Skip to main content

Advertisement

SpringerLink
Log in

Fine-needle cytology in the follow-up of breast carcinoma

  • Original Article
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

Abstract

The postoperative follow-up strategies for breast carcinoma (BC) utilize different procedures; the aim of this study was to investigate the role of fine-needle cytology (FNC) in the follow-up of BC patients. Two hundred sixty-six FNC samples from 190 BC patients have been reviewed. The target anatomical sites were 190 breast including 155 ipsilateral and 145 contralateral breast lesions and 76 extra-mammary nodules. Extra-mammary lesions included lymph nodes, thyroidal nodules, soft tissue lesions, (subcutaneous and sub-scars), salivary glands and deep located masses. Diagnostic distribution of the breast lesions was as follows: 51 positive, 15 indeterminate/suspicious, 119 negative and 5 inadequate. Positive cases included 43 ipsilateral and 8 contralateral BC, 9 BC in different quadrants from those of onset of the first BC. Sensitivity, specificity and accuracy have been 90, 91 and 90&, respectively. FNC, in a correct setting, is a reliable and effective method for the follow-up management of BC patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. National Comprehensive Cancer Network (NCCN). https://www.nccn.org/professionals/physician_gls/f_guidelines.asp

  2. Wojcinski S, Farrokh A, Hille U et al (2011) Optimizing breast cancer follow-up: diagnostic value and costs of additional routine breast ultrasound. Ultrasound Med Biol 37:198–206

    Article  PubMed  Google Scholar 

  3. Simsir A, Rapkiewicz A, Cangiarella J (2009) Current utilization of breast FNA in a cytology practice. Diagn Cytopathol 37:140–142

    Article  PubMed  Google Scholar 

  4. Manfrin E, Mariotto R, Remo A et al (2008) Is there still a role for fine-needle aspiration cytology in breast cancer screening? Experience of the Verona Mammographic Breast Cancer Screening Program with real-time integrated radiopathologic activity (1999–2004). Cancer 25:74–82

    Article  Google Scholar 

  5. Rosa M, Mohammadi A, Masood S (2012) The value of fine needle aspiration biopsy in the diagnosis and prognostic assessment of palpable breast lesions. Diagn Cytopathol 40:26–34

    Article  PubMed  Google Scholar 

  6. Tse GM, Tan PH (2010) Diagnosing breast lesions by fine needle aspiration cytology or core biopsy: which is better? Breast Cancer Res Treat 123:1–8

    Article  PubMed  Google Scholar 

  7. Kumar SK, Gupta N, Rajwanshi A et al (2012) Immunochemistry for oestrogen receptor, progesterone receptor and HER2 on cell blocks in primary breast carcinoma. Cytopathology 23:181–186

    Article  CAS  PubMed  Google Scholar 

  8. Masood S (2010) Evidence-based contributions of cytopathology to breast cancer diagnosis and research: how to sustain training and education in breast cytopathology? Breast J 16:457–459

    Article  PubMed  Google Scholar 

  9. Peluso AL, Cascone AM, Lucchese L et al (2015) Use of FTA cards for the storage of breast carcinoma nucleic acid on fine-needle aspiration samples. Cancer Cytopathol 123:582–592

    Article  CAS  PubMed  Google Scholar 

  10. Vigliar E, Cozzolino I, Fernandez LV et al (2012) Fine-needle cytology and flow cytometry assessment of reactive and lymphoproliferative processes of the breast. Acta Cytol 56:130–138

    Article  PubMed  Google Scholar 

  11. Cozzolino I, Vigliar E, Sosa Fernandez LV et al (2012) Non lymphomatous clonal B-Cell populations in enlarged lymph nodes in acquired immunodeficiency syndrome. Infez Med 20(Suppl 2):35–42

    PubMed  Google Scholar 

  12. Tauchmanovà L, Selleri C, De Rosa G et al (2005) Endocrine disorders during the first year after autologous stem-cell transplant. Am J Med 118:664–670

    Article  PubMed  Google Scholar 

  13. Tauchmanovà L, Selleri C, De Rosa G et al (2003) Gonadal status in reproductive age women after haematopoietic stem cell transplantation for haematological malignancies. Hum Reprod 18:1410–1416

    Article  PubMed  Google Scholar 

  14. Olivieri A, Cimminiello M, Corradini P et al (2013) Long-term outcome and prospective validation of NIH response criteria in 39 patients receiving imatinib for steroid-refractory chronic GVHD. Blood 122:4111–4118

    Article  CAS  PubMed  Google Scholar 

  15. Selleri C, Maciejewski JP, Montuori N et al (2003) Involvement of nitric oxide in farnesyltransferase inhibitor-mediated apoptosis in chronic myeloid leukemia cells. Blood 102:1490–1498

    Article  CAS  PubMed  Google Scholar 

  16. Rigacci L, Puccini B, Dodero A et al (2012) Allogeneic hematopoietic stem cell transplantation in patients with diffuse large B cell lymphoma relapsed after autologous stem cell transplantation: a GITMO study. Ann Hematol 91:931–939

    Article  PubMed  Google Scholar 

  17. Pelaia G, Vatrella A, Busceti MT et al (2015) Cellular mechanisms underlying eosinophilic and neutrophilic air way inflammation in asthma. Mediat Inflamm 2015:879783

    Article  Google Scholar 

  18. Pelaia G, Terracciano R, Vatrella A et al (2014) Application of proteomics and peptidomics to COPD. Biomed Res Int 2014:764581

