Plasma orexin-A level associated with physical activity in obese people

  • Yuan-yuan Hao
  • Hong-wang Yuan
  • Peng-hua Fang
  • Yu Zhang
  • Yue-xia Liao
  • Chen Shen
  • Dan Wang
  • Ting-ting Zhang
  • Ping BoEmail author
Original Article



To measure the amount of physical activity (PA) among obese adults, investigate the association between plasma orexin-A level and PA patterns, and explore the effect of orexin on the prevention and control of obesity.


Interviews were conducted in 218 participants (106 obese; 73 overweight; and 39 normal) who ranged in age between 18 and 70 years using a survey that included sociodemographic variables. The International Physical Activity Questionnaire (IPAQ-long version) was used to measure PA. A total of 178 participants agreed to submit blood sample collections, and plasma orexin-A content was measured by ELISA testing.


The average level of orexin-A was 85.34 ± 42.85 ng/L in the obese group, 97.38 ± 36.72 ng/L in the overweight group, and 106.56 ± 52.09 ng/L in the control group, which was significantly different (P = 0.03). The concentration of plasma orexin-A correlated with the total PA (P = 0.000), moderate PA (obese = 0.007; overweight: P = 0.000; control: P = 0.000), and walking PA (P = 0.000) in all three groups. Working and domestic PAs were significantly associated with the plasma orexin-A level (P < 0.0001).


The plasma orexin-A level was associated with PA in obese and overweight people, including many aspects of daily life, such as working, domestic work, and walking especially.


Orexin-A Physical activity Obesity 



We thank the Chinese medicine integrated with Western medicine Lab for supporting the experimental techniques. This study was supported by the Natural Science Foundation of China (Grant number: 81173392).

Compliance with ethical standards


National Natural Science Foundation of China (No. 81173392).

Conflict of interest

The authors declare that there is no conflict of interests regarding the publication of this article.

Ethical approval

All procedures performed in this study involving human participants were in accordance with the ethical standards of the committee of School of Medicine of Yangzhou University and with the 1964 Helsinki declaration and its later amendments.

Informed consent

Informed consent was obtained from the patient included in the case report.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Yuan-yuan Hao
    • 1
  • Hong-wang Yuan
    • 1
  • Peng-hua Fang
    • 1
  • Yu Zhang
    • 1
  • Yue-xia Liao
    • 1
  • Chen Shen
    • 2
  • Dan Wang
    • 3
  • Ting-ting Zhang
    • 1
  • Ping Bo
    • 1
    Email author
  1. 1.School of MedicineYangzhou UniversityYangzhouThe People’s Republic of China
  2. 2.Pediatric Cardiothoracic Surgical Department of Jiangsu Province HospitalNanjingThe People’s Republic of China
  3. 3.Colorectal Surgical Department of Jiangsu Province HospitalNanjingThe People’s Republic of China

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