Sandborn WJ, Fazio VW, Feagan BG et al (2003) AGA technical review on perianal Crohn’s disease. Gastroenterology 125:1508–1530
PubMed
Google Scholar
Schwartz DA, Pemberton JH, Sandborn WJ (2001) Diagnosis and treatment of perianal fistulas in Crohn’s disease. Ann Intern Med 135:906–918
CAS
PubMed
Google Scholar
Allan A, Keighley RB (1988) Management of perianal disease. World J Surg 12:198–202
CAS
PubMed
Google Scholar
Hellers G, Bergstrand O, Ewerth S et al (1980) Occurrence and outcome after primary treatment of anal fistulae in Crohn’s disease. Gut 21:525–527
PubMed Central
CAS
PubMed
Google Scholar
Schwartz DA, Loftus E, Tremaine W et al (2002) The natural history of fistulizing Crohn’s disease in Olmsted County, Minnesota. Gastroenterology 122:875–880
PubMed
Google Scholar
Makowiec F, Jehle EC, Starlinger M (1995) Clinical course of perianal fistulas in Crohn’s disease. Gut 37:696–701
PubMed Central
CAS
PubMed
Google Scholar
Sands BE, Anderson FH, Bernstein CN et al (2004) (2004) Infliximab maintenance therapy for fistulizing Crohn’s disease. N Engl J Med 350:876–885
CAS
PubMed
Google Scholar
Parks AG, Gordon PH, Hardcastle JD (1976) A classification of fistula-in-ano. Br J Surg 63:1–12
CAS
PubMed
Google Scholar
Wise PE, Schwartz DA (2012) The evaluation and treatment of Crohn perianal fistulae: EUA, EUS, MRI, and other imaging modalities. Gastroenterol Clin N Am 41:379–391
Google Scholar
Siddiqui MRS, Ashrafian H, Tozer P et al (2012) A diagnostic accuracy meta-analysis of endoanal ultrasound and MRI for perianal fistula assessment. Dis Colon Rectum 55:576–585
PubMed
Google Scholar
Schwartz DA, Wiersema MJ, Dudiak KM et al (2001) A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn’s perianal fistulas. Gastroenterology 121:1064–721995
CAS
PubMed
Google Scholar
Schwartz DA, Herdman CR (2004) Review article: the medical treatment of Crohn’s perianal fistulas. Aliment Pharmacol Ther 19:953–967
CAS
PubMed
Google Scholar
Irvine EJ (1995) Usual therapy improves perianal Crohn’s disease as measured by a new disease activity index. J Clin Gastroenterol 20:27–32
CAS
PubMed
Google Scholar
Present DH, Rutgeerts P, Targan S et al (1999) Infliximab for the treatment of fistulas in patients with Crohn’s disease. N Engl J Med 340:1398–1405
CAS
PubMed
Google Scholar
Ardizzone S, Maconi G, Colombo E et al (2004) Perianal fistulae following Infliximab treatment: clinical and endosonographic outcome. Inflamm Bowel Dis 10:91–96
PubMed
Google Scholar
Van Bodegraven AA, Sloots CEJ, Felt-Bersma RJF, Meuwissen SGM (2002) Endosonographic evidence of persistence of Crohn’s disease associated fistulas after infliximab treatment, irrespective of clinical response. Dis Colon Rectum 45:39–46
PubMed
Google Scholar
Van Assche G, Vanbeckevoort D, Bielen D et al (2003) Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn’s disease. Am J Gastroenterol 98:33–39
Google Scholar
Bell SJ, Halligan S, Windsor ACJ, Williams AB, Wiesel P, Kamm MA (2003) Response of fistulating Crohn’s disease to infliximab treatment assessed by magnetic resonance imaging. Aliment Pharmacol Ther 17:387–393
CAS
PubMed
Google Scholar
