Recent Advances in Adhesive Bonding: The Role of Biomolecules, Nanocompounds, and Bonding Strategies in Enhancing Resin Bonding to Dental Substrates
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Purpose of review
To present an overview on the main agents (i.e. biomolecules and nanocompounds) and/or strategies currently available to amplify or stabilize resin-dentin bonding.
According to studies retrieved for full-text reading (2014–2017), there are currently six major strategies available to overcome resin-dentin bond degradation: (1) use of collagen crosslinking agents, which may form stable covalent bonds with collagen fibrils, thus strengthening the hybrid layer; (2) use of antioxidants, which may allow further polymerization reactions over time; (3) use of protease inhibitors, which may inhibit or inactivate metalloproteinases; (4) modification of the bonding procedure, which may be performed by using the ethanol-wet bonding (EWB) technique or by applying an additional adhesive (hydrophobic) coating, thereby strengthening the hybrid layer; (5) laser treatment of the substrate prior to bonding, which may cause specific topographic changes in the surface of dental substrates, increasing bonding efficacy; and (6) reinforcement of the resin matrix with inorganic fillers and/or remineralizing agents, which may positively enhance physicomechanical properties of the hybrid layer.
With the present review, we contributed to the better understanding of adhesion concepts and mechanisms of resin-dentin bond degradation, showing the current prospects available to solve that problematic. In addition, adhesively-bonded restorations may be benefited by the use of some biomolecules, nanocompounds or alternative bonding strategies in order to minimize bond strength degradation.
KeywordsMatrix metalloproteinase inhibitors Collagen Resins Crosslinking agents Dentin-bonding Dentin
Marco C. Bottino acknowledges start-up funds from the Indiana University School of Dentistry and the National Institutes of Health/National Institute of Dental and Craniofacial Research (NIH/NIDCR) [grant number DE023552]. The content of this review is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Compliance with Ethical Standards
Conflict of Interest
Eliseu A. Münchow and Marco C. Bottino declare that they have no conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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- 2.•• Pashley DH, Tay FR, Breschi L, Tjaderhane L, Carvalho RM, Carrilho M, et al. State of the art etch-and-rinse adhesives. Dent Mater. 2011;27:1–16. This article represents the state of the art of etch-and-rinse dental adhesives, explaining how bond strength degradation may occur under clinical conditions. CrossRefPubMedGoogle Scholar
- 3.•• Van Meerbeek B, Yoshihara K, Yoshida Y, Mine A, De Munck J, Van Landuyt KL. State of the art of self-etch adhesives. Dent Mater. 2011;27:17–28. This article represents the state of the art of self-etch dental adhesives, showing important chemical explanations concerning bond strength degradation of resin-dentin adhesion. CrossRefPubMedGoogle Scholar
- 4.•• De Munck J, Van Landuyt K, Peumans M, Poitevin A, Lambrechts P, Braem M, et al. A critical review of the durability of adhesion to tooth tissue: methods and results. J Dent Res. 2005;84:118–32. This article is a classical study that critically reviewed the literature with regard to the durability of resin to dentin/enamel bonds. CrossRefPubMedGoogle Scholar
- 22.Khamverdi Z, Rezaei-Soufi L, Rostamzadeh T. The effect of epigallocatechin gallate on the dentin bond durability of two self-etch adhesives. J Dent (Shiraz). 2015;16:68–74.Google Scholar
- 32.• Feitosa SA, Palasuk J, Kamocki K, Geraldeli S, Gregory RL, Platt JA, et al. Doxycycline-encapsulated nanotube-modified dentin adhesives. J Dent Res. 2014;93:1270–6. This article shows how nanotubes can be used as a delivery system for the increase/stabilization of resin-dentin bonds, which may present an innovation in modern adhesive dentistry. CrossRefPubMedPubMedCentralGoogle Scholar
- 36.• Bedran-Russo AK, Pashley DH, Agee K, Drummond JL, Miescke KJ. Changes in stiffness of demineralized dentin following application of collagen crosslinkers. J Biomed Mater Res B Appl Biomater. 2008;86:330–4. This article brings one of the first insights concerning dentin biomodification with collagen crosslinking agents. CrossRefPubMedGoogle Scholar
- 47.• Montagner AF, Sarkis-Onofre R, Pereira-Cenci T, Cenci MS. MMP Inhibitors on dentin stability: a systematic review and meta-analysis. J Dent Res. 2014;93:733–43. This article represents a systematic review of studies that used MMP inhibitors to produce resin-dentin bonding stability over time, which demonstrates that self-etching and etch-and-rinse adhesives are benefited by the use of chlorhexidine. CrossRefPubMedPubMedCentralGoogle Scholar
- 94.• Liu Y, Tjaderhane L, Breschi L, Mazzoni A, Li N, Mao J, et al. Limitations in bonding to dentin and experimental strategies to prevent bond degradation. J Dent Res. 2011;90:953–68. This article brings an overview regarding limitations in bonding to dentin and the possible strategies available to prevent bond degradation, which may include increasing conversion and esterase resistance of hydrophilic monomers, using MMP inhibitors or collagen crosslinkers, using the ethanol wet-bonding technique or biomimetic remineralization. CrossRefPubMedPubMedCentralGoogle Scholar