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Syndromic Autism: Progressing Beyond Current Levels of Description

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Abstract

Genetic syndrome groups at high risk of autism comorbidity, like Down syndrome and fragile X syndrome, have been presented as useful models for understanding risk and protective factors involved in the emergence of autistic traits. Yet despite reaching clinical thresholds, these ‘syndromic’ forms of autism appear to differ in significant ways from the idiopathic or ‘non-syndromic’ autism profile. We explore alternative mechanistic explanations for these differences and propose a developmental interpretation of syndromic autism that takes into account the character of the genetic disorder. This interpretation anticipates syndrome-specific autism phenotypes, since the neurocognitive and behavioural expression of the autism is coloured by syndromically defined atypicalities. To uncover the true nature of comorbidities and of autism per se, we argue that it is key to extend definitions of autism to include the perceptual and neurocognitive characteristics of the disorder and then apply this multilevel conceptualisation to the study of syndromic autism profiles.

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References

  • Abrahams, B. S., & Geshwind, D. H. (2008). Advances in autism genetics: on the threshold of a new neurobiology. Nature Reviews Genetics, 5, 341–355. doi:10.1038/nrg2346.

    Article  Google Scholar 

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.

    Book  Google Scholar 

  • Amir, N., Weber, G., Beard, C., Bomyea, J., & Taylor, C. T. (2008). The effect of a single session attention modification program on response to a public speaking challenge in socially anxious individuals. Journal of Abnormal Psychology, 117, 860–868.

    Article  PubMed  PubMed Central  Google Scholar 

  • Baio, J. (2012). Prevalence of autism spectrum disorders: autism and developmental disabilities monitoring network, 14 sites, United States. Morbidity and Mortality Weekly Report, 61, 1–19.

    Google Scholar 

  • Baird, G., Simonoff, E., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., & Charman, T. (2010). Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP). Lancet, 368(9531), 210–215.

    Article  Google Scholar 

  • Beacher, F., Simmons, A., Daly, E., Prasher, V., Adams, C., Margallo-Lana, M. L., et al. (2005). Hippocampal myo-inositol and cognitive ability in adults with Down syndrome. An in vivo proton magnetic resonance spectroscopy study. Archives of General Psychiatry, 62(12), 1360–1365. doi:10.1001/archpsyc.62.12.1360.

    Article  PubMed  Google Scholar 

  • Behrmann, M., Avidan, G., Leonard, G. L., Kimchi, R., Luna, B., Humphreys, K., & Minshew, N. (2006). Configural processing in autism and its relationship to face processing. Neuropsychologia, 44(1), 110–129.

    Article  PubMed  Google Scholar 

  • Belichenko, P. V., Kleschevnikov, A. M., Becker, A., Wagner, G. E., Lysenko, L. V., Yu, Y. E., & Mobley, W. C. (2015). Down syndrome cognitive phenotypes modeled in mice trisomic for all HSA 21 homologues. PloS One, 10(7), e0134861. doi:10.1371/journal.pone.0134861.

    Article  PubMed  PubMed Central  Google Scholar 

  • Betancur, C. (2011). Etiological heterogeneity in autism spectrum disorders: more than 100 genetic and genomic disorders and still counting. Brain Research, 1380, 42–77.

    Article  PubMed  Google Scholar 

  • Brown, W. T., Jenkens, E. C., Friedman, E., Brooks, J., Wisniewski, K., Ragathu, S., & French, J. (1982). Autism is associated with the fragile X syndrome. Journal of Autism and Developmental Disorders, 12, 303–308.

    Article  PubMed  Google Scholar 

  • Brugha, T., Cooper, S. A., McManus, S., Purdon, S., Smith, J., Scott, F. J., et al. (2012). Estimating the prevalence of autism spectrum conditions in adults: extending the 2007 adult psychiatric morbidity survey. London: NHS, The Health and Social Care Information Centre.

    Google Scholar 

  • Caglayan, A. O. (2010). Genetic causes of syndromic and non-syndromic autism. Developmental Medicine & Child Neurology, 52, 130–138. doi:10.1111/j.1469-8749.2009.03523.x.

