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Table 3 Relative bioavailability by bioequivalence of AAFP 500 mg in fed versus fasted conditions

From: The Effect of Food on the Absorption of Abiraterone Acetate from a Fine Particle Dosage Form: A Randomized Crossover Trial in Healthy Volunteers

Pharmacokinetic parameters Estimates AAFP 500 mg fed vs. fasted conditions
AUC0–∞ (ng · h/mL) GMR (%) 442.4
90% CI 366.5–534.0*
AUC0–t (ng · h/mL) GMR (%) 458.6
90% CI 379.0–554.9*
C max (ng/mL) GMR (%) 649.5
90% CI 471.6–894.5*
  1. AAFP abiraterone acetate fine particle, AUC 0–∞ area under the plasma concentration–time curve from time 0 extrapolated to infinite time, AUC 0–t area under the plasma concentration–time curve from time 0 to the time of the last quantifiable concentration, CI confidence interval, C max maximum concentration, GMR geometric mean ratio
  2. *90% CI corresponding to the GMR was above the recommended 80–125% limit of bioequivalence