Stress inhibits PYY secretion in obese and normal weight women
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The impact of stress on circulating levels of appetite-regulating hormones remains largely unknown. The aim of this study was to analyze the effect of acute psychosocial stress on the gut hormone peptide YY (PYY) secretion in obese and normal weight women. Therefore, we compared pre- and post-prandial plasma PYY secretion of 42 obese and 43 normal weight women in a repeated measure randomized controlled laboratory experiment. PYY and cortisol concentrations were measured and ratings of stress and satiety were also recorded in response to a psychological stressor (Trier Social Stress Test, TSST). PYY samples were collected in the fasting state both before participating in the TSST and before a control session. Participants had a standardized meal after the TSST and control session, respectively. PYY was measured both 30 and 60 min after the TSST and control session, respectively. Stress inhibited PYY secretion as well as food intake in all women, but did not influence subjective satiety perception. The present data indicate that despite of lower PYY levels the subjects’ requirement to overeat was not increased. From an evolutionary perspective this finding is adaptive. After stress the organism is prepared for fight or flight reaction, whereas not primarily necessary functions are inhibited. Therefore, increased food intake during stress would be dysfunctional.
KeywordsStress PYY Obesity Eating behavior
Compliance with ethical standards
Conflict of interest
Authors have no potential conflict of interest.
The study was approved by the ethical committee of medicine in Rheinland‐ Pfalz, Germany (20.4.2012).
Informed consent was obtained from all individual participants included in the study.
- 6.Lawson EA, Eddy KT, Donoho D, Misra M, Miller KK, Meenaghan E, Lydecker J, Herzog D, Klibanski A (2011) Appetite-regulating hormones cortisol and peptide YY are associated with disordered eating psychopathology, independent of body mass index. Eur J Endocrinol 164(2):253–261. doi: 10.1530/EJE-10-0523 CrossRefPubMedPubMedCentralGoogle Scholar
- 7.Zwirska-Korczala K, Konturek SJ, Sodowski M, Wylezol M, Kuka D, Sowa P, Adamczyk-Sow M, Kukla M, Berdowska A, Rehfeld JF, Bielanski W, Brzozowsk T (2007) Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome. J Physiol Pharmacol 58(1):13–35PubMedGoogle Scholar
- 13.Challis BG, Coll AP, Yeo GSH, Pinnock SB, Dickson SL, Thresher RR, Dixon J, O’Rahilly S (2004) Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY3-36. Proc Natl Acad Sci USA 101(13):4695–4700. doi: 10.1073/pnas.0306931101 CrossRefPubMedPubMedCentralGoogle Scholar
- 15.Abbott CR, Small CJ, Sajedi A, Smith KL, Parkinson JRC, Broadhead LL, Ghatei MA, Bloom SR (2006) The importance of acclimatisation and habituation to experimental conditions when investigating the anorectic effects of gastrointestinal hormones in the rat. Int J Obes 30(2):288–292. doi: 10.1038/sj.ijo.0803137 CrossRefGoogle Scholar
- 17.Chandarana K, Drew ME, Emmanuel J, Karra E, Gelegen C, Chan P, Cron NJ, Batterham RL (2009) Subject standardization, acclimatization, and sample processing affect gut hormone levels and appetite in humans. Gastroenterology 136(7):2115–2126. doi: 10.1053/j.gastro.2009.02.047 CrossRefPubMedGoogle Scholar
- 19.Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH (2003) Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 28:916–931. doi: 10.1016/S0306-4530(97)00072-3 CrossRefPubMedGoogle Scholar
- 22.World Health Organization (2013) BMI classification 2013. World Health Organization. http://apps.who.int/bmi/index.jsp