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Current Pharmacology Reports

, Volume 3, Issue 6, pp 384–395 | Cite as

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

  • Yonghong Li
  • Victor Pham
  • Michelle Bui
  • Liankun Song
  • Chunli Wu
  • Arman Walia
  • Edward Uchio
  • Feng Smith-Liu
  • Xiaolin ZiEmail author
Cancer Chemoprevention (R Agarwal, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Cancer Chemoprevention

Abstract

Purpose of Review

Rhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to nonspecifically enhance the natural resistance of the body to both physical and behavior stresses for fighting fatigue and depression. We summarize the information with respect to the new pharmacological activities of Rhodiola rosea extracts and its underlying molecular mechanisms in this review article.

Recent Findings

In addition to its multiplex stress-protective activity, Rhodiola rosea extracts have recently demonstrated its anti-aging, anti-inflammation, immunostimulating, DNA repair, and anti-cancer effects in different model systems. Molecular mechanisms of Rhodiola rosea extracts’ action have been studied mainly along with one of its bioactive compounds, salidroside. Both Rhodiola rosea extracts and salidroside have contrast molecular mechanisms on cancer and normal physiological functions. For cancer, Rhodiola rosea extracts and salidroside inhibit the mTOR pathway and reduce angiogenesis through downregulation of the expression of HIF-1α/HIF-2α. For normal physiological functions, Rhodiola rosea extracts and salidroside activate the mTOR pathway, stimulate paracrine function, and promote neovascularization by inhibiting PHD3 and stabilizing HIF-1α proteins in skeletal muscles. In contrast to many natural compounds, salidroside is water-soluble and highly bioavailable via oral administration and concentrated in urine by kidney excretion.

Summary

Rhodiola rosea extracts and salidroside can impose cellular and systemic benefits similar to the effect of positive lifestyle interventions to normal physiological functions and for anti-cancer. The unique pharmacological properties of Rhodiola rosea extracts or salidroside deserve further investigation for cancer chemoprevention, in particular for human urinary bladder cancer.

Keywords

Chemoprevention Rhodiola Salidroside Hypoxia mTOR and DNA repair 

Notes

Acknowledgments

This work was supported in part by NIH award 1R01CA193967-01A1 and 1R21CA152804-01A1 (to X. Zi.). Victor Pham is currently supported by NSF graduate research fellowship program DGE-1321846.

Compliance with Ethical Standards

Conflict of Interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of UrologyUniversity of CaliforniaOrangeUSA
  2. 2.Department of Pharmaceutical SciencesUniversity of CaliforniaIrvineUSA
  3. 3.Department of EpidemiologyUniversity of CaliforniaIrvineUSA
  4. 4.Department of PharmacologyUniversity of CaliforniaIrvineUSA

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