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Brain activation during dual-task walking and executive function among older adults with mild cognitive impairment: a fNIRS study

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Abstract

Background and aims

Dual-task walking (DTW) is thought to involve activation of the prefrontal cortex in healthy adults and to be affected by cognitive impairment. However, it is unclear whether prefrontal cortex activation is involved in DTW in older adults with mild cognitive impairment. This study examined brain activation during DTW among older adults with mild cognitive impairment using functional near-infrared spectroscopy.

Methods

Sixteen older adults (aged 75.4 ± 7.2 years, women n = 6) performed gait experiments under normal walking and DTW conditions. We used a design with 60-s blocks consisting of a 10-s rest standing as pre-resting period, a 20-s walking task period, and a 30-s rest standing as post-resting period. Walking speed was measured during a 20-s walking task. Changes in oxy-hemoglobin were measured in the prefrontal area during gait experiments.

Results

Walking speed was slower during DTW compared with normal walking (p < 0.001). The oxy-hemoglobin level during DTW was higher than during normal walking (p < 0.001) and was correlated with executive function, as measured by Stroop interference (p < 0.05).

Conclusion

Our findings indicate that DTW is associated with prefrontal activation among older adults with mild cognitive impairment. The brain activation during DTW was correlated with executive function. Additional studies are necessary to elucidate the effects of cognitive impairment on the association between prefrontal activity and walking under various conditions.

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References

  1. Al-Yahya E, Dawes H, Smith L, Dennis A, Howells K, Cockburn J (2011) Cognitive motor interference while walking: a systematic review and meta-analysis. Neurosci Biobehav Rev 35:715–728

    Article  PubMed  Google Scholar 

  2. Woollacott M, Shumway-Cook A (2002) Attention and the control of posture and gait: a review of an emerging area of research. Gait Posture 16:1–14

    Article  PubMed  Google Scholar 

  3. Yogev-Seligmann G, Hausdorff JM, Giladi N (2008) The role of executive function and attention in gait. Mov Disord 23: 329–342 (quiz 472)

    Google Scholar 

  4. Hausdorff JM, Schweiger A, Herman T, Yogev-Seligmann G, Giladi N (2008) Dual-task decrements in gait: contributing factors among healthy older adults. J Gerontol A Biol Sci Med Sci 63:1335–1343

    Article  PubMed  Google Scholar 

  5. Herman T, Mirelman A, Giladi N, Schweiger A, Hausdorff JM (2010) Executive control deficits as a prodrome to falls in healthy older adults: a prospective study linking thinking, walking, and falling. J Gerontol A Biol Sci Med Sci 65:1086–1092

    Article  PubMed  Google Scholar 

  6. Sheridan PL, Solomont J, Kowall N, Hausdorff JM (2003) Influence of executive function on locomotor function: divided attention increases gait variability in Alzheimer’s disease. J Am Geriatr Soc 51:1633–1637

    Article  PubMed  Google Scholar 

  7. Muir SW, Speechley M, Wells J, Borrie M, Gopaul K, Montero-Odasso M (2012) Gait assessment in mild cognitive impairment and Alzheimer’s disease: the effect of dual-task challenges across the cognitive spectrum. Gait Posture 35:96–100

    Article  PubMed  Google Scholar 

  8. Pettersson AF, Olsson E, Wahlund LO (2005) Motor function in subjects with mild cognitive impairment and early Alzheimer’s disease. Dement Geriatr Cogn Disord 19:299–304

    Article  PubMed  CAS  Google Scholar 

  9. Gillain S, Warzee E, Lekeu F et al (2009) The value of instrumental gait analysis in elderly healthy, MCI or Alzheimer’s disease subjects and a comparison with other clinical tests used in single and dual-task conditions. Ann Phys Rehabil Med 52:453–474

    Article  PubMed  CAS  Google Scholar 

  10. Petersen RC (2004) Mild cognitive impairment as a diagnostic entity. J Intern Med 256:183–194

    Article  PubMed  CAS  Google Scholar 

  11. Verghese J, Wang C, Lipton RB, Holtzer R, Xue X (2007) Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry 78:929–935

    Article  PubMed  Google Scholar 

  12. Yamada M, Tanaka B, Nagai K, Aoyama T, Ichihashi N (2010) Trail-walking exercise and fall risk factors in community-dwelling older adults: preliminary results of a randomized controlled trial. J Am Geriatr Soc 58:1946–1951

    Article  PubMed  Google Scholar 

  13. Holtzer R, Mahoney JR, Izzetoglu M, Izzetoglu K, Onaral B, Verghese J (2011) Fnirs study of walking and walking while talking in young and old individuals. J Gerontol A Biol Sci Med Sci 66:879–887