Haggett PJ, Moore NR, Shearman JD, Travis SPL, Jewell DP, Mortensen NJ (1995) Pelvic and perineal complications of Crohn’s disease: assessment using magnetic resonance imaging. Gut 36:407–410
PubMed Central
CAS
PubMed
Google Scholar
Tissot O, Bodnar D, Henri L, Dubreuille A, Valette PJ (1996) MR T2 weighted aspect of perianal fistulas. J Radiol 77:253–260
CAS
PubMed
Google Scholar
O’Malley RB, Al-Hawary MM, Kaza RK, Wasnik AP, Liu PS, Hussain HK (2012) Rectal imaging: part 2, Perianal fistula evaluation on pelvic MRI—what the radiologist needs to know. AJR Am J Roentgenol 199:W43–W53
PubMed
Google Scholar
Ziech M, Felt-Bersma R, Stoker J (2009) Imaging of perianal fistulas. Clin Gastroenterol Hepatol 7:1037–1045
PubMed
Google Scholar
Villa C, Pompili G, Franceschelli G et al (2012) Role of magnetic resonance imaging in evaluation of the activity of perianal Crohn’s disease. Eur J Radiol 81:616–622
PubMed
Google Scholar
Ziech MLW, Lavini C, Bipat S et al (2013) Dynamic contrast-enhanced MRI in determining disease activity in perianal fistulizing Crohn disease: a pilot study. AJR Am J Roentgenol 200:W170–W177
PubMed
Google Scholar
Law PJ, Talbot RW, Bartram CI, Northover JMA (1989) Anal endosonography in the evaluation of perianal sepsis and fistula in ano. Br J Surg 76:752–755
CAS
PubMed
Google Scholar
Buchanan GN, Halligan S, Bartram CI, Williams AB, Tarroni D, Cohen CR (2004) Clinical examination, endosonography, and MRI imaging in preoperative assessment of fistula in ano: comparison with outcome-based reference standard. Radiology 233:674–681
PubMed
Google Scholar
Bartram CI, Buchanan G (2003) Imaging anal fistula. Radiol Clin N Am 41:443–457
PubMed
Google Scholar
Caprioli F, Losco A, Viganò C et al (2006) Computer-assisted evaluation of perianal fistula activity by means of anal ultrasound in patients with Crohn’s disease. Am J Gastroenterol 101:1551–1558
PubMed
Google Scholar
Losco A, Viganò C, Conte D, Cesana BM, Basilisco G (2009) Assessing the activity of perianal Crohn’s disease: comparison of clinical indices and computer-assisted anal ultrasound. Inflamm Bowel Dis 15:742–749
PubMed
Google Scholar
Wiese DM, Schwartz DA (2012) Managing perianal Crohn’s disease. Curr Gastroenterol Rep 14:153–161
PubMed
Google Scholar
Seow C, Phillips RK (1991) Insights gained from the management of problematic anal fistulae at St. Mark’s Hospital, 1984–88. Br J Surg 78:539–541
Google Scholar
Garcia-Aguilar J, Belmonte C, Wong WD, Goldberg SM, Madoff RD (1996) Anal fistula surgery. Factors associated with recurrence and incontinence. Dis Colon Rectum 39:723–729
CAS
PubMed
Google Scholar
Spencer JA, Chapple K, Wilson D, Ward J, Windsor AC, Ambrose NS (1998) Outcome after surgery for perianal fistula: predictive value of MR imaging. AJR Am J Roentgenol 171:403–406
CAS
PubMed
Google Scholar
Beets-Tan RG, Beets GL, van der Hoop AG et al (2001) Preoperative MR imaging of anal fistulas: does it really help the surgeon? Radiology 218:75–84
CAS
PubMed
Google Scholar
Buchanan G, Halligan S, Williams A et al (2002) Effect of MRI on clinical outcome of recurrent fistula-in-ano. Lancet 360:1661–1662
PubMed
Google Scholar
