Current Oral Health Reports

, Volume 4, Issue 3, pp 215–227 | Cite as

Recent Advances in Adhesive Bonding: The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates

  • Eliseu A. MünchowEmail author
  • Marco C. Bottino
Dental Restorative Materials (M Özcan, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Dental Restorative Materials


Purpose of review

To present an overview on the main agents (i.e. biomolecules and nanocompounds) and/or strategies currently available to amplify or stabilize resin-dentin bonding.

Recent findings

According to studies retrieved for full-text reading (2014–2017), there are currently six major strategies available to overcome resin-dentin bond degradation: (1) use of collagen crosslinking agents, which may form stable covalent bonds with collagen fibrils, thus strengthening the hybrid layer; (2) use of antioxidants, which may allow further polymerization reactions over time; (3) use of protease inhibitors, which may inhibit or inactivate metalloproteinases; (4) modification of the bonding procedure, which may be performed by using the ethanol-wet bonding (EWB) technique or by applying an additional adhesive (hydrophobic) coating, thereby strengthening the hybrid layer; (5) laser treatment of the substrate prior to bonding, which may cause specific topographic changes in the surface of dental substrates, increasing bonding efficacy; and (6) reinforcement of the resin matrix with inorganic fillers and/or remineralizing agents, which may positively enhance physicomechanical properties of the hybrid layer.


With the present review, we contributed to the better understanding of adhesion concepts and mechanisms of resin-dentin bond degradation, showing the current prospects available to solve that problematic. In addition, adhesively-bonded restorations may be benefited by the use of some biomolecules, nanocompounds or alternative bonding strategies in order to minimize bond strength degradation.


Matrix metalloproteinase inhibitors Collagen Resins Crosslinking agents Dentin-bonding Dentin 



Marco C. Bottino acknowledges start-up funds from the Indiana University School of Dentistry and the National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR) [grant number DE023552]. The content of this review is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Compliance with Ethical Standards

Conflict of Interest

Eliseu A. Münchow and Marco C. Bottino declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as • Of importance •• Of major importance

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Dentistry, Health Science InstituteFederal University of Juiz de ForaGovernador ValadaresBrazil
  2. 2.Department of Biomedical and Applied Sciences, Division of Dental BiomaterialsIndiana University School of DentistryIndianapolisUSA

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