Current Oral Health Reports

, Volume 6, Issue 1, pp 22–30 | Cite as

Is Human Papilloma Virus Infection Linked to Periodontitis? A Narrative Review

  • Ana P. OrtizEmail author
  • Jeslie M. Ramos-Cartagena
  • Sandra I. García-Camacho
  • Oelisoa M. Andriankaja
  • Cynthia M. Pérez
Systemic Diseases (N Buduneli, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Systemic Diseases


Purpose of Review

Research suggests that periodontal tissue might serve as a reservoir for oral human papillomavirus (HPV) infection, while another hypothesis is that chronic inflammation of the tissue might perpetuate an infection with oral HPV infection. In this narrative review, we summarize the evidence related to a potential association between oral HPV infection and periodontitis.

Recent Findings

Twelve articles were identified, and their key findings summarized. Studies vary in sample size, study population, study design, and methods for assessment of oral HPV and periodontitis. Although results are conflicting and still inconclusive, various studies have found an association between oral HPV infection and periodontitis, which is supported by biological plausibility.


Future longitudinal studies should further evaluate this association, using clinical definitions of oral HPV infection and periodontitis, and focusing on high-risk populations for oral HPV infection. Studying this association is important since periodontitis might help identify at-risk individuals for oral HPV infection and potentially HPV-related oropharyngeal cancers.


Periodontitis Gingivitis Oral human papillomavirus Oral cancer 



This work was supported by the National Institutes of Health [1R21DE024850-01A1, NIDCR] and [1R21DE027226-01A1, NIDCR].

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any new studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ana P. Ortiz
    • 1
    • 2
    Email author
  • Jeslie M. Ramos-Cartagena
    • 2
  • Sandra I. García-Camacho
    • 2
  • Oelisoa M. Andriankaja
    • 3
  • Cynthia M. Pérez
    • 1
  1. 1.Department of Biostatistics and Epidemiology, Graduate School of Public HealthUniversity of Puerto Rico Medical Sciences CampusSan JuanPuerto Rico
  2. 2.Cancer Control and Population Sciences DivisionUniversity of Puerto Rico Comprehensive Cancer CenterSan JuanPuerto Rico
  3. 3.Center for Clinical Research and Health Promotion, School of Dental Medicine, University of Puerto RicoMedical Sciences CampusSan JuanPuerto Rico

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