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Classification of pro-inflammatory status for interleukin-6 affects relative muscle strength in obese elderly women

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Abstract

Background

Obesity, defined by an excess amount of body fat or a percent body fat higher than 30 % for women is a complex chronic disorder with multifactorial etiology and is accompanied by chronic low-grade inflammation, which results in elevated pro-inflammatory cytokines.

Aims

The aim of this study was to compare muscle strength between high and low pro-inflammatory status in obese elderly women and to verify the relationship of IL-6 with muscle strength and fat-free mass.

Methods

Eighty-nine elderly women (age 69.47 ± 6.07 years; body mass 64.70 ± 12.04 kg; height 1.52 ± 0.06 m; body mass index 27.78 ± 4.75 kg/m2) were divided into two groups: high and low inflammatory status for IL-6. Lower limb muscle strength was tested using bilateral leg extension with the ten repetitions maximum test, IL-6 was measured by ELISA and body composition by dual-energy X-ray absorptiometry.

Results

Women classified from the high pro-inflammatory status presented lower relative muscle strength (P = 0.056) when compared with the low inflammatory status group, with no differences for absolute muscle strength (P = 0.18). There was a significant negative correlation of IL-6 with relative muscle strength (P = 0.03, R = −0.22) and a considerable trend toward significance (P = 0.06, R = −0.19) and negative association with fat-free mass (P = 0.84, R = −0.02).

Conclusions

This study provides insights that a high pro-inflammatory status in sedentary obese elderly women might impair muscle strength and negatively affect fat-free mass. Thus, elderly women classified with high pro-inflammatory status for IL-6 should receive further health care attention to prevent this deleterious condition.

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References

  1. Han TS, Tajar A, Lean ME (2011) Obesity and weight management in the elderly. Br Med Bull 97:169–196. doi:10.1093/bmb/ldr002

    Article  CAS  PubMed  Google Scholar 

  2. National Institutes of Health (2001) Understanding adult obesity—National Institute of Diabetes and Digestive and Kidney Diseases. http://win.niddk.nih.gov/publications/PDFs/adultobesbw1201.pdf. Accessed 08 Dec 2014

  3. WHO (2014) Obesity and overweight. http://www.who.int/mediacentre/factsheets/fs311/en/. Accessed 08 Dec 2014

  4. Vigitel—Vigilância de Fatores de Risco e Proteção para Doenças Crônicas por Inquérito Telefônico (2013). http://portalsaude.saude.gov.br/images/pdf/2014/abril/30/Lancamento-Vigitel-28-04-ok.pdf. Accessed 08 Dec 2014

  5. Lee H, Lee IS, Choue R (2013) Obesity, inflammation and diet. Pediatr Gastroenterol Hepatol Nutr 16:143–152. doi:10.5223/pghn.2013.16.3.143

    Article  PubMed Central  PubMed  Google Scholar 

  6. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B (2006) Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17:4–12

    CAS  PubMed  Google Scholar 

  7. Nicklas BJ, Brinkley TE (2009) Exercise training as a treatment for chronic inflammation in the elderly. Exerc Sport Sci Rev 37:165–170. doi:10.1097/JES.0b013e3181b7b3d9

    PubMed Central  PubMed  Google Scholar 

  8. Addison O, LaStayo PC, Dibble LE, Marcus RL (2012) Inflammation, aging, and adiposity: implications for physical therapists. J Geriatr Phys Ther 35:86–94. doi:10.1519/JPT.0b013e3182312b14

    Article  PubMed  Google Scholar 

  9. Anker SD, Ponikowski PP, Clark AL, Leyva F, Rauchhaus M, Kemp M, Teixeira MM, Hellewell PG, Hooper J, Poole-Wilson PA, Coats AJ (1999) Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure. Eur Heart J 20:683–693. doi:10.1053/euhj.1998.1446

    Article  CAS  PubMed  Google Scholar 

  10. Goodman MN (1994) Interleukin-6 induces skeletal muscle protein breakdown in rats. Proc Soc Exp Biol Med 205:182–185. doi:10.3181/00379727-205-43695

    Article  CAS  PubMed  Google Scholar 

  11. Visser M, Pahor M, Taaffe DR, Goodpaster BH, Simonsick EM, Newman AB, Nevitt M, Harris TB (2002) Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci 57:M326–M332. doi:10.1093/gerona/57.5.M326

    Article  PubMed  Google Scholar 

  12. Taaffe DR, Harris TB, Ferrucci L, Rowe J, Seeman TE (2000) Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol A Biol Sci Med Sci 55:M709–M715. doi:10.1093/gerona/55.12.M709

    Article  CAS  PubMed  Google Scholar 

  13. Funghetto SS, Prestes J, Silva Ade O, Farias DL, Teixeira TG, Vieira DC, Souza VC, Sousa NM, Navalta JW, Melo GF, Karnikowski MG (2013) Interleukin-6 -174G/C gene polymorphism affects muscle damage response to acute eccentric resistance exercise in elderly obese women. Exp Gerontol 48:1255–1259. doi:10.1016/j.exger.2013.08.009

    Article  PubMed  Google Scholar 

  14. Prestes J, Tibana RA (2013) Muscular static strength test performance and health: absolute or relative values? Rev Assoc Med Bras 59:308–309. doi:10.1016/j.ramb.2013.01.009

    Article  PubMed  Google Scholar 

  15. Frontera WR, Hughes VA, Fielding RA, Fiatarone MA, Evans WJ, Roubenoff R (2000) Aging of skeletal muscle: a 12-year longitudinal study. J Appl Physiol (1985) 88:1321–1326

    CAS  Google Scholar 

  16. Field AP (2013) Discovering statistics using IBM SPSS statistics: and sex and drugs and rock ‘n’ roll, 4th edn. Sagepublications, London