    Article  Google Scholar 

  • Capone, G., Grados, M., Kaufmann, W., Bernad-Ripoll, S., & Jewell, A. (2005). Down syndrome and co-morbid autism-spectrum disorder: characterization using the aberrant behavior checklist. American Journal of Medical Genetics, 134A, 373–380.

    Article  Google Scholar 

  • Carter, J. C., Capone, G. T., Gray, R. M., Cox, C. S., & Kaufmann, W. E. (2007). Autistic-spectrum disorders in Down syndrome: further delineation and distinction from other behavioral abnormalities. American Journal of Medical Genetics, 144B(1), 87–94.

    Article  PubMed  Google Scholar 

  • Channell, M. M., Phillips, B. A., Loveall, S. J., Conners, F. A., Bussanich, P. M., & Klinger, L. G. (2015). Patterns of autism spectrum symptomatology in individuals with Down syndrome without comorbid autism spectrum disorder. Journal of Neurodevelopmental Disorders, 7(1), 5. doi:10.1186/1866-1955-7-5.

    Article  PubMed  PubMed Central  Google Scholar 

  • Charman, T., Taylor, E., Drew, A., Cockerill, H., Brown, J., & Baird, G. (2005). Outcome at 7 years of children diagnosed with autism at age 2: predictive validity of assessments conducted at 2 and 3 years of age and pattern of symptom change over time. Journal of Child Psychology and Psychiatry, 46(5), 500–513.

    Article  PubMed  Google Scholar 

  • Chevallier, C., Kohls, G., Troiani, V., Brodkin, E. S., & Schultz, R. T. (2012). The social motivation theory of autism. Trends in Cognitive Sciences, 16(4), 231–239. doi:10.1016/j.tics.2012.02.007.

  • Cohen, I. L., Vietze, P. M., Sudhalter, V., Jenkins, E. C., & Brown, W. T. (1989). Parent-child dyadic gaze patterns in fragile X males and in non-fragile X males with autistic disorder. Journal of Child Psychology and Psychiatry, 30, 845–856. doi:10.1111/j.1469-7610.1989.tb00286.x.

    Article  PubMed  Google Scholar 

  • Cornish, K., Turk, J., & Levitas, A. (2007). Fragile X syndrome and autism: common developmental pathways? Current Pediatric Reviews, 3, 61–68.

    Article  Google Scholar 

  • Cornish, K., Cole, V., Longhi, E., Karmiloff-Smith, A., & Scerif, G. (2012). Does attention constrain developmental trajectories in fragile X syndrome? A 3-year prospective longitudinal study. American Journal on Intellectual and Developmental Disabilities, 117(2), 103–120. doi:10.1352/1944-7558-117.2.103.

    Article  PubMed  Google Scholar 

  • Dawson, G., Rogers, S., Munson, J., Smith, M., Winder, J., Greenson, J., et al. (2010). Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model. Pediatrics, 125(1), e17–e23. doi:10.1542/peds.2009-0958.

    Article  PubMed  Google Scholar 

  • Dawson, G., Jones, E. J., Merkle, K., Venema, K., Lowy, R., Faja, S., et al. (2012). Early behavioral intervention is associated with normalized brain activity in young children with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 51(11), 1150–1159. doi:10.1016/j.jaac.2012.08.018.

    Article  PubMed  PubMed Central  Google Scholar 

  • DiGuiseppi, C., Hepburn, S., Davis, J. M., Fidler, D. J., Hartway, S., Lee, N. R., et al. (2010). Screening for autism spectrum disorders in children with Down syndrome population prevalence and screening test characteristics. Journal of Developmental and Behavioral Pediatrics, 31(3), 181–191. doi:10.1097/DBP.0b013e3181d5aa6d.

    Article  PubMed  PubMed Central  Google Scholar 

  • Estes, A., Munson, J., Rogers, S. J., Greenson, J., Winter, J., & Dawson, G. (2015). Long-term outcomes of early intervention in 6-year-old children with autism spectrum disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 54(7), 580–587.