Spradlin NM, Wise PE, Herline AJ, Muldoon RL, Rosen M, Schwartz DA (2008) A randomized prospective trial of endoscopic ultrasound to guide combination medical and surgical treatment for Crohn’s perianal fistulas. Am J Gastroenterol 103:2527–2535
PubMed
Google Scholar
Bernstein LH, Frank MS, Brandt LJ, Boley SJ (1980) Healing of perineal Crohn’s disease with metronidazole. Gastroenterology 79:599
CAS
PubMed
Google Scholar
Brandt LJ, Bernstein LH, Boley SJ, Frank MS (1982) Metronidazole therapy for perineal Crohn’s disease: a follow up study. Gastroenterology 83:383–387
CAS
PubMed
Google Scholar
Jacobovits J, Schuster MM (1984) Metronidazole therapy for Crohn’s disease and associated fistulae. Am J Gastroenterol 79:533–540
Google Scholar
Turunen U, Farkilla M, Valtonen V (1993) Long-term outcome of ciprofloxacin treatment in severe perianal or fistulous Crohn’s disease. Gastroenterology 104:A793
Google Scholar
Solomon M, McLeod R, O’Connor B, Steinhart A, Greenberg G, Cohen Z (1993) Combination of ciprofloxacin and metronidazole in severe perineal Crohn’s disease. Can J Gastroenterol 7:571–573
Google Scholar
Thia KT, Mahadevan U, Feagan BG et al (2009) Ciprofloxacin or metronidazole for the treatment of perianal fistulas in patients with Crohn’s disease: a randomized, double-blind, placebo-controlled pilot study. Inflamm Bowel Dis 15:17–24
PubMed
Google Scholar
Korelitz BI, Present DH (1985) Favorable effect of 6-mercaptopurine on fistulae of Crohn’s disease. Dig Dis Sci 30:58–64
CAS
PubMed
Google Scholar
Jeshion WC, Larsen KL, Jawad AF et al (2000) Azathioprine and 6-mercaptopurine for the treatment of perianal Crohn’s disease in children. J Clin Gastroenterol 30:294–298
CAS
PubMed
Google Scholar
Pearson DC, May GR, Fick GH, Sutherland LR (1995) Azathioprine and 6-mercaptopurine in Crohn’s disease. A meta-analysis. Ann Intern Med 123:132–142
CAS
PubMed
Google Scholar
Domenech E, Hinojosa J, Nos P et al (2005) Clinical evolution of luminal and perianal Crohn’s disease after inducing remission with infliximab: how long should patients be treated? Aliment Pharmacol Ther 22:1107–1113
CAS
PubMed
Google Scholar
Colombel JF, Schwartz DA, Sandborn WJ et al (2009) Adalimumab for the treatment of fistulas in patients with Crohn’s disease. Gut 58:940–948
PubMed Central
CAS
PubMed
Google Scholar
Hinojosa J, Gomollon F, Garcia S et al (2007) Efficacy and safety of short-term adalimumab treatment in patients with active Crohn’s disease who lost response or showed intolerance to infliximab: a prospective, open-label, multicentre trial. Aliment Pharmacol Ther 25:409–418
CAS
PubMed
Google Scholar
Lichtiger S, Binion DG, Wolf DC et al (2010) The CHOICE trial: adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn’s disease who failed prior infliximab therapy. Aliment Pharmacol Ther 32:1228–1239
CAS
PubMed
Google Scholar
Linares L, Moreira LF, Andrews H, Allan RN, Alexander-Williams J, Keighley MR (1988) Natural history and treatment of anorectal strictures complicating Crohn’s disease. Br J Surg 75:653–655
CAS
PubMed
Google Scholar
Homan WP, Tang C, Thorgjarnarson B (1976) Anal lesions complicating Crohn disease. Arch Surg 111:1333–1335
CAS
PubMed
Google Scholar