    Google Scholar 

  17. Penninx BW, Kritchevsky SB, Newman AB, Nicklas BJ, Simonsick EM, Rubin S, Nevitt M, Visser M, Harris T, Pahor M (2004) Inflammatory markers and incident mobility limitation in the elderly. J Am Geriatr Soc 52:1105–1113. doi:10.1111/j.1532-5415.2004.52308.x

    Article  PubMed  Google Scholar 

  18. Ferrucci L, Penninx BW, Volpato S, Harris TB, Bandeen-Roche K, Balfour J, Leveille SG, Fried LP, Md JM (2002) Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. J Am Geriatr Soc 50:1947–1954. doi:10.1046/j.1532-5415.2002.50605.x

    Article  PubMed  Google Scholar 

  19. Faul F, Erdfelder E, Lang AG, Buchner A (2007) G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39:175–191

    Article  PubMed  Google Scholar 

  20. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA (2011) The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 11:607–615. doi:10.1038/nri3041

    Article  CAS  PubMed  Google Scholar 

  21. Barbieri M, Ferrucci L, Ragno E, Corsi A, Bandinelli S, Bonafè M, Olivieri F, Giovagnetti S, Franceschi C, Guralnik JM, Paolisso G (2003) Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab 3:E481–E487. doi:10.1152/ajpendo.00319.2002

    Article  Google Scholar 

  22. Westcott WL (2012) Resistance training is medicine: effects of strength training on health. Curr Sports Med Rep 11:209–216. doi:10.1249/JSR.0b013e31825dabb8

    Article  PubMed  Google Scholar 

  23. Kraemer WJ, Ratamess NA, French DN (2002) Resistance training for health and performance. Curr Sports Med Rep 1:165–171

    Article  PubMed  Google Scholar 

  24. Prestes J, Shiguemoto G, Botero JP, Frollini A, Dias R, Leite R, Pereira G, Magosso R, Baldissera V, Cavaglieri C, Perez S (2009) Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post-menopausal women. J Sports Sci 27:1607–1615. doi:10.1080/02640410903352923

    Article  PubMed  Google Scholar 

  25. Fisher G, Bickel CS, Hunter GR (2014) Elevated circulating TNF-alpha in fat-free mass non-responders compared to responders following exercise training in older women. Biology (Basel) 3:551–559. doi:10.3390/biology3030551

    CAS  Google Scholar 

  26. Sampson JA, McAndrew D, Donohoe A, Jenkins A, Groeller H (2013) The effect of a familiarisation period on subsequent strength gain. J Sports Sci 31:204–211. doi:10.1080/02640414.2012.725134

    Article  PubMed  Google Scholar 

  27. Mann TN, Lamberts RP, Lambert MI (2014) High responders and low responders: factors associated with individual variation in response to standardized training. Sports Med 44:1113–1124. doi:10.1007/s40279-014-0197-3

    Article  PubMed  Google Scholar 

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Acknowledgments

This research was supported by the National Council of Scientific and Technological Development—CNPq (483549/2011-8). The authors have no conflicts of interest that are directly relevant to the content of this manuscript. In addition, the first author wants to dedicate this paper to his family (Rita de Cassia and Nicolas Cunha).

Conflict of interest

The authors declare no conflict of interest in this paper.

Ethical approval

The study was approved by the Institutional Research Ethics Committee (protocol #035/2011). Study design and employed procedures are in accordance with ethical standards and the Declaration of Helsinki.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Author information

Authors and Affiliations

  1. Graduation Program on Physical Education, Catholic University of Brasilia, Q.S. 07, Lote 01, EPTC, Bloco G, Taguatinga, Federal District, Brasilia, 71966-700, Brazil

    Dahan da Cunha Nascimento, Ivo Vieira de Sousa Neto, Ramires Alsamir Tibana, Vinicius Carolino de Souza, Denis Cesar Leite Vieira, Nathalia Ferreira Camarço, Sandra de Oliveira & Jonato Prestes

  2. UDF - Centro Universitário, Brasilia, DF, Brazil

    Dahan da Cunha Nascimento & Denis Cesar Leite Vieira

  3. Laboratory of Exercise Physiology, Faculty Estacio of Vitoria, Vitoria, ES, Brazil

    Nuno Manuel Frade de Sousa

  4. Graduation Program in Gerontology, Catholic University of Brasilia, Brasilia, Brazil

    Vinicius Carolino de Souza

  5. Graduation Program in Medical Sciences, University of Brasilia, Brasilia, Brazil

    Vinicius Carolino de Souza

  6. Departamento de Educação Física, Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, Brazil

    Jeeser Alves de Almeida

  7. Department of Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, NV, USA

    James Navalta

Authors
  1. Dahan da Cunha Nascimento
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  2. Nuno Manuel Frade de Sousa
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  3. Ivo Vieira de Sousa Neto
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  4. Ramires Alsamir Tibana
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  5. Vinicius Carolino de Souza
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  6. Denis Cesar Leite Vieira
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  7. Nathalia Ferreira Camarço
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  8. Sandra de Oliveira
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  9. Jeeser Alves de Almeida
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  10. James Navalta
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  11. Jonato Prestes
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Corresponding author

Correspondence to Dahan da Cunha Nascimento.

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da Cunha Nascimento, D., de Sousa, N.M.F., de Sousa Neto, I.V. et al. Classification of pro-inflammatory status for interleukin-6 affects relative muscle strength in obese elderly women. Aging Clin Exp Res 27, 791–797 (2015). https://doi.org/10.1007/s40520-015-0349-9

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  • DOI: https://doi.org/10.1007/s40520-015-0349-9

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