    Article  Google Scholar 

  • Frazier, T. W., Klingemier, E. W., Beukemann, M., Speer, L., Markowitz, L., Parikh, S., et al. (2016). Development of an objective autism risk index using remote eye tracking. Journal of the American Academy of Child & Adolescent Psychiatry, 55(4), 301–309.

    Article  Google Scholar 

  • Galdzicki, Z., & Siarey, R. J. (2003). Understanding mental retardation in Down’s syndrome using trisomy 16 mouse models. Genes, Brain and Behavior, 2, 167–178. doi:10.1034/j.1601-183X.2003.00024.x.

    Article  Google Scholar 

  • Gauthier, I., Klaiman, C., & Schultz, R. T. (2009). Face composite effects reveal abnormal face processing in autism spectrum disorders. Vision Research, 49(4), 470–478.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hagerman, R. J., & Harris, S. W. (2008). Autism profiles of males with fragile X syndrome. American Journal of Mental Retardation: AJMR, 113(6), 427–438.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hall, S. S., Lightbody, A. A., Hirt, M., Rezvani, A., & Reiss, A. L. (2010). Autism in fragile X syndrome: a category mistake? Journal of the American Academy of Child and Adolescent Psychiatry, 54, 921–933.

    Article  Google Scholar 

  • Hatton, D. D., Wheeler, A. C., Skinner, M. L., Bailey, D. B., Sullivan, K. M., Roberts, et al. (2003). Adaptive behavior in children with fragile X syndrome. American Journal of Mental Retardation, 108(6), 373–390.

    Article  PubMed  Google Scholar 

  • Hatton, D. D., Sideris, J., Skinner, M., Mankowski, J., Bailey Jr., D. B., Roberts, J., & Mirrett, P. (2006). Autistic behavior in children with fragile X syndrome: prevalence, stability, and the impact of FMRP. American Journal of Medical Genetics, 140A(17), 1804–1813.

    Article  PubMed  Google Scholar 

  • Hazen, R. A., Vasy, M. W., & Schmidt, N. B. (2009). Attention retraining: a randomized clinical trial for pathological worry. Journal of Psychiatric Research, 43, 627–633.

    Article  PubMed  Google Scholar 

  • Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002). Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proceedings of the National Academy of Sciences of the United States of America, 99(11), 7746–7750. doi:10.1073/pnas.122205699.

    Article  PubMed  PubMed Central  Google Scholar 

  • Irwin, S. A., Patel, B., Idupulapati, M., Harris, J. B., Crisostomo, R. A., Larsen, B. P., et al. (2001). Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination. American Journal of Medical Genetics, 98(2), 161–167.

    Article  PubMed  Google Scholar 

  • Jin, P., & Warren, S. T. (2000). Understanding the molecular basis of fragile X syndrome. Human Molecular Genetics, 9(6), 901–908.

    Article  PubMed  Google Scholar 

  • Johnson, M. H. (2017). Autism as an adaptive common variant pathway for human brain development. Developmental Cognitive Neuroscience. doi:10.1016/j.dcn.2017.02.004.

  • Karmiloff-Smith, A. (2009). Nativism versus neuroconstructivism: rethinking the study of developmental disorders. American Psychological Association, 45(1), 56–63. doi:10.1073/pnas.1121087109.

    Google Scholar 

  • Karmiloff-Smith, A., Thomas, M., Annaz, D., Humphreys, K., Ewing, S., Brace, N., et al. (2004). Exploring the Williams syndrome face processing debate: the importance of building developmental trajectories. Journal of Child Psychology and Psychiatry, 45, 1258–1274.

    Article  PubMed  Google Scholar 

  • Karmiloff-Smith, A., Aschersleben, G., De Schonen, S., Elsabbagh, M., Hohenberger, A., & Serres, J. (2010). Constraints on the timing of infant cognitive change: Domain-specific or domain-general? International Journal of Developmental Science, 4(1), 31–45.

