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Aging Clinical and Experimental Research

, Volume 28, Issue 1, pp 165–166 | Cite as

Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials

  • Xiao-Wei Zhang
  • Wen-Shang Hou
  • Min Li
  • Zhen-Yu TangEmail author
Short Communication

Abstract

Evidence has demonstrated that omega-3 fatty acids intake may be associated with age-related cognitive decline. However, randomized controlled trials (RCTs) have drawn inconsistent conclusions. We performed a meta-analysis to assess the association between omega-3 fatty acids and risk of cognitive decline in the elderly. A strategic literature search of PubMed, EMBASE, and Cochrane Library (updated to December 2014) was performed. We retrieved six randomized controlled studies as eligible for our meta-analysis. Among these six studies, the duration time ranged from 3 to 40 months. The dose of omega-3 fatty acids (DHA + EPA) ranged from 400 to 1800 mg. The result of our meta-analysis expressed that omega-3 fatty acids statistically decrease the rate of cognitive decline in MMSE score (WMD = 0.15, [0.05, 0.25]; p = 0.003). In conclusion, our meta-analysis indicated that omega-3 fatty acids may help to prevent cognitive decline in the elderly.

Keywords

Omega-3 fatty acids Cognitive decline Randomized controlled trial Meta-analysis 

Notes

Acknowledgments

The following authors contributed substantially to conception and design (X.W. Zhang, Z.Y. Tang), data collection (W.S. Hou, M. Li), analyses and presentation of data (X. W. Zhang). All authors had full access to the data and take responsibility for their integrity. All authors agree with the manuscript as written.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

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References

  1. 1.
    Waitzberg DL, Garla P (2014) Contribution of omega-3 fatty acids for memory and cognitive function. Nutr Hosp 30(3):467–477PubMedGoogle Scholar
  2. 2.
    Hooijmans CR, Kiliaan AJ (2008) Fatty acids, lipid metabolism and Alzheimer pathology. Eur J Pharmacol 585(1):176–196CrossRefPubMedGoogle Scholar
  3. 3.
    Uauy R, Dangour AD (2006) Nutrition in brain development and aging: role of essential fatty acids. Nutr Rev 64(5 Pt 2):S24–S33 discussion S72–S91 CrossRefPubMedGoogle Scholar
  4. 4.
    Rondanelli M, Opizzi A, Faliva M et al (2012) Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. Nutr Neurosci 15:46–54CrossRefPubMedGoogle Scholar
  5. 5.
    Geleijnse JM, Giltay EJ, Kromhout D (2012) Effects of n-3 fatty acids on cognitive decline: a randomized, double-blind, placebo-controlled trial in stable myocardial infarction patients. Alzheimers Dement 8:278–287CrossRefPubMedGoogle Scholar
  6. 6.
    Lee LK, Shahar S, Chin AV et al (2013) Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, doubleblind, placebo-controlled trial. Psychopharmacology (Berl) 225:605–612CrossRefGoogle Scholar
  7. 7.
    Yurko-Mauro K, McCarthy D, Rom D et al (2010) Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement 6:456–464CrossRefPubMedGoogle Scholar
  8. 8.
    Chiu CC, Su KP, Cheng TC et al (2008) The effects of omega-3 fatty acids monotherapy in Alzheimer’s disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study. Prog Neuropsychopharmacol Biol Psychiatry 32:1538–1544CrossRefPubMedGoogle Scholar
  9. 9.
    Freund-Levi Y, Eriksdotter-Jonhagen M, Cederholm T et al (2006) Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: omegAD study: a randomized double-blind trial. Arch Neurol 63:1402–1408CrossRefPubMedGoogle Scholar
  10. 10.
    Dangour AD, Allen E, Elbourne D et al (2010) Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial. Am J Clin Nutr 91:1725–1732CrossRefPubMedGoogle Scholar
  11. 11.
    Stough C, Downey L, Silber B et al (2012) The effects of 90-day supplementation with the omega-3 essential fatty acid docosahexaenoic acid (DHA) on cognitive function and visual acuity in a healthy aging population. Neurobiol Aging 33:824CrossRefPubMedGoogle Scholar
  12. 12.
    Shinto L, Quinn J, Montine T et al (2014) A Randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer’s disease. J Alzheimers Dis 38(1):111–120PubMedGoogle Scholar
  13. 13.
    Dyall SC, Michael GJ, Michael-Titus AT (2010) Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J Neurosci Res 88(10):2091–2102CrossRefPubMedGoogle Scholar
  14. 14.
    Robson LG, Dyall S, Sidloff D et al (2010) Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiol Aging 31(4):678–687CrossRefPubMedGoogle Scholar
  15. 15.
    Cutuli D, De Bartolo P, Caporali P et al (2014) n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice. Front Aging Neurosci 6:220PubMedCentralCrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Xiao-Wei Zhang
    • 1
  • Wen-Shang Hou
    • 1
  • Min Li
    • 1
  • Zhen-Yu Tang
    • 1
    Email author
  1. 1.Department of NeurologyThe Second Affiliated Hospital of Nanchang UniversityNanchangPeople’s Republic of China

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