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Disposition of Flavonoids for Personal Intake

  • Molecular Drug Disposition (M Hu, Section Editor)
  • Published:
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Abstract

Flavonoids represent a group of polyphenolic phytochemicals. Diverse biological activities of flavonoids are becoming increasingly popular in scientific and public research. Epidemiological human intervention studies showed association of flavonoids to several diseases, which include cancer, neurodegeneration, and cardiovascular diseases. Variation in pathways affecting absorption, distribution, metabolism, and excretion (ADME) of flavonoids possibly influences exposure at the circulatory system, thus modifying disease risk in individuals. This article focuses on current knowledge on factors affecting disposition of flavonoids and personal intake. These factors include nuclear receptors (NRs), gene transcriptional regulation of drug-metabolizing enzymes (DMEs), and efflux transporters (ETs). First, we summarize the current knowledge for main subclasses of flavonoids and their metabolism pathways. Important novel insights proved that regulatory mechanisms control enzyme activities and gene expressions of these DMEs and ETs by NRs. Typically, considerable evidence showed that NRs directly or indirectly regulate expressions of critical DMEs and drug transporters. Variation in metabolism pathways of flavonoids, polymorphic phase II enzymes, and ETs contributes to variability of flavonoid disposition. Covariation of enzymes, ETs, and NRs can explain individual variability of flavonoid disposition. Thus, identified gaps in these factors must be addressed to further understand flavonoid intake, which can serve as basis for more comprehensive evaluation of the effects of these dietary supplies on health.

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Acknowledgments

This work was supported by the grants of the National Natural Science Foundation of China (81120108025 and 81503466), Science and Technology Project of Guangzhou City (201509010004), and Guangdong Natural Science Foundation (2015AD030312012 and 2015B020233015).

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  1. Shuqiang Liu, Haihui Zheng, and Rongjin Sun equally contributed to this paper.

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  1. International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China

    Shuqiang Liu, Haihui Zheng, Rongjin Sun, Huangyu Jiang, Jiamei Chen, Jia Yu, Qisong Zhang, Qingwei Chen, Lijun Zhu, Ming Hu, Linlin Lu & Zhongqiu Liu

  2. State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, SAR, China

    Zhongqiu Liu

  3. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77030, USA

    Ming Hu

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Liu, S., Zheng, H., Sun, R. et al. Disposition of Flavonoids for Personal Intake . Curr Pharmacol Rep 3, 196–212 (2017). https://doi.org/10.1007/s40495-017-0095-0

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