Williams JG, Hughes LE (1990) Abdominoperineal resection for severe perianal Crohn’s disease. Dis Colon Rectum 33:402–407
CAS
PubMed
Google Scholar
Pescatori M, Interisano A, Basso L et al (1995) Management of perianal Crohn’s disease. Results of a multicenter study in Italy. Dis Colon Rectum 38:121–124
CAS
PubMed
Google Scholar
Morrison JG, Gathright JBJ, Ray JE, Ferrari BT, Hicks TC, Timmcke AE (1989) Surgical management of anorectal fistulas in Crohn’s disease. Dis Colon Rectum 32:492–496
CAS
PubMed
Google Scholar
Bernard D, Morgan S, Tasse D (1986) Selective surgical management of Crohn’s disease of the anus. Can J Surg 29:318–321
CAS
PubMed
Google Scholar
Lockhart-Mummery HE (1985) Anal lesions in Crohn’s disease. Br J Surg 72:S95–S96
PubMed
Google Scholar
Pritchard TJ, Schoetz DJJ, Roberts PL, Murray JJ, Coller JA, Veidenheimer MC (1990) Perirectal abscess in Crohn’s disease. Drainage and outcome. Dis Colon Rectum 33:933–937
CAS
PubMed
Google Scholar
Makowiec F, Jehle EC, Becker HD, Starlinger M (1997) Perianal abscess in Crohn’s disease. Dis Colon Rectum 40:443–450
CAS
PubMed
Google Scholar
White RA, Eisenstat TE, Rubin RJ, Salvati EP (1990) Seton management of complex anorectal fistulas in patients with Crohn’s disease. Dis Colon Rectum 33:587–589
CAS
PubMed
Google Scholar
Goodsall DH, Miles WE (1900) Ano-rectal fistula. In: Goodsall DH, Miles WE (eds) Diseases of the anus and rectum. Longmans, Greens and Co., London, pp 92–137
Google Scholar
Coremans G, Dockx S, Wyndaele J, Hendrickx A (2003) Do anal fistulas in Crohn’s disease behave differently and defy Goodsall’s rule more frequently than fistulas that are cryptoglandular in origin? Am J Gastroenterol 12:2732–2735
Google Scholar
Fry RD, Shemesh EI, Kodner IJ, Timmcke A (1989) Techniques and results in the management of anal and perianal Crohn’s disease. Surg Gynecol Obstet 168:42–48
CAS
PubMed
Google Scholar
Williamson PR, Hellinger MD, Larach SW, Ferrara A (1995) Twenty-year review of the surgical management of perianal Crohn’s disease. Dis Colon Rectum 38:389–392
CAS
PubMed
Google Scholar
Fuhrman GM, Larach SW (1989) Experience with perirectal fistulas in patients with Crohn’s disease. Dis Colon Rectum 32:847–848
CAS
PubMed
Google Scholar
Koganei K, Sugita A, Harada H, Fukushima T, Shimada H (1995) Seton treatment for perianal Crohn’s fistulas. Surg Today 25:32–36
CAS
PubMed
Google Scholar
Keighley MR, Allan RN (1986) Current status and influence of operation on perianal Crohn’s disease. Int J Colorectal Dis 1:104–107
CAS
PubMed
Google Scholar
Williams JG, Rothenberger DA, Nemer FD, Goldber SM (1991) Fistula-in-ano in Crohn’s disease. Results of aggressive surgical treatment. Dis Colon Rectum 34:378–384
CAS
PubMed
Google Scholar
Winter AM, Banks PA, Petros JG (1993) Healing of transsphincteric perianal fistulas in Crohn’s disease using a new technique. Am J Gastroenterol 88:2022–2025
CAS
PubMed
Google Scholar
van Dongen LM, Lubbers EJ (1986) Perianal fistulas in patients with Crohn’s disease. Arch Surg 121:1187–1190
PubMed
Google Scholar
Lapidus A, Bernell O, Hellers G, Lofberg R (1998) Clinical course of colorectal Crohn’s disease: a 35-year follow-up study of 507 patients. Gastroenterology 114:1151–1160
