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Association of the COL1A1 gene polymorphisms in Mexican postmenopausal women with fracture or with low bone mineral density at the hip

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Abstract

Background and aims

Osteoporosis leads to high fracture risk and evidence suggests that genetic factors play an important role in this disease. The aim was to evaluate the association of two polymorphisms (−1997G/T, +1245G/T) in the collagen type1 alpha 1 gene (COL1A1) with fracture or with low bone mineral density (BMD) at the hip in postmenopausal Mexican women.

Methods

BMD was determined by bone densitometry and the risk factors were collected with a questionnaire. Genotyping was performed by real-time PCR.

Results

The polymorphisms were in Hardy–Weinberg equilibrium. The −1997G/+1245T haplotype showed, after adjustment for confounders, a fourfold increased risk of hip fracture [OR 4.32; p = 0.041 (95 % CI 1.07–17.43)]; while in the women with low BMD at the hip, the risk was increased threefold [OR 3.36; p = 0.022 (95 % CI 1.20–9.40)].

Conclusions

The results support the association of COL1A1 gene polymorphisms with fracture and with low BMD at the hip in Mexican population.

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Acknowledgments

This work was supported by Consejo Nacional de Ciencia y Tecnología. Project: CONACYT-SALUD- C01-69706.

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Authors and Affiliations

  1. Departamento de Genética, Instituto Nacional de Rehabilitación, Calzada México-Xochimilco No. 289, Arenal de Guadalupe, Tlalpan, 14389, Mexico City, Mexico

    Edith Falcón-Ramírez, Alberto Hidalgo-Bravo, Blanca Alicia Barredo-Prieto & Margarita Valdés-Flores

  2. Servicio de Traumatología, Instituto Nacional de Rehabilitación, Mexico City, Mexico

    Ernesto Pineda-Gómez

Authors
  1. Edith Falcón-Ramírez
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  2. Alberto Hidalgo-Bravo
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  3. Blanca Alicia Barredo-Prieto
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  4. Ernesto Pineda-Gómez
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  5. Margarita Valdés-Flores
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Corresponding author

Correspondence to Margarita Valdés-Flores.

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Funding

This work was supported by Consejo Nacional de Ciencia y Tecnología. Project: CONACYT-SALUD-C01-69706.

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with ethical standards of the institutional committee and with the 1964 Helsinki declaration and its later amendments. This study was approved by the Ethics Committee of the National Rehabilitation Institute.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Falcón-Ramírez, E., Hidalgo-Bravo, A., Barredo-Prieto, B.A. et al. Association of the COL1A1 gene polymorphisms in Mexican postmenopausal women with fracture or with low bone mineral density at the hip. Aging Clin Exp Res 28, 567–571 (2016). https://doi.org/10.1007/s40520-015-0449-6

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  • DOI: https://doi.org/10.1007/s40520-015-0449-6

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