italy

      Antonella Gesmundo

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    1. Federica Limongi
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    2. Paola Siviero
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    for the Dementia Registry Study Group

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    Correspondence to Federica Limongi.

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    Conflict of interest

    FL, PS, MN, GC work with SM, Editor in Chief of the Aging Clinical and Experimental Research.

    Ethical approval

    The study was approved by the ethics committees of the local health units of the participating centers.

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    All participants gave written informed consent.

    Additional information

    F. Limongi and P. Siviero contributed equally to the manuscript.

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    Limongi, F., Siviero, P., Noale, M. et al. Prevalence and conversion to dementia of Mild Cognitive Impairment in an elderly Italian population. Aging Clin Exp Res 29, 361–370 (2017). https://doi.org/10.1007/s40520-017-0748-1

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    • DOI: https://doi.org/10.1007/s40520-017-0748-1

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