Skip to main content
SpringerLink
Log in

Autograft, allograft and bone substitutes in reconstructive orthopedic surgery

  • Short Communication
  • Published:
Aging Clinical and Experimental Research Aims and scope Submit manuscript

Abstract

Reconstruction of bone defects is a challenge for all orthopedic surgeons worldwide; to overcome this problem there are different options: the use of autografts, allografts and bone substitutes (BSs) to enhance and accelerate bone repair. Autografts have excellent biological properties but are associated with morbidity of the donor site and are restricted in volume. Allografts are available in adequate quantity but concerns still remain about the risk of infections, moreover they do not have osteogenetic properties. Bone substitutes have different indications and are very attractive for orthopedic surgeons. The present paper briefly reviews the advantages and disadvantages of autografts, allografts and BSs for bone reconstruction.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Miron RJ, Zhang YF (2012) Osteoinduction: a review of old concepts with new standards. J Dent Res 91(8):736–744. doi:10.1177/0022034511435260

    Article  PubMed  CAS  Google Scholar 

  2. Bhatt RA, Rozental TD (2012) Bone graft substitutes. Hand Clin 28(4):457–468. doi:10.1016/j.hcl.2012.08.001

    Article  PubMed  Google Scholar 

  3. Pape HC, Evans A, Kobbe P (2010) Autologous bone graft: properties and techniques. J Orthop Trauma 24(suppl 1):S36–S40. doi:10.1097/BOT.0b013e3181cec4a1

    Article  PubMed  Google Scholar 

  4. Fernandez-Bances I, Perez-Basterrechea M, Perez-Lopez S, Nunez batalla D, Fernandez Rodriguez MA, Alvarez-Viejo M, Ferrero-Gutierrez A, Menendez–Menendez Y, Garcia-Gala JM, Escudero D, Paz Aparicio J, Carnero Lopez S, Lopez Fernandez P, Gonzales Suarez D, Otero Hernandez J (2013) Repair of long-bone pseudoarthrosis with autologous bone marrow mononuclear cell combined with allogenic bone graft. Cytotherapy 15(5):571–577. doi:10.1016/j.jcyt.2013.01.004

    Article  PubMed  CAS  Google Scholar 

  5. Khan SN, Cammisa FP Jr, Sandhu HS, Diwan AD, Girardi FP, Lane JM (2005) The biology of bone grafting. J Am Acad Orthop Surg 13(1):77–86

    PubMed  Google Scholar 

  6. Palmer W, Crawford-Sykes A, Rose RE (2008) Donor site morbidity following iliac crest bone graft. West Indian Med J 57(5):490–492

    PubMed  CAS  Google Scholar 

  7. Goff T, Kanakaris NK, Giannoudis PV (2013) Use of bone graft substitutes in the management of tibial plateau fractures. Injury 44(suppl 1):S86–S94. doi:10.1016/S0020-1383(13)70019-6

    Article  PubMed  Google Scholar 

  8. Zimmermann G, Moghaddam A (2011) Allograft bone matrix versus synthetic bone graft substitutes. Injury 42(suppl 2):S16–S21. doi:10.1016/j.injury.2011.06.199

    Article  PubMed  Google Scholar 

  9. Zwingenberger S, Nich C, Valladares RD, Yao Z, Stiehler M, Goodman SB (2012) Recommendations and considerations for the use of biologics in orthopedic surgery. BioDrugs 26(4):245–256. doi:10.2165/11631680-000000000-00000

    PubMed  CAS  Google Scholar 

Download references

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Orthopaedic and Traumatologic Clinic, Rizzoli Orthopaedic Institute, University of Bologna, Bologna, BO, Italy

    Eugenio Chiarello, Matteo Cadossi, Giuseppe Tedesco, Paola Capra, Carlotta Calamelli, Alba Shehu & Sandro Giannini

Authors
  1. Eugenio Chiarello
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Matteo Cadossi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Giuseppe Tedesco
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Paola Capra
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Carlotta Calamelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alba Shehu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sandro Giannini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eugenio Chiarello.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chiarello, E., Cadossi, M., Tedesco, G. et al. Autograft, allograft and bone substitutes in reconstructive orthopedic surgery. Aging Clin Exp Res 25 (Suppl 1), 101–103 (2013). https://doi.org/10.1007/s40520-013-0088-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40520-013-0088-8

Keywords

Search

Navigation