    Article  PubMed  Google Scholar 

  14. la Fougere C, Zwergal A, Rominger A et al (2010) Real versus imagined locomotion: a f-18 -fdg pet-fmri comparison. Neuroimage 50:1589–1598

    Article  PubMed  Google Scholar 

  15. Hanakawa T, Katsumi Y, Fukuyama H et al (1999) Mechanisms underlying gait disturbance in Parkinson’s disease: a single photon emission computed tomography study. Brain 122(Pt 7):1271–1282

    Article  PubMed  Google Scholar 

  16. Miyai I, Tanabe HC, Sase I et al (2001) Cortical mapping of gait in humans: a near-infrared spectroscopic topography study. Neuroimage 14:1186–1192

    Article  PubMed  CAS  Google Scholar 

  17. Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198

    Article  PubMed  CAS  Google Scholar 

  18. Makizako H, Shimada H, Doi T et al (2011) The association between decline in physical functioning and atrophy of medial temporal areas in community-dwelling older adults with amnestic and nonamnestic mild cognitive impairment. Arch Phys Med Rehabil 92: 1992–1999

    Google Scholar 

  19. Alvarez JA, Emory E (2006) Executive function and the frontal lobes: a meta-analytic review. Neuropsychol Rev 16:17–42

    Article  PubMed  Google Scholar 

  20. Kato M (2001) Prefrontal lobes and the attentional control: a neuropsychological study using modified stroop test. Clin Neurol (Rinsho shinkeigaku) 41:1134–1136

    CAS  Google Scholar 

  21. Takahashi T, Takikawa Y, Kawagoe R, Shibuya S, Iwano T, Kitazawa S (2011) Influence of skin blood flow on near-infrared spectroscopy signals measured on the forehead during a verbal fluency task. Neuroimage 57:991–1002

    Article  PubMed  Google Scholar 

  22. Holtzer R, Mahoney JR, Izzetoglu M, Izzetoglu K, Onaral B, Verghese J (2011) fNIRS study of walking and walking while talking in young and old individuals. J Gerontol Ser A-Biol Sci Med Sci 66:879–887

    Article  Google Scholar 

  23. Wobst P, Wenzel R, Kohl M, Obrig H, Villringer A (2001) Linear aspects of changes in deoxygenated hemoglobin concentration and cytochrome oxidase oxidation during brain activation. Neuroimage 13:520–530

    Article  PubMed  CAS  Google Scholar 

  24. Kita Y, Gunji A, Inoue Y et al (2011) Self-face recognition in children with autism spectrum disorders: a near-infrared spectroscopy study. Brain Dev 33:494–503

    Article  PubMed  Google Scholar 

  25. Yamamoto T, Kato T (2002) Paradoxical correlation between signal in functional magnetic resonance imaging and deoxygenated haemoglobin content in capillaries: a new theoretical explanation. Phys Med Biol 47:1121–1141

    Article  PubMed  CAS  Google Scholar 

  26. Strangman G, Franceschini MA, Boas DA, Yamamoto T, Kato T (2003) Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters paradoxical correlation between signal in functional magnetic resonance imaging and deoxygenated haemoglobin content in capillaries: a new theoretical explanation. Neuroimage 18:865–879

    Article  PubMed  Google Scholar 

  27. Verghese J, Robbins M, Holtzer R et al (2008) Gait dysfunction in mild cognitive impairment syndromes. J Am Geriatr Soc 56:1244–1251

    Article  PubMed  Google Scholar 

  28. Leon-Carrion J, Damas-Lopez J, Martin-Rodriguez JF et al (2008) The hemodynamics of cognitive control: the level of concentration of oxygenated hemoglobin in the superior prefrontal cortex varies as a function of performance in a modified stroop task. Behav Brain Res 193:248–256

    Article  PubMed  CAS  Google Scholar 

  29. Schroeter ML, Zysset S, Wahl M, von Cramon DY (2004) Prefrontal activation due to stroop interference increases during development–an event-related fNIRS study. Neuroimage 23:1317–1325

    Article  PubMed  Google Scholar 

  30. Dickerson BC, Sperling RA (2008) Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer’s disease: insights from functional MRI studies. Neuropsychologia 46:1624–1635

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

We would like to thank the Obu city office for help with participant recruitment. This work was supported by a grant from the Japanese Ministry of Health, Labour and Welfare and Grant-in-Aid for Research Activity Start-up (22800093) to T.D. in Japan.

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Correspondence to Takehiko Doi.

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Doi, T., Makizako, H., Shimada, H. et al. Brain activation during dual-task walking and executive function among older adults with mild cognitive impairment: a fNIRS study. Aging Clin Exp Res 25, 539–544 (2013). https://doi.org/10.1007/s40520-013-0119-5

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  • DOI: https://doi.org/10.1007/s40520-013-0119-5

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