    Article  PubMed  PubMed Central  Google Scholar 

  19. D’Amato G, Stanziola A, Sanduzzi A et al (2014) Treating severe allergic asthma with anti-IgE monoclonal antibody (omalizumab): a review. Multidiscip Respir Med 9:23

    Article  PubMed  PubMed Central  Google Scholar 

  20. Gallelli L, Busceti MT, Vatrella A et al (2013) Update on anticytokine treatment for asthma. Biomed Res Int 2013:104315

    Article  PubMed  PubMed Central  Google Scholar 

  21. Vatrella A, Montagnani S, Calabrese C et al (2010) Neuropeptide expression in the airways of COPD patients and smokers with normal lung function. J Biol Regul Homeost Agents 24:425–432

    CAS  PubMed  Google Scholar 

  22. Vatrella A, Ponticiello A, Pelaia G et al (2005) Bronchodilating effects of salmeterol, theophylline and their combination in patients with moderate to severe asthma. Pulm Pharmacol Ther 18:89–92

    Article  CAS  PubMed  Google Scholar 

  23. Fiorelli A, Mazzone S, Di Crescenzo VG et al (2014) A simple technique to control placement of Dumon stent in subglottic tracheal stenosis. Interact CardioVasc Thorac Surg 18:390–392

    Article  PubMed  Google Scholar 

  24. Di Crescenzo V, Laperuta P, Napolitano F et al (2013) An unusual case of primary choriocarcinoma of the lung. BMC Surg 13(Suppl 2):S33

    Article  PubMed  PubMed Central  Google Scholar 

  25. Di Crescenzo V, Laperuta P, Napolitano F et al (2013) Migration of surgical clips through a right lobectomy stump mimicking an asthmatic syndrome. BMC Surg 13(Suppl 2):S32

    Article  PubMed  PubMed Central  Google Scholar 

  26. Di Crescenzo V, Laperuta P, Napolitano F et al (2013) Unusual case of exacerbation of sub-acute descending necrotizing mediastinitis. BMC Surg 13(Suppl 2):S31

    Article  PubMed  Google Scholar 

  27. Di Crescenzo V, Laperuta P, Napolitano F et al (2013) Pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma. BMC Surg 13(Suppl 2):S34

    Article  PubMed  PubMed Central  Google Scholar 

  28. Santini M, Fiorelli A, Messina G et al (2013) Use of the LigaSure device and the Stapler for closure of the small bowel: a comparative ex vivo study. Surg Today 43:787–793

    Article  PubMed  Google Scholar 

  29. Fiorelli A, Petrillo M, Vicidomini G et al (2014) Quantitative assessment of emphysematous parenchyma using multidetector-row computed tomography in patients scheduled for endobronchial treatment with one-way valves†. Interact CardiovascThorac Surg 19:246–255

    Article  Google Scholar 

  30. Di Crescenzo V, Vitale M, Valvano L et al (2016) Surgical management of cervico-mediastinal goiters: our experience and review of the literature. Int J Surg 28(Suppl 1):S47–S53

    Article  PubMed  Google Scholar 

  31. Cozzolino I, Varone V, Picardi M et al (2016) CD10, BCL6, and MUM1 expression in diffuse large B-cell lymphoma on FNA samples. Cancer Cytopathol 124:135–143

    Article  CAS  PubMed  Google Scholar 

  32. Cozzolino I, Vigliar E, Todaro P et al (2014) Fine-needle aspiration cytology of lymphoproliferative lesions of the oral cavity. Cytopathology 25:241–249

    Article  CAS  PubMed  Google Scholar 

  33. Vigliar E, Cozzolino I, Picardi M et al (2014) Lymph node fine needle cytology in the staging and follow-up of cutaneous lymphomas. BMC Cancer 6:8

    Article  Google Scholar 

  34. Zeppa P, Sosa Fernandez LV, Cozzolino I et al (2012) Immunoglobulin heavy-chain fluorescence in situ hybridization-chromogenic in situ hybridization DNA probe split signal in the clonality assessment of lymphoproliferative processes on cytological samples. Cancer Cytopathol 120:390–400

    Article  PubMed  Google Scholar 

  35. Zeppa P, Barra E, Napolitano V et al (2011) Impact of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in lymph nodal and mediastinal lesions: a multicenter experience. Diagn Cytopathol 39:723–729

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Azienda Ospedaliera Universitaria AOU San Giovanni di Dio e Ruggi d’Aragona, University of Salerno, Largo Città d’Ippocrate n.1, 84100, Salerno, Italy

    Anna Maria Cascone, Maria Siano, Basilio Angrisani, Rosa Maria Di Crescenzo, Alessandro Vatrella, Carmine Selleri, Francesco Salzano & Pio Zeppa

Authors
  1. Anna Maria Cascone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maria Siano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Basilio Angrisani
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Rosa Maria Di Crescenzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alessandro Vatrella
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Carmine Selleri
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Francesco Salzano
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Pio Zeppa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Pio Zeppa.

Ethics declarations

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Statement of human and animal rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study formal consent is not required.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cascone, A.M., Siano, M., Angrisani, B. et al. Fine-needle cytology in the follow-up of breast carcinoma. Aging Clin Exp Res 29 (Suppl 1), 167–171 (2017). https://doi.org/10.1007/s40520-016-0645-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40520-016-0645-z

Keyword

Search

Navigation