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The Therapeutic Potential of Non-invasive Neurostimulation for Motor Skill Learning in Children with Neurodevelopmental Disorders

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Abstract

Purpose of Review

Non-invasive neurostimulation is becoming increasingly popular in rehabilitation, as it may enhance the brain’s natural learning processes, potentially increasing the effectiveness of movement interventions. The current paper provides a review of studies that have investigated the application of transcranial direct current stimulation (tDCS) in pediatric populations with neurodevelopmental disorders (NDD) complicated by motor impairment.

Recent Findings

Proof of principle studies indicate that tDCS can positively influence motor learning in children. The application of tDCS across pediatric populations with NDD is in its early stages.

Summary

We emphasize the need for caution and further research investigating the therapeutic potential of tDCS in children with NDD and motor impairment. Indications of efficacy will require carefully designed trials before conclusions of effectiveness can be made. Optimal tDCS protocols may differ across both disorders and individuals. Protocol parameters which produce clinically significant improvements will become clearer with further high-quality evidence.

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References

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  1. Wolpert DM, Ghahramani Z, Flanagan JR. Perspectives and problems in motor learning. Trends Cogn Sci. 2001;5(11):487–94. https://doi.org/10.1016/S1364-6613(00)01773-3.

    Article  PubMed  Google Scholar 

  2. Roetert EP, Jefferies SC. Embracing physical literacy. J Phys Edu Recreation Dance. 2014;85(8):38–40. https://doi.org/10.1080/07303084.2014.948353.

    Article  Google Scholar 

  3. Giblin S, Collins D, Button C. Physical literacy: importance, assessment and future directions. Sports Med. 2014;44(9):1177–84. https://doi.org/10.1007/s40279-014-0205-7.

    Article  PubMed  Google Scholar 

  4. Sanes JN. Neocortical mechanisms in motor learning. Curr Opin Neurobiol. 2003;13(2):225–31. https://doi.org/10.1016/S0959-4388(03)00046-1.

    Article  CAS  PubMed  Google Scholar 

  5. Hebb, D. O. (1949). The organization of behavior: a neuropsychological theory.

  6. Nicoll RA. A brief history of long-term potentiation. Neuron. 2017;93(2):281–90. https://doi.org/10.1016/j.neuron.2016.12.015.

    Article  CAS  PubMed  Google Scholar 

  7. Hess G, Donoghue JP. Long-term potentiation of horizontal connections provides a mechanism to reorganize cortical motor maps. J Neurophysiol. 1994;71(6):2543–7. https://doi.org/10.1152/jn.1994.71.6.2543.

    Article  CAS  PubMed  Google Scholar 

  8. Dayan E, Cohen LG. Neuroplasticity subserving motor skill learning. Neuron. 2011;72(3):443–54. https://doi.org/10.1016/j.neuron.2011.10.008.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Zatorre RJ, Fields RD, Johansen-Berg H. Plasticity in gray and white. Nat Neurosci. 2012;15(4):528–36. https://doi.org/10.1038/nn.3045.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Halsband U, Lange RK. Motor learning in man: a review of functional and clinical studies. Journal of Physiology-Paris. 2006;99(4–6):414–24. https://doi.org/10.1016/j.jphysparis.2006.03.007.

    Article  Google Scholar 

  11. Hardwick RM, Rottschy C, Miall RC, Eickhoff SB. A quantitