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Carotid–femoral pulse wave velocity is significantly increased in newly diagnosed hypertensive patients with primary hyperparathyroidism and significantly related with serum calcium level

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Abstract

Background

Primary hyperparathyroidism (PHP) is a rare cause of secondary hypertension (HT), but in patients with PHP, HT is very common and 20–80% of patients have HT. The aim of this study was to evaluate the change in carotid–femoral pulse wave velocity (CF-PWV) in hypertensive patients with PHP, and was to determine the clinical, laboratory, and echocardiographic parameters associated with CF-PWV.

Methods

The study included 83 newly diagnosed hypertensive patients with PHP and 83 patients with newly diagnosed essential HT without PHP. All patients underwent echocardiography and CF-PWV measurements.

Results

In patients with PHP, blood urea nitrogen, hs-CRP, uric acid, serum and urine calcium, parathyroid hormone level, CF-PWV value, LV wall thickness, LVMI, aortic and left atrium (LA) diameter, and presence of LVH and CF-PWV > 10 m/s were higher, and serum phosphorus levels were lower. Serum calcium, LA diameter, and LVMI values were closely correlated with CF-PWV. In the ROC analysis, the AUROC was calculated as 0.825 for calcium level to determine the patients with increased CF-PWV. When the serum calcium value was taken as 10 mg/dL, it was determined with CF-PWV > 10 m/s were 79.5% sensitivity and 78.2% specificity.

Conclusion

CF-PWV significantly increases in newly diagnosed hypertensive patients with PHP and significantly related to serum calcium level. To protect against target organ damage, high serum calcium levels should be monitored as well as blood pressure in hypertensive patients with PHP.

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Authors and Affiliations

  1. Department of Medical Oncology, University of Health Sciences - Adana Health Practice and Research Center, Dr. Mithat Özsan Bulvarı Kışla Mah. 4522 Sok. No: 1 Yüreğir, 01230, Adana, Turkey

    Mahmut Buyuksimsek & Ali Ogul

  2. Department of Gastroenterology, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey

    Erdinc Gulumsek

  3. Department of Internal Medicine, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey

    Derya Demirtas, Hilmi Erdem Sumbul, Nurettin Ay & Tayyibe Saler

  4. Department of Cardiology, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey

    Yahya Kemal Icen & Mevlut Koc

Authors
  1. Mahmut Buyuksimsek
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Correspondence to Mahmut Buyuksimsek.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. The study protocol was approved by the local ethics committee.

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All patients included in the study were informed about the study and a revised consent form was signed.

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Buyuksimsek, M., Gulumsek, E., Demirtas, D. et al. Carotid–femoral pulse wave velocity is significantly increased in newly diagnosed hypertensive patients with primary hyperparathyroidism and significantly related with serum calcium level. J Ultrasound 24, 439–446 (2021). https://doi.org/10.1007/s40477-020-00512-4

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