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Cutaneous Tuberculosis: a Review of the Current Literature

  • Cutaneous Mycobacterial Diseases of the Skin and Soft Tissues (C Franco-Paredes, Section Editor)
  • Published:
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Abstract

Purpose of review

This review summarizes the literature currently available for cutaneous tuberculosis (CTB), as well as providing data for clinical utility.

Recent findings

Available studies in CTB are scarce; however, they provide important information about efficacy and outcome in clinical practice.

Summary

We can detect differences in the clinical aspect and disease evolution; this is due to the individual immunity, environmental factors, and the type of inoculum. Treatment options for CTB are currently limited to the conventional oral therapy and the occasional surgical intervention in cases where needed. The development of multidrug-resistant strains and extremely resistant to drugs has also threatened treatment effectiveness. The aim of the article is to review the current status of CTB, in addition to a better knowledge of the molecular and cellular mechanisms regulating host-agent interaction.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Nadjane Batista Lacerda S, Cristina de Abreu Temoteo R, Maria Ribeiro Monteiro de Figueiredo T, Darliane Tavares de Luna F, Alves Nunes de Sousa M, Carlos de Abreu L, et al. Individual and social vulnerabilities upon acquiring tuberculosis: a literature systematic review. Int Arch Med. 2014;7:35.

    Article  PubMed  PubMed Central  Google Scholar 

  2. • Dias MF, Bernardes Filho F, Quaresma MV, Nascimento LV, Nery JA, Azulay DR. Update on cutaneous tuberculosis. An Bras Dermatol. 2014;89(6):925–38. This paper includes an overview of the disease.

    Article  PubMed  PubMed Central  Google Scholar 

  3. • van Zyl L, du Plessis J, Viljoen J. Cutaneous tuberculosis overview and current treatment regimens. Tuberculosis (Edinb). 2015;95(6):629–38. This paper includes an overview of the disease.

    Article  Google Scholar 

  4. Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children. 2nd ed. Geneva: World Health Organization; 2014.

  5. • Melsew YA, Doan TN, Gambhir M, Cheng AC, McBryde E, Trauer JM. Risk factors for infectiousness of patients with tuberculosis: a systematic review and meta-analysis. Epidemiol Infect. 2018;1-9. This paper shows a summary of the most commonly seen risk factors for tuberculosis.

  6. Mwiru RS, Nagu TJ, Kaduri P, Fawzi W, Mugusi F. Prevalence and factors associated with alcohol drinking among HIV and tuberculosis co-infected patients in Dar es Salaam, Tanzania. AIDS Care. 2018;30(2):173–7.

    Article  PubMed  Google Scholar 

  7. Nakiwala JK, Walker NF, Diedrich CR, Worodria W, Meintjes G, Wilkinson RJ, et al. Neutrophil activation and enhanced release of granule products in HIV-TB immune reconstitution inflammatory syndrome. J Acquir Immune Defic Syndr. 2018;77(2):221–9.

    PubMed  CAS  Google Scholar 

  8. GBD. 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: A systematic analysis for the global burden of disease study 2016. Lancet. 2017;390(10100):1151–210.

    Article  Google Scholar 

  9. •• Bainomugisa A, Lavu E, Hiashiri S, Majumdar S, Honjepari A, Moke R, et al. Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades. Microb Genom. 2018; https://doi.org/10.1099/mgen.0.000147. This paper gives important clues for the mechanisms of drug-resistance in tuberculosis.

  10. Zhu B, Dockrell HM, Ottenhoff THM, Evans TG, Zhang Y. Tuberculosis vaccines: opportunities and challenges. Respirology. 2018;23:359–68. https://doi.org/10.1111/resp.13245.

    Article  PubMed  Google Scholar 

  11. Baek SO, Ko HS, Han HH. BCG vaccination-induced suppurative lymphadenitis: four signs to pay attention to. Int Wound J. 2017;14(6):1385–7.

    Article  PubMed  Google Scholar 

  12. Sehgal VN, Gupta RP, Karmakar S, Logani KB, Jain S. In situ characterization of lymphocytic immunophenotypes and interleukin-2 receptors in cutaneous tuberculosis and leprosy--a comparative evaluation. Clin Exp Dermatol. 1994;19(4):312–6.

    Article  PubMed  CAS  Google Scholar 

  13. Bell LCK, Noursadeghi M. Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection. Nat Rev Microbiol. 2018;16(2):80–90.