  • Lee, M., Martin, G. E., Berry-Kravis, E., & Losh, M. (2016). A developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome. Journal of Neurodevelopmental Disorders, 8, 47. doi:10.1186/s11689-016-9179-0.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lewis, P., Abbeduto, L., Murphy, M., Richmond, E., Giles, N., Bruno, L., & Schroeder, S. (2006). Cognitive, language and social-cognitive skills of individuals with fragile X syndrome with and without autism. Journal of Intellectual Disability Research, 50, 532–545. doi:10.1111/j.1365-2788.2006.00803.x.

    Article  PubMed  Google Scholar 

  • Loesch, D. Z., Bui, Q. M., Dissanayake, C., Clifford, S., Gould, E., Bulhak-Paterson, D., et al. (2007). Molecular and cognitive predictors of the continuum of autistic behaviours in fragile X. Neuroscience and Biobehavioural Reviews, 31(3), 315–326.

    Article  Google Scholar 

  • Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview–revised: a revised version of the diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685. doi:10.1007/BF02172145.

    Article  PubMed  Google Scholar 

  • Lord, C., Risi, S., Lambrecht, L., Cook Jr., E. H., Leventhal, B. L., Di Lavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223. doi:10.1023/A:1005592401947.

    Article  PubMed  Google Scholar 

  • Lowenthal, R., Paula, C. S., Schwartzman, J. S., Brunoni, D., & Mercadante, M. T. (2007). Prevalence of pervasive developmental disorders in Down’s syndrome. Journal of Autism and Developmental Disorders, 37, 1394–1395.

    Article  PubMed  Google Scholar 

  • Mathews, A., & MacLeod, C. (2002). Induced processing biases have causal effects on anxiety. Cognition and Emotion, 16, 331–354.

    Article  Google Scholar 

  • McDuffie, A., Thurman, A. J., Hagerman, R. J., & Abbeduto, L. (2015). Symptoms of autism in males with fragile X syndrome: a comparison to nonsyndromic ASD using current ADI-R scores. Journal of Autism and Developmental Disorder, 45(7), 1925–1937.

    Article  Google Scholar 

  • McPartland, J., Dawson, G., Webb, S. J., Panagiotides, H., & Carver, L. J. (2004). Event-related brain potentials reveal anomalies in temporal processing of faces in autism spectrum disorder. Journal of Child Psychology and Psychiatry, 45(7), 1235–1245.

    Article  PubMed  Google Scholar 

  • Molloy, C. A., Keddache, M., & Martin, L. J. (2005). Evidence for linkage on 21q and 7q in a subset of autism characterized by developmental regression. Molecular Psychiatry, 10, 741–746. doi:10.1038/sj.mp.4001691.

    Article  PubMed  Google Scholar 

  • Molloy, C. A., Murray, D. S., Kinsman, A., Castillo, H., Mitchell, T., Hickey, F. J., & Patterson, B. (2009). Differences in the clinical presentation of trisomy 21 with and without autism. Journal of Intellectual Disability Research, 53(2), 43–151.

    Article  Google Scholar 

  • Moss, J., & Howlin, P. (2009). Autism spectrum disorders in genetic syndromes: implications for diagnosis, intervention and understanding the wider ASD population. Journal of Intellectual Disability Research, 53, 852–872.

    Article  PubMed  Google Scholar 

  • Moss, J., Magiati, I., Charman, T., & Howlin, P. (2008). Stability of the autism diagnostic interview-revised from pre-school to elementary school age in children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 38(6), 1081–1091.

    Article  PubMed  Google Scholar 

  • Moss, J., Richards, C., Nelson, L., & Oliver, C. (2013). Prevalence and behavioural characteristics of autism spectrum disorder in Down syndrome. Autism: International Journal of Research and Practice, 17(4), 390–404. doi:10.1177/1362361312442790.

