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Pseudopapillary solid tumour of the pancreas in paediatric age: description of a case report and review of the literature

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Abstract

Pseudopapillary solid tumour of the pancreas is a rare neoplasm that mainly affects young women in the second and third decade of life and less frequently children; originates from the exocrine component of the pancreas; and is characterized by slow growth, low potential for malignancy, and excellent prognosis following complete surgical resection. The tumour often presents as an asymptomatic abdominal mass that is accidentally detected during radiological investigations performed for other reasons. In this article, we report the clinical case of a 10-year-old girl who came to our observation for pain in the left hypochondrium, which had arisen for a week following a trauma; the imaging methods revealed a voluminous expansive pancreatic formation in the abdomen; on histological examination, the mass was a solid pseudopapillary tumour. Furthermore, we present a review of the literature aimed at highlighting the salient features of this neoplasm in paediatric age.

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References

  1. Frantz VK (1959) Tumours of the pancreas. In: Frantz VK (ed) Atlas of tumour pathology. Section VII. Fascicles 27 and 28. Armed Forces Institute of Pathology, Washington, DC, pp 32–33. https://doi.org/10.1002/bjs.18004720344

  2. Ozcan A, Arslanoglu C, Unal E, Patiroglu T, Ozdemir MA, Deniz K, Ozcan SS, Karakukcu M (2018) Evaluation of childhood solid pseudopapillary tumours of the pancreas. North Clin Istanb 5(3):207–210. https://doi.org/10.14744/nci.2017.27443

  3. Crucitti A, Grossi U, Giustacchini P, Tomaiuolo PM, Bellantone R (2010) Solid pseudopapillary tumour of the pancreas in children: report of a case and review of the literature. Updates Surg 62(1):69–72. https://doi.org/10.1007/s13304-010-0006-y

    Article  PubMed  Google Scholar 

  4. Berrada G, Belaaroussi S, Chbani K, Salam S, Laoudiyi D, Ouzidane L, Kebir AE, Guebessi NB, Benayad S, Mernissi F, Karkouri M, Anis S, Zemmouri MA (2020) Solid pseudopapillary tumour of the pancreas: a rare entity in children. Pan Afr Med J 35:137. https://doi.org/10.11604/pamj.2020.35.137.22404

  5. Buerke B, Domagk D, Heindel W, Wessling J (2012) Diagnostic and radiological management of cystic pancreatic lesions: important features for radiologists. Clin Radiol 67(8):727–737. https://doi.org/10.1016/j.crad.2012.02.008

    Article  CAS  PubMed  Google Scholar 

  6. Hager T, Kônigsrainer A, Gassner I, Klein-FrankeA SC, Hager J (2010) Solid pseudopapillary tumour of the páncreas in a 12-year-old girl—7 years follow-up and histopathological reevaluation: case report and subject review. Eur Surg 42(2):96–102. https://doi.org/10.1007/s10353-010-0525-2

    Article  Google Scholar 

  7. Chung EM, Travis MD, Conran RM (2006) Pancreatic tumours in children: radiologic-pathologic correlation. Radiographics 26(4):1211–1238. https://doi.org/10.1148/rg.264065012

    Article  PubMed  Google Scholar 

  8. Papavramidis T, Papavramidis S (2005) Solid pseudopapillary tumours of the pancreas: review of 718 patients reported in English literature. J Am Coll Surg 200(6):965–972. https://doi.org/10.1016/j.jamcollsurg.2005.02.011

    Article  PubMed  Google Scholar 

  9. Bender AM, Thompson ED, Hackam DJ, Cameron JL, Rhee DS (2018) Solid pseudopapillary neoplasm of the pancreas in a young paediatric patient: a case report and systematic review of the literature. Pancreas 47(10):1364–1368. https://doi.org/10.1097/MPA.0000000000001183

    Article  PubMed  Google Scholar 

  10. Yang Z, Gong Y, Ji M, Yang B, Qiao Z (2020) Differential diagnosis of pancreatoblastoma (PB) and solid pseudopapillary neoplasms (SPNs) in children by CT and MR imaging. Eur Radiol. https://doi.org/10.1007/s00330-020-07309-3

    Article  PubMed  PubMed Central  Google Scholar 

  11. Hwang J, Kim DY, Kim SC, Namgoong JM, Hong SM (2014) Solid-pseudopapillary neoplasm of the pancreas in children: can we predict malignancy? J Pediatr Surg 49(12):1730–1733. https://doi.org/10.1016/j.jpedsurg.2014.09.011

    Article  PubMed  Google Scholar 

  12. Lee SE, Jang JY, Hwang DW, Park KW, Kim SW (2008) Clinical features and outcome of solid pseudopapillary neoplasm: differences between adults and children. Arch Surg 143(12):1218–1221. https://doi.org/10.1001/archsurg.143.12.1218

    Article  PubMed  Google Scholar 

  13. Park JY, Kim SG, Park J (2014) Solid pseudopapillary tumour of the pancreas in children: 15-year experience at a single institution with assays using an immunohistochemical panel. Ann Surg Treat Res 86(3):130–135. https://doi.org/10.4174/astr.2014.86.3.130