CAS
PubMed
Google Scholar
Hyder SA (2006) Fistulating anal Crohn’s disease: results of combined surgical and infliximab treatment. Dis Colon Rectum 49:1837–1841
PubMed
Google Scholar
Sangwan YP, Schoetz DJJ, Murray JJ, Roberts PL, Coller JA (1996) Perianal Crohn’s disease. Results of local surgical treatment. Dis Colon Rectum 39:529–535
CAS
PubMed
Google Scholar
Michelassi F, Melis M, Rubin M, Hurst RD (2000) Surgical treatment of anorectal complications in Crohn’s disease. Surgery 128:597–603
CAS
PubMed
Google Scholar
Faucheron JL, Saint-Marc O, Guibert L, Parc R (1996) Long-term seton drainage for high anal fistulas in Crohn’s disease: a sphincter saving operation? Dis Colon Rectum 39:208–211
CAS
PubMed
Google Scholar
Pearl RK, Andrews JR, Orsay CP et al (1993) Role of the seton in the management of anorectal fistulas. Dis Colon Rectum 36:573–579
CAS
PubMed
Google Scholar
Nordgren S, Fasth S, Hulten L (1992) Anal fistulas in Crohn’s disease: incidence and outcome of surgical treatment. Int J Colorectal Dis 7:214–218
CAS
PubMed
Google Scholar
Matos D, Lunniss PJ, Phillips Rk (1993) Total sphincter conservation in high fistula in ano: results of a new approach. Br J Surg 80:802–804
CAS
PubMed
Google Scholar
Iesalnieks I, Gaertner WB, Glass H et al (2010) Fistula associated anal adenocarcinoma in Crohn’s disease. Inflamm Bowel Dis 16:1643–1648
PubMed
Google Scholar
Thomas M, Bienkowski R, Vandermeer TJ, Trostle D, Cagir B (2010) Malignant transformation in perianal fistulas of Crohn’s disease: a systematic review of literature. J Gastrointest Surg 14:66–73
PubMed
Google Scholar
Sonoda T, Hull T, Piedmonte MR, Fazio VW (2002) Outcomes of primary repair of anorectal and rectovaginal fistulas using the endorectal advancement flap. Dis Colon Rectum 45:1622–1628
PubMed
Google Scholar
Zimmerman DD, Delemarre JB, Gosselink MP, Hop WC, Briel JW, Schouten WR (2003) Smoking affects the outcome of transanal mucosal advancement flap repair of trans-sphincteric fistulas. Br J Surg 90:351–354
CAS
PubMed
Google Scholar
Jarrar A, Church J (2011) Advancement flap repair: a good option for complex anorectal fistulas. Dis Colon Rectum 54:1537–1541
PubMed
Google Scholar
McKee RF, Keenan RA (1996) Perianal Crohn’s disease—is it all bad news? Dis Colon Rectum 39:136–142
CAS
PubMed
Google Scholar
Jones IT, Fazio VW, Jagelman DG (1987) The use of transanal rectal advancement flaps in the management of fistulas involving the anorectum. Dis Colon Rectum 30:919–923
CAS
PubMed
Google Scholar
Lewis P, Bartolo DC (1990) Treatment of trans-sphincteric fistulae by full thickness anorectal advancement flaps. Br J Surg 77:1187–1189
CAS
PubMed
Google Scholar
Makowiec F, Jehle EC, Becker HD, Starlinger M (1995) Clinical course after transanal advancement flap repair of perianal fistula in patients with Crohn’s disease. Br J Surg 82:603–606
CAS
PubMed
Google Scholar
Joo JS, Weiss EG, Nogueras JJ, Wexner SD (1998) Endorectal advancement flap in perianal Crohn’s disease. Am Surg 64:147–150
CAS
PubMed
Google Scholar
Marchesa P, Hull TL, Fazio VW (1998) Advancement sleeve flaps for treatment of severe perianal Crohn’s disease. Br J Surg 85:1695–1698