    Article  Google Scholar 

  • Philofsky, A., Hepburn, S. L., Hayes, A., Hagerman, R., & Rogers, S. J. (2004). Linguistic and cognitive functioning and autism symptoms in young children with fragile X syndrome. American Journal on Mental Retardation, 109, 208–218.

    Article  PubMed  Google Scholar 

  • Pierce, K., Marinero, S., Hazin, R., McKenna, B., Barnes, C. C., & Malige, A. (2016). Eye tracking reveals abnormal visual preference for geometric images as an early biomarker of an autism spectrum disorder subtype associated with increased symptom severity. Biological Psychiatry, 79(8), 657–666. doi:10.1016/j.biopsych.2015.03.032.

    Article  PubMed  Google Scholar 

  • Reeves, R. H., Irving, N. G., Moran, T. H., Wohn, A., Kitt, C., Sisodia, S. S., et al. (1995). A mouse model for Down syndrome exhibits learning and behaviour deficits. Nature Genetics, 11, 177–184. doi:10.1038/ng1095-177.

    Article  PubMed  Google Scholar 

  • Reymond, A., Marigo, V., Yaylaoglu, M. B., Leoni, A., Ucla, C., Scamuffa, N., et al. (2002). Human chromosome 21 gene expression atlas in the mouse. Nature, 420, 582–586. doi:10.1038/nature01178.

    Article  PubMed  Google Scholar 

  • Roberts, J. E., Weisenfeld, L. A., Hatton, D. D., Heath, M., & Kaufmann, W. E. (2007). Social approach and autistic behavior in children with fragile X syndrome. Journal of Autism and Developmental Disorders, 37, 1748–1760. doi:10.1007/s10803-006-0305-9.

    Article  PubMed  Google Scholar 

  • Robinson, E. B., Neale, B. M., & Hyman, S. E. (2015). Genetic research in autism spectrum disorders. Current Opinion in Pediatrics, 27(6), 685–691. doi:10.1097/MOP.0000000000000278.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rosner, B. A., Hodapp, R. M., Fidler, D. J., Sagun, J. N., & Dykens, E. M. (2004). Social competence in persons with Prader-Willi, Williams, and Down’s syndrome. Journal of Applied Research in Intellectual Disabilities, 17, 209–217.

    Article  Google Scholar 

  • Santoro, M. R., Bray, S. M., & Warren, S. T. (2012). Molecular mechanisms of fragile X syndrome: a twenty-year perspective. Annual Review of Pathology: Mechanisms of Disease, 7, 219–245.

    Article  Google Scholar 

  • Scherf, K. S., Elbich, D., Minshew, N., & Behrmann, M. (2015). Individual differences in symptom severity and behavior predict neural activation during face processing in adolescents with autism. NeuroImage: Clinical, 7, 53–67. doi:10.1016/j.nicl.2014.11.003.

  • Schmidt, N. B., Richey, J. A., Buckner, J. D., & Timpano, K. R. (2009). Attention training for generalized social anxiety disorder. Journal of Abnormal Psychology, 118, 5–14.

    Article  PubMed  Google Scholar 

  • Skuse, D. H. (2007). Rethinking the nature of genetic vulnerability to autistic spectrum disorders. Trends in Genetics, 23(8), 387–395.

    Article  PubMed  Google Scholar 

  • Soukup-Ascençao, T., D’Souza, D., D’Souza, H., & Karmiloff-Smith, A. (2016). Parent-child interaction as a dynamic contributor to learning and cognitive development in typical and atypical development. Journal for the Study of Education and Development, 39(4), 694–726.

    Google Scholar 

  • Thomas, M. S., Annaz, D., Ansari, D., Scerif, G., Jarrold, C., & Karmiloff-Smith, A. (2009). Using developmental trajectories to understand developmental disorders. Journal of Speech, Language, and Hearing Research, 52(2), 336–358. doi:10.1044/1092-4388(2009/07-0144).

    Article  PubMed  Google Scholar 

  • Thurman, A. J., McDuffie, A., Hagerman, R., & Abbeduto, L. (2014). Psychiatric symptoms in boys with fragile X syndrome: a comparison with nonsyndromic autism spectrum disorder. Research in Developmental Disabilities, 35(5), 1072–1086.

