Advances in Infection Control for Clostridioides (Formerly Clostridium) difficile Infection

  • Carlos E. Figueroa CastroEmail author
  • L. Silvia Munoz-Price
New Technologies and Advances in Infections Prevention (A Marra, Section Editor)
Part of the following topical collections:
  1. Topical Collection on New Technologies and Advances in Infection Prevention


Purpose of review

We reviewed seminal papers and recently published articles discussing multiple aspects of infection prevention applied to Clostridioides (formerly Clostridium) difficile infection (CDI).

Recent findings

We identified hot topics including the importance of understanding the gut microbiome in CDI and its implications from an infection prevention perspective, the increasing role of antibiotic stewardship including testing stewardship in preventing and mitigating CDI, and the increasing role of clinical decision support systems to improve early diagnosis and decrease inappropriate testing.


In addition to established infection prevention interventions, CDI control will be achieved by a combination of gut microbiome manipulation, personalized medicine based on host and agent genome analysis, and a combination of antimicrobials and testing stewardship by leveraging progressively sophisticated electronic decision systems. Automated environmental decontamination systems are not routinely recommended at this time.


Clostridium difficile Clostridioides difficile Infection prevention Antimicrobial stewardship Microbiome Clinical decision support system 


Compliance with Ethical Standards

Conflict of Interest

Dr. Munoz-Price had received grant funds from Cepheid.

Dr. Figueroa Castro declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References and Recommended Reading

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Carlos E. Figueroa Castro
    • 1
    Email author
  • L. Silvia Munoz-Price
    • 1
  1. 1.Department of Medicine, Division of Infectious DiseasesMedical College of WisconsinMilwaukeeUSA

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