CAS
PubMed
Google Scholar
Mizrahi N, Wexner SD, Zmora O et al (2002) Endorectal advancement flaps: are they predictors of failure? Dis Colon Rectum 45:1616–1621
PubMed
Google Scholar
Tozer PJ, Burling D, Gupta A, Phillips RK, Hart AL (2011) Review article: medical, surgical and radiological management of perianal Crohn’s fistulas. Aliment Pharmacol Ther 33:5–22
CAS
PubMed
Google Scholar
O’leary DP, Milroy CE, Durdey P (1998) Definitive repair of anovaginal fistula in Crohn’s disease. Ann R Coll Surg Engl 80:250–252
PubMed Central
PubMed
Google Scholar
Hull TL, Fazio VW (1997) Surgical approaches to low anovaginal fistula in Crohn’s disease. Am J Surg 173:95–98
CAS
PubMed
Google Scholar
Ozuner G, Hull TL, Cartmill J, Fazio VW (1996) Long-term analysis of the use of transanal rectal advancement flaps for complicated anorectal/vaginal fistulas. Dis Colon Rectum 39:10–14
CAS
PubMed
Google Scholar
Simmang CL, Lacey SW, Huber PJJ (1998) Rectal sleeve advancement: repair of rectovaginal fistula associated with anorectal stricture in Crohn’s disease. Dis Colon Rectum 41:787–789
CAS
PubMed
Google Scholar
Sher ME, Bauer JJ, Gelernt I (1991) Surgical repair of rectovaginal fistulas in patients with Crohn’s disease: transvaginal approach. Dis Colon Rectum 34:641–648
CAS
PubMed
Google Scholar
Bauer JJ, Sher ME, Jaffin H, Present D, Gelerent I (1991) Transvaginal approach for repair of rectovaginal fistulae complicating Crohn’s disease. Ann Surg 213:151–158
PubMed Central
CAS
PubMed
Google Scholar
Cintron JR, Park JJ, Orsay CP et al (2000) Repair of fistulas-in-ano using fibrin adhesive: long-term follow-up. Dis Colon Rectum 43:944–949
CAS
PubMed
Google Scholar
Lindsey I, Smilgin-Humphreys MM, Cunningham C, Mortensen NJ, George BD (2002) A randomized, controlled trial of fibrin glue vs. conventional treatment for anal fistula. Dis Colon Rectum 45:1608–1615
PubMed
Google Scholar
Zmora O, Mizrahi N, Rotholtz N et al (2003) Fibrin glue sealing in the treatment of perineal fistulas. Dis Colon Rectum 46:584–589
PubMed
Google Scholar
Chung W, Ko D, Sun C, Raval MJ, Brown CJ, Phang PT (2010) Outcomes of anal fistula surgery in patients with inflammatory bowel disease. Am J Surg 199:609–613
PubMed
Google Scholar
de Parades V, Far HS, Etienney I, Zeitoun JD, Atienza P, Bauer P (2010) Seton drainage and fibrin glue injection for complex anal fistulas. Colorectal Dis 12:459–463
PubMed
Google Scholar
Ky AJ, Sylla P, Steinhagen R, Steinhagen E, Khaitov S, Ly EK (2008) Collagen fistula plug for the treatment of anal fistulas. Dis Colon Rectum 51:838–843
PubMed
Google Scholar
Christoforidis D, Etzioni DA, Goldberg SM, Madoff RD, Mellgren A (2008) Treatment of complex anal fistulas with the collagen fistula plug. Dis Colon Rectum 51:1482–1487
PubMed
Google Scholar
Schwandner O, Fuerst A (2009) Preliminary results on efficacy in closure of transsphincteric and rectovaginal fistulas associated with Crohn’s disease using new biomaterials. Surg Innov 16:162–168
PubMed
Google Scholar
Safar B, Jobanputra S, Sands D, Weiss EG, Nogueras JJ, Wexner SD (2009) Anal fistula plug: initial experience and outcomes. Dis Colon Rectum 52:248–252
