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Oxidative stress and aging: correlation with clinical parameters

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Abstract

Background and aims

The free radical theory of aging has been receiving a lot of attention in the past years. The aim of this study was to examine the correlation between oxidative damage, antioxidant enzyme activities and plasma antioxidant potential with clinical parameters in elderly people.

Methods

Elderly subjects over 80 years old were included in the study. Clinical data were collected based on the Cumulative Illness Rating Scale (n = 132). In addition, blood samples were collected to determine biochemical and oxidative stress.

Results

The results showed that the mean age of the participants was 85.1 ± 4.0 years old. Diabetic patients presented higher plasma protein carbonyl levels when compared with non-diabetic, and plasma levels of thiobarbituric acid-reactive substances were correlated to serum triglyceride and LDL fraction. In contrast, a lower plasma total antioxidant capacity presented a relation with the presence of diabetes and arterial hypertension. In addition, healthy elderly subjects presented a higher plasma total antioxidant capacity.

Conclusion

Thus, it seemed that plasma antioxidant potential is a better predictor of successful aging in the elderly than oxidative damage parameters or plasma antioxidant enzyme activities.

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Authors and Affiliations

  1. Laboratório de Fisiopatologia Experimental and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil

    Ana Carla da Cruz, Fabricia Petronilho, Claudia Cipriano Vidal Heluany, Francieli Vuolo & Felipe Dal-Pizzol

  2. Programa de Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, Tubarão, SC, Brazil

    Fabricia Petronilho & Samantha Pereira Miguel

  3. Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil

    João Quevedo

  4. Laboratório de Neurociências, Departamento de Saúde Mental, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Marco Aurélio Romano-Silva

Authors
  1. Ana Carla da Cruz
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  2. Fabricia Petronilho
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  3. Claudia Cipriano Vidal Heluany
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  4. Francieli Vuolo
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  5. Samantha Pereira Miguel
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  6. João Quevedo
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  7. Marco Aurélio Romano-Silva
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  8. Felipe Dal-Pizzol
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Corresponding author

Correspondence to Felipe Dal-Pizzol.

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da Cruz, A.C., Petronilho, F., Heluany, C.C.V. et al. Oxidative stress and aging: correlation with clinical parameters. Aging Clin Exp Res 26, 7–12 (2014). https://doi.org/10.1007/s40520-013-0176-9

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  • DOI: https://doi.org/10.1007/s40520-013-0176-9

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