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Lipoprotein(a) in patients with hepatocellular carcinoma and portal vein thrombosis

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Abstract

Background

The mechanism for hypercoagulability in malignancy is not entirely understood. Although several studies report contrasting finding about the link between elevated plasma levels of the lipoprotein(a) [Lp(a)] and the possible recurrence of venous thromboembolism, we perform a study to evaluate the impact of the Lp(a) in the development of portal vein thromboembolism (PVT) in patients with HCC.

Methods

We compared 44 PVT patients with 50 healthy subjects and 50 HCC patients.

Results

The comparison between PVT patients and HCC showed in the former the mean value of serum lipoprotein levels was higher than 37.3 mg/dl (p = 0.000). The comparison between PVT versus healthy controls showed that in the former, mean value of serum lipoprotein levels was higher than 75 mg/dl (p = 0.000). The predictive value test of serum lipoprotein(a) on PVT was 0.72 and on HCC was 0.83. The odds ratio of lipoprotein(a) was 9.21 on PVT and 6.33 on HCC.

Conclusion

Patients with PVT and HCC showed a statistical significant serum lipoprotein(a) level higher than the subjects with HCC and no PVT or the healthy subject. So we assume a role of lipoprotein(a) as predictor of venous thromboembolism in neoplastic patients.

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Authors and Affiliations

  1. Department of Biomedical and Biotechnological Science, University of Catania, Catania, Italy

    Giulia Malaguarnera, Michele Malaguarnera & Filippo Drago

  2. Department of Medical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of Catania, Via S. Sofia 78, 95123, Catania, Italy

    Vito Emanuele Catania & Saverio Latteri

  3. Research Center “The Great Senescence”, University of Catania, Catania, Italy

    Antonio Francaviglia

  4. Department of Experimental and Clinical Medicine, University of Catania, Catania, Italy

    Massimo Motta

Authors
  1. Giulia Malaguarnera
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  2. Vito Emanuele Catania
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  3. Antonio Francaviglia
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  4. Michele Malaguarnera
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  5. Filippo Drago
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  6. Massimo Motta
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  7. Saverio Latteri
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Corresponding author

Correspondence to Vito Emanuele Catania.

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Statement of human and animal rights

Study recruitment was performed in observation and respect of Helsinki Declaration.

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All patients gave their written informed consent for the study participation.

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Malaguarnera, G., Catania, V.E., Francaviglia, A. et al. Lipoprotein(a) in patients with hepatocellular carcinoma and portal vein thrombosis. Aging Clin Exp Res 29 (Suppl 1), 185–190 (2017). https://doi.org/10.1007/s40520-016-0653-z

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  • DOI: https://doi.org/10.1007/s40520-016-0653-z

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