Adiponectin gene variants and abdominal obesity in an Iranian population

  • Moloud Payab
  • Mahsa M. AmoliEmail author
  • Mostafa Qorbani
  • Shirin Hasani-RanjbarEmail author
Original Article



Waist-to-height ratio (WHtR) can be effective for the diagnosis of abdominal obesity and the risk of type 2 diabetes. The role of genetic factors in the development of obesity has been broadly recognized. Adiponectin’s level is inversely correlated with body fat percentage and is reduced in obesity and type 2 diabetes. The aim of this study is to investigate the association between WHtR and adiponectin gene polymorphisms in Iranian population.


This study was conducted on 610 subjects from two Iranian populations. Anthropometric characteristics were measured by routine methods. Blood samples were collected in tubes (3–5 mL) containing EDTA and were stored at 20 °C. After DNA extraction, genotyping was performed using PCR–RFLP technique.


There were statistically significant differences in genotype frequencies of −11391 G/A in centrally obese (WHtR >0.5) and noncentrally obese (WHtR ≤0.5) subjects (P value <0.044). In the former, the frequencies of GG and GA + AA genotypes were 89.4 and 10.6 %, respectively, while the frequencies of GG and GA + AA genotypes were 95.9 and 4.1 %, respectively, in noncentrally obese subjects.


The frequency of GG genotype was significantly increased in subjects with WHtR >0.5 compared to the other group. After adjustment for diabetes, abdominal obesity was significantly associated with the −11391 G/A polymorphism.


Obesity Adiponectin Diabetes Abdominal obesity Polymorphism Waist-to-height ratio Metabolic syndrome 



Waist-to-height ratio


Waist circumference


Body mass index



Implementation of this study was sponsored by Tehran University of Medical Sciences (Endocrinology and Metabolism Research Center).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical standard

The study has been approved by ethical committee of Tehran University of Medical Sciences.

Informed consent

Informed consents have been obtained from all patients participating in the study.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical Sciences, Shariati HospitalTehranIran
  2. 2.Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran
  3. 3.Department of Community MedicineAlborz University of Medical SciencesKarajIran
  4. 4.Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences InstituteTehran University of Medical SciencesTehranIran
  5. 5.Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences InstituteTehran University of Medical SciencesTehranIran

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