    Article  PubMed  CAS  Google Scholar 

  14. Parlato S, Chiacchio T, Salerno D, Petrone L, Castiello L, Romagnoli G, et al. Impaired IFN-α-mediated signal in dendritic cells differentiates active from latent tuberculosis. PLoS One. 2018;13(1):e0189477.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Kennedy AE, O'Mahony J, Byrne N, MacSharry J, Sayers RG. Is TB testing associated with increased blood interferon-gamma levels? Front Vet Sci. 2017;4:176.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Ramaraj SM, Nagendra K, Gopal G, Majgi SM. Need for different cutoff values for reading mantoux test with 2TU and 5TU PPD. Indian J Pediatr. 2017;84(9):677–80.

    Article  PubMed  Google Scholar 

  17. Marín D, Marín N, Del Corral H, López L, Ramirez-Agudelo ME, Rojas CA, et al. PPD-induced monocyte mitochondrial damage is associated with a protective effect to develop tuberculosis in BCG vaccinated individuals: a cohort study. PLoS One. 2017;12(2):e0171930.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. •• Hill MK, Sanders CV. Cutaneous tuberculosis. Microbiol Spectr. 2017;5(1) https://doi.org/10.1128/microbiolspec.TNMI7-0010-2016. This paper gives important strategies for treating cutaneous tuberculosis.

  19. • Scollard DM, Dacso MM, Abad-Venida ML. Tuberculosis and leprosy: classical granulomatous diseases in the twenty-first century. Dermatol Clin. 2015;33(3):541–62. This paper gives a complete review of leprosy and tuberculosis.

    Article  PubMed  CAS  Google Scholar 

  20. Micali G, Lacarrubba F, Massimino D, Schwartz RA. Dermatoscopy: alternative uses in daily clinical practice. J Am Acad Dermatol. 2011;64(6):1135–46.

    Article  PubMed  Google Scholar 

  21. •• Chakrabortty R, Rahman MA, Ferdousi KR, Paul BK. Cutaneous tuberculosis: an update. Mymensingh Med J. 2016;25(2):385–91. An important review of the disease focusing on therapeutic options.

    PubMed  CAS  Google Scholar 

  22. Braun-Falco O, Thomas P. The tuberculid concept from the current viewpoint. Hautarzt. 1995;46(6):383–7.

    Article  PubMed  CAS  Google Scholar 

  23. Hallensleben ND, de Vries HJ, Lettinga KD, Scherpbier HJ. Tuberculids: cutaneous indicator diseases of Mycobacterium tuberculosis infection in young patients. J Eur Acad Dermatol Venereol. 2016;30(9):1590–3.

    Article  PubMed  CAS  Google Scholar 

  24. Suárez Castañón C, Pérez Méndez C, Alvarez Cuesta CC, Corrales Canel B, Blanco Costa MI. Erythema induratum of Bazin associated to Mycobacterium tuberculosis infection. Arch Argent Pediatr. 2012;110(3):e43–6.

    Article  PubMed  Google Scholar 

  25. Boortalary T, Misra K, McNish S, Jones D, Shanmugam VK. Prevalence of positive QuantiFERON gold in-tube testing in Hidradenitis suppurativa. J Dermatolog Treat 2018;1–16.

  26. Matono T, Nishijima T, Teruya K, Morino E, Takasaki J, Gatanaga H, et al. Substantially higher and earlier occurrence of anti-tuberculosis drug-related adverse reactions in HIV coinfected tuberculosis patients: a matched-cohort study. AIDS Patient Care STDs. 2017;31(11):455–62.

    Article  PubMed  Google Scholar 

  27. Yoshioka Y, Hanafusa T, Namiki T, Nojima K, Amano M, Tokoro S, et al. Drug-induced hypersensitivity syndrome by ethambutol: a case report. J Dermatol. 2016;43(8):971–2.

    Article  PubMed  Google Scholar 

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Correspondence to Alexandro Bonifaz.

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Conflict of Interest

Andrés Tirado-Sánchez and Alexandro Bonifaz declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Cutaneous Mycobacterial Diseases of the Skin and Soft Tissues

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Tirado-Sánchez, A., Bonifaz, A. Cutaneous Tuberculosis: a Review of the Current Literature. Curr Trop Med Rep 5, 67–76 (2018). https://doi.org/10.1007/s40475-018-0140-z

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