Abstract
Purpose of Review
Redox-related diseases are prevalent globally. Given the cost of allopathic medicines, “green preparations” are often relied on in economically developing countries. This review sought to identify medicinal plants of sub-Saharan Africa which have scientifically validated antioxidant properties, the compounds responsible for these properties, and to highlight the role of nanosizing of such plant materials in the medical future for the region.
Recent Findings
Eighteen plants (from 13 families) with reported antioxidant properties were identified. The Euphorbiaceae (3 plants) and Capparaceae (2 plants) were the most represented families. Most of the plants were reported to be used in folk medicine for the treatment of infections and inflammation, and water and methanol were the most widely used solvents for preparing the bioactive extracts. In vitro studies (13 cases) predominated. Forty-six different bioactive compounds were reported in the 18 plants identified. Catechin/epicatechin (13 plants), gallic acid (7 plants), caffeic acid, chlorogenic acid, and vitexin/isovitexin (5 plants each) were the most widely reported antioxidant phytochemicals. Given that synergism can occur to enhance the antioxidant activities of phytochemicals, nanosizing the plant leaves identified may open new vistas of opportunities in the development of redox active green pharmaceuticals.
Summary
Given the abundance of antioxidant phenolics in the plants of sub-Saharan Africa, and the challenges of solvent extraction techniques (with respect to upscaling), nanosizing presents an eco-friendly means of sustainably exploiting these plant resources for medicinal purposes. Therefore, it appears that “a small green red-ox carries a bright medical future for sub-Saharan Africa.”
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Acknowledgments
The authors acknowledge the support of their respective Universities: The Alex Ekwueme Federal University, Ndufu-Alike, Ebonyi State, Nigeria; the Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria; the Cranfield University, UK; the University of Saarland, Germany; and the University of Ottawa, Canada. CJ thanks the NutRedOx and Academics International networks for their support. CECCE thanks the DAAD for a 2018 research stays fellowship.
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Conception, CECCE and CJ; literature search and data mining, ICO and CA; structures, ICO; figures, CECCE; table, CA and CECCE; preparation of initial draft of manuscript, CA, IIE, and CECCE; correction of draft for intellectual content, CCU and CJ; manuscript revision after peer-review, CCU and CECCE. All authors read and approved the final version of the manuscript.
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Aloke, C., Ezeigbo, I.I., Ohanenye, I.C. et al. A Small Green Red-Ox Carries a Bright Medical Future for Sub-Saharan Africa. Curr Pharmacol Rep 5, 245–254 (2019). https://doi.org/10.1007/s40495-019-00182-9
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DOI: https://doi.org/10.1007/s40495-019-00182-9