PubMed
Google Scholar
Lichtiger S (2001) Healing of perianal fistulae by local injection of antibody to TNF. Gastroenterology 120(suppl 1):A621
Google Scholar
Poggioli G, Laureti S, Pierangeli F et al (2005) Local injection of Infliximab for the treatment of perianal Crohn’s disease. Dis Colon Rectum 48:768–774
CAS
PubMed
Google Scholar
Asteria CR, Ficari F, Bagnoli S, Milla M, Tonelli F (2006) Treatment of perianal fistulas in Crohn’s disease by local injection of antibody to TNF-alpha accounts for a favourable clinical response in selected cases: a pilot study. Scand J Gastroenterol 41:1064–1072
CAS
PubMed
Google Scholar
Poggioli G, Laureti S, Pierangeli F et al (2010) Local injection of adalimumab for perianal Crohn’s disease: better than infliximab? Inflamm Bowel Dis 16:1631
CAS
PubMed
Google Scholar
Tonelli F, Giudici F, Asteria CF (2012) Effectiveness and safety of local adalimumab injection in patients with fistulizing perianal Crohn’s disease: a pilot study. Dis Colon Rectum 55:870–875
PubMed
Google Scholar
Loeffler T, Welsch T, Muehl S, Hinz U, Schmidt J, Kienle P (2009) Long-term success rate after surgical treatment of anorectal and rectovaginal fistulas in Crohn’s disease. Int J Colorectal Dis 24:521–526
Google Scholar
Regueiro M, Mardini H (2003) Treatment of perianal fistulizing Crohn’s disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement. Inflamm Bowel Dis 9:98–103
PubMed
Google Scholar
Uchino M, Ikeuchi H, Bando T et al (2011) Long-term efficacy of infliximab maintenance therapy for perianal Crohn’s disease. World J Gastroenterol 17:1174–1179
PubMed Central
PubMed
Google Scholar
El-Gazzaz G, Hull T, Church JM (2012) Biological immunomodulators improve the healing rate in surgically treated perianal Crohn’s fistulas. Colorectal Dis 14:1217–1223
CAS
PubMed
Google Scholar
Sciaudone G, Di Stazio C, Limongelli P et al (2010) Treatment of complex perianal fistulas in Crohn disease: infliximab, surgery or combined approach. Can J Surg 53:299–304
PubMed Central
PubMed
Google Scholar
Topstad DR, Panaccione R, Heine JA, Johnson DR, MacLean AR, Buie WD (2003) Combined seton placement, infliximab infusion, and maintenance immunosuppressives improve healing rate in fistulizing anorectal Crohn’s disease: a single center experience. Dis Colon Rectum 46:577–583
PubMed
Google Scholar
van der Hagen SJ, Baeten CG, Soeters PB, Russel MG, Beets-Tan RG, van Gemert WG (2005) Anti-TNF-alpha (infliximab) used as induction treatment in case of active proctitis in a multistep strategy followed by definitive surgery of complex anal fistulas in Crohn’s disease: a preliminary report. Dis Colon Rectum 48:758–767
PubMed
Google Scholar
Guidi L, Ratto C, Semeraro S et al (2008) Combined therapy with infliximab and seton drainage for perianal fistulizing Crohn’s disease with anal endosonographic monitoring: a single-centre experience. Tech Coloproctol 12:111–117
CAS
PubMed
Google Scholar
Tanaka S, Matsuo K, Sasaki T et al (2010) Clinical advantages of combined seton placement and infliximab maintenance therapy for perianal fistulizing Crohn’s disease: when and how were the seton drains removed? Hepatogastroenterology 57:3–7
