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Engineering synthetic optogenetic networks for biomedical applications

  • Review
  • Published: 15 May 2017
  • Volume 5, pages 111–123, (2017)
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Quantitative Biology
Engineering synthetic optogenetic networks for biomedical applications
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  • Meiyan Wang1,
  • Yuanhuan Yu1,
  • Jiawei Shao1,
  • Boon Chin Heng2 &
  • …
  • Haifeng Ye1 

  • 777 Accesses

  • 1 Citation

  • Explore all metrics

Abstract

Background

Recently, optogenetics based on genetically encoded photosensitive proteins has emerged as an innovative technology platform to revolutionize manipulation of cellular behavior through light stimulation. It has enabled user defined control of various cellular behaviors with spatiotemporal precision and minimal invasiveness, creating unprecedented opportunities for biomedical applications.

Results

This article reviews current advances in optogenetic networks designed for the treatment of human diseases. We highlight the advantages of these optogenetic networks, as well as emerging questions and future perspectives.

Conclusions

Various optogenetic systems have been engineered to control biological processes at all levels using light and applied for numerous diseases, such as metabolic disorders, cancer, and immune diseases. Continued development of optogenetic modules will be necessary to precisely control of gene expression magnitude towards clinical medical practice in the context of real-world problems.

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Acknowledgements

This work was financially supported by the National Key Research and Development Program of China, Stem Cell and Translational Research (No. 2016YFA0100300), by the National Natural Science Foundation of China (Nos. 31522017, 31470834 and 31670869), by the Science and Technology Commission of Shanghai Municipality (Nos. 15QA1401500 and 14JC1401700), and by the Thousand Youth Talents Plan of China to H.Y.

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  1. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China

    Meiyan Wang, Yuanhuan Yu, Jiawei Shao & Haifeng Ye

  2. Department of Endodontology, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, 999077, China

    Boon Chin Heng

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Correspondence to Haifeng Ye.

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Wang, M., Yu, Y., Shao, J. et al. Engineering synthetic optogenetic networks for biomedical applications. Quant Biol 5, 111–123 (2017). https://doi.org/10.1007/s40484-017-0105-6

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  • Received: 07 December 2016

  • Revised: 24 January 2017

  • Accepted: 25 January 2017

  • Published: 15 May 2017

  • Issue Date: June 2017

  • DOI: https://doi.org/10.1007/s40484-017-0105-6

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Keywords

  • synthetic biology
  • mammalian designer cells
  • optogenetics
  • synthetic gene circuits
  • gene- and cell-based therapy
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