    Article  PubMed  PubMed Central  Google Scholar 

  14. Minh Xuan N, Khanh Tuong TT, Quang Huy H (2020) A rare case of large solid pseudopapillary tumour in a child. Am J Case Rep. 21:e923990. https://doi.org/10.12659/AJCR.923990

  15. Brillantino C, Rossi E, Baldari D, Minelli R, Bignardi E, Paviglianiti G, Restivo G, Cangemi MA, Zeccolini R, Zeccolini M (2020) Duodenal hematoma in paediatric age: a rare case report. J Ultrasound. https://doi.org/10.1007/s40477-020-00545-9

    Article  PubMed  Google Scholar 

  16. Brillantino C, Rossi E, Bifano D, Minelli R, Tamasi S, Mamone R, Bignardi E, Zeccolini R, Zeccolini M, Vallone G (2020) An unusual onset of paediatric acute lymphoblastic leukemia. J Ultrasound. https://doi.org/10.1007/s40477-020-00461-y

  17. Di Serafino M, Vitale V, Severino R, Barbuto L, Vezzali N, Ferro F, Rossi E, Caprio MG, Raia V, Vallone G (2019) Paediatric ultrasonography of the pancreas: normal and abnormal findings. J Ultrasound 22(3):261–272. https://doi.org/10.1007/s40477-018-0348-8

    Article  PubMed  Google Scholar 

  18. Farina R, Foti PV, Iannace FA, Conti A, Pennisi I, Calcagno MC, Basile A (2020) True congenital multicystic disease of the pancreas in the infant: a very rare case. J Ultrasound. https://doi.org/10.1007/s40477-020-00472-9

    Article  PubMed  Google Scholar 

  19. Wang H, Li F, Liu J, Zhang S (2014) Ultrasound-guided core needle biopsy in diagnosis of abdominal and pelvic neoplasm in paediatric patients. Pediatr Surg Int 30(1):31–37. https://doi.org/10.1007/s00383-013-3427-0

    Article  PubMed  Google Scholar 

  20. Cantisani V, Mortele KJ, Levy A, Glickman JN, Ricci P, Passariello R, Ros PR, Silverman SG (2003) MR imaging features of solid pseudopapillary tumour of the pancreas in adult and paediatric patients. AJR Am J Roentgenol 181(2):395–401. https://doi.org/10.2214/ajr.181.2.1810395

    Article  PubMed  Google Scholar 

  21. Rodrigues-Duarte H, Torrão H, Coelho P, Noruegas M, Sanches M (2013) Solid pseudopapillary tumour of the pancreas in a child: imaging findings with diffusion-weighted MR imaging. JOP 14(2):195–198. https://doi.org/10.6092/1590-8577/1185

    Article  PubMed  Google Scholar 

  22. Guerrache Y, Soyer P, Dohan A, Faraoun SA, Laurent V, Tasu JP, Aubé C, Cazejust J, Boudiaf M, Hoeffel C (2014) Solid-pseudopapillary tumour of the pancreas: MR imaging findings in 21 patient. Clin Imaging 38(4):475–482. https://doi.org/10.1016/j.clinimag.2014.01.015

    Article  PubMed  Google Scholar 

  23. Lee JH, Yu JS, Kim H, Kim JK, Kim TH, Kim KW, Park MS, Kim JH, Kim YB, Park C (2008) Solid pseudopapillary carcinoma of the pancreas: differentiation from benign solid pseudopapillary tumour using CT and MRI. Clin Radiol 63(9):1006–1014. https://doi.org/10.1016/j.crad.2008.04.007

    Article  CAS  PubMed  Google Scholar 

  24. Shet NS, Cole BL, Iyer RS (2014) Imaging of paediatric pancreatic neoplasms with radiologic histopathologic correlation. AJR Am J Roentgenol 202(6):1337–1348. https://doi.org/10.2214/AJR.13.11513

    Article  PubMed  Google Scholar 

  25. Hu S, Lin X, Song Q, Chen K (2012) Solid pseudopapillary tumour of the pancreas in children: clinical and computed tomography manifestation. Radiol Med 117(7):1242–1249. https://doi.org/10.1007/s11547-012-0854-2

    Article  CAS  PubMed  Google Scholar 

  26. Yu PF, Hu ZH, Wang XB, Guo JM, Cheng XD, Zhang YL, Xu Q (2010) Solid pseudopapillary tumour of the pancreas: a review of 553 cases in Chinese literature. World J Gastroenterol 16(10):1209–1214. https://doi.org/10.3748/wjg.v16.i10.1209

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Rocco Minelli.

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Brillantino, C., Rossi, E., Pirisi, P. et al. Pseudopapillary solid tumour of the pancreas in paediatric age: description of a case report and review of the literature. J Ultrasound 25, 251–257 (2022). https://doi.org/10.1007/s40477-021-00587-7

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