CAS
PubMed
Google Scholar
Talbot C, Sagar PM, Johnston MJ, Finan PJ, Burke D (2005) Infliximab in the surgical management of complex fistulating anal Crohn’s disease. Colorectal Dis 7:164–168
CAS
PubMed
Google Scholar
Antakia R, Shorthouse AJ, Robinson K, Lobo AJ (2013) Combined modality treatment for complex fistulating perianal Crohn’s disease. Colorectal Dis 15:210–216
CAS
PubMed
Google Scholar
Rasul I, Wilson SR, MacRae H, Irwin S, Greenberg GR (2004) Clinical and radiological responses after infliximab treatment for perianal fistulizing Crohn’s disease. Am J Gastroenterol 99:82–88
CAS
PubMed
Google Scholar
Gligorijević V, Spasić N, Bojić D et al (2010) The role of pelvic MRI in assessment of combined surgical and infliximab treatment for perianal Crohn’s disease. Acta Chir Iugosl 57:89–95
PubMed
Google Scholar
Karmiris K, Bielen D, Vanbeckevoort D et al (2011) Long-term monitoring of infliximab therapy for perianal fistulizing Crohn’s disease by using magnetic resonance imaging. Clin Gastroenterol Hepatol 9:130–136
CAS
PubMed
Google Scholar
Savoye-Collet C, Savoye G, Koning E, Dacher JN, Lerebours E (2011) Fistulizing perianal Crohn’s disease: contrast-enhanced magnetic resonance imaging assessment at 1 year on maintenance anti-TNF-alpha therapy. Inflamm Bowel Dis 17:1751–1758
CAS
PubMed
Google Scholar
Ng SC, Plamondon S, Gupta A et al (2009) Prospective evaluation of anti-tumor necrosis factor therapy guided by magnetic resonance imaging for Crohn’s perineal fistulas. Am J Gastroenterol 104:2973–2986
CAS
PubMed
Google Scholar
Tozer P, Ng SC, Siddiqui MR et al (2012) Long-term MRI-guided combined anti-TNF-α and thiopurine therapy for Crohn’s perianal fistulas. Inflamm Bowel Dis 18:1825–1834
PubMed
Google Scholar
Schwartz DA, White CM, Wise PE, Herline AJ (2005) Use of endoscopic ultrasound to guide combination medical and surgical therapy for patients with Crohn’s perianal fistulas. Inflamm Bowel Dis 11:727–732
PubMed
Google Scholar
Gaertner WB, Decaini A, Mellgren A et al (2007) Does infliximab infusion impact results of operative treatment for Crohn’s perianal fistulas? Dis Colon Rectum 50:1754–1760
PubMed
Google Scholar
Yamamoto T, Allan RN, Keighley MR (2000) Effect of fecal diversion alone on perianal Crohn’s disease. World J Surg 24:1258–1262
CAS
PubMed
Google Scholar
Hong MKH, Lynch AC, Bell S et al (2010) Faecal diversion in the management of perianal Crohn’s disease. Colorectal Dis 13:171–176
Google Scholar
Laukoetter MG, Mennigen R, Hannig CM et al (2011) Intestinal cancer risk in Crohn’s disease: a meta-analysis. J Gastrointest Surg 15:576–583
PubMed
Google Scholar
Ogawa H, Haneda S, Shibata C et al (2013) Adenocarcinoma associated with perianal fistulas in Crohn’s disease. Anticancer Res 33:685–690
PubMed
Google Scholar
Devon KM, Brown CJ, Burnstein M, McLeod RS (2009) Cancer of the anus complicating perianal Crohn’s disease. Dis Colon Rectum 52:211–216
CAS
PubMed
Google Scholar
Cirincione E, Gorfine SR, Bauer JJ (2000) Is Hartmann’s procedure safe in Crohn’s disease? Report of three cases. Dis Colon Rectum 43:544–547
CAS
PubMed
Google Scholar