    Article  PubMed  PubMed Central  Google Scholar 

  • Turk, J., & Cornish, K. (1998). Face recognition and emotion perception in boys with fragile-X syndrome. Journal of Intellectual Disability Research, 6, 490–499.

    Article  Google Scholar 

  • Tye, C., Mercure, E., Ashwood, K. L., Azadi, B., Asherson, P., Johnson, M. H., et al. (2013). Neurophysiological responses to faces and gaze direction differentiate children with ASD, ADHD and ASD + ADHD. Developmental Cognitive Neuroscience, 5, 71–85. doi:10.1016/j.dcn.2013.01.001.

    Article  PubMed  Google Scholar 

  • Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y., Kuhl, D. P. A., Pizzuti, A., et al. (1991). Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell, 65(5), 905–914.

    Article  PubMed  Google Scholar 

  • Warner, G., Moss, J., Smith, P., & Howlin, P. (2014). Autism characteristics and behavioural disturbances in ~ 500 children with Down’s syndrome in England and Wales. Autism Research, 7(4), 433–441. doi:10.1002/aur.1371.

    Article  PubMed  Google Scholar 

  • Weick, J. P., Held, D. L., Bonadurer III, G. F., Doers, M. E., Liu, Y., Maguire, C., et al. (2013). Deficits in human trisomy 21 iPSCs and neurons. Proceedings of the National Academy of Sciences of the United States of America, 110(24), 9962–9967.

    Article  PubMed  PubMed Central  Google Scholar 

  • Weiler, I. J., & Greenough, W. T. (1999). Synaptic synthesis of the fragile X protein: possible involvement in synapse maturation and elimination. American Journal of Medical Genetics, 83, 248–252. doi:10.1002/(SICI)1096-8628(19990402)83:4<248::AID-AJMG3>3.0.CO;2-1.

    Article  PubMed  Google Scholar 

  • Weiler, I. J., Spangler, C. C., Klintsova, A. Y., Grossman, A. W., Kim, S. H., Bertaina-Anglade, V., et al. (2004). Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses. Proceedings of the National Academy of Sciences of the United States of America, 101(50), 17504–17509.

    Article  PubMed  PubMed Central  Google Scholar 

  • Weitzdoerfer, R., Dierssen, M., Fountoulakis, M., & Lubec, G. (2001). Fetal life in Down syndrome starts with normal neuronal density but impaired dendritic spines and synaptosomal structure. Journal of Neural Transmission, 61, 59–70.

    Google Scholar 

  • World Health Organization, WHO. (1994). International classification of diseases (10th ed.). Geneva: Author.

    Google Scholar 

  • Xavier, J., Bursztejn, C., Stiskin, M., Canitano, R., & Cohen, D. (2015). Autism spectrum disorders: an historical synthesis and a multidimensional assessment toward a tailored therapeutic program. Research in Autism Spectrum Disorders, 18, 21–33.

    Article  Google Scholar 

  • Yu, T., Liu, C., Belichenko, P., Clapcote, S. J., Li, S., Pao, A., et al. (2010). Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Research, 1366, 162–171.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This research was supported by Wellcome Trust Strategic Grant No. 098330/Z/12/Z, Economic and Social Research Council (ESRC) Grant RES-062-23-2721 (to Michael Thomas) and an ESRC studentship awarded to Jennifer Glennon.

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Correspondence to Jennifer M. Glennon.

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Jennifer M. Glennon, Department of Psychological Sciences, Birkbeck, University of London.

This research was supported by the Economic and Social Research Council (ESRC), Bloomsbury Doctoral Training Centre for the Social Sciences, University of London, WC1E 7HX.

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Glennon, J.M., Karmiloff-Smith, A. & Thomas, M.S.C. Syndromic Autism: Progressing Beyond Current Levels of Description. Rev J Autism Dev Disord 4, 321–327 (2017). https://doi.org/10.1007/s40489-017-0116-2

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