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Alleviation of podocyte injury: the possible pathway implicated in anti-inflammation of alpha-lipoic acid in type 2 diabetics

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Abstract

Background and aims

The objective of this study is to observe the effect of alpha-lipoic acid (ALA) on Pod injury by anti-inflammation and explore its possible renal protective mechanism.

Methods

A total of 36 cases with type 2 diabetes with microalbuminuria and fasting plasma glucose (FPG) levels less than 9 mmol/L and glycated hemoglobin A1c (HbA1c) ≤9.0 % were recruited to be treated with ALA (600 mg, daily) for 6 months (group DA). Another 30 healthy individuals were chosen as normal controls (group NC). The levels of serum creatinine (Cr), FPG, and HbA1c were detected; blood pressure was recorded; and early morning urine samples (corrected for urinary Cr) were collected for the examination of urinary monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-β1 (TGF-β1), podocalyxin (PCX), nephrin, albumin and Cr in group NC and group DA at the baseline and the sixth month.

Results

The excretions of urinary MCP-1, TGF-β1, PCX, nephrin and albumin to Cr ratio (abbreviated as UMCR, UTCR, UPCR, UNCR and UACR respectively) were significantly increased in group DA compared with group NC (all P < 0.01), and after 6-month treatment, all indexes mentioned above decreased markedly (P < 0.05), while FPG and HbA1c had no obvious changes. Additionally, there was a positive correlation between UMCR, UTCR with UPCR, UNCR and UACR, respectively (all P < 0.01).

Conclusions

Anti-inflammation of ALA in vivo and local kidney is implicated in the protection of glomerular Pod injury in patients with type 2 diabetes.

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Acknowledgments

This research was supported by the natural science foundation (No. 11040606M159) and natural science research project (No. KJ2011A157) of Anhui Province of China. Great help was offered by the Department of Endocrinology of Anhui Provincial Hospital affiliated to Anhui Medical University of China.

Conflict of interest

The authors state that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, 230001, China

    Xi-He Bao, Jiang Xu & Shan-Dong Ye

  2. Endocrinological Laboratory of Anhui Provincial Hospital, Hefei, 230001, China

    Yan Chen

  3. Biochemistry Laboratory of Anhui Provincial Hospital, Hefei, 230001, China

    Chun-Lin Yang

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  1. Xi-He Bao
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  2. Jiang Xu
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  3. Yan Chen
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Correspondence to Shan-Dong Ye.

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Bao, XH., Xu, J., Chen, Y. et al. Alleviation of podocyte injury: the possible pathway implicated in anti-inflammation of alpha-lipoic acid in type 2 diabetics. Aging Clin Exp Res 26, 483–489 (2014). https://doi.org/10.1007/s40520-014-0207-1

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  • DOI: https://doi.org/10.1007/s40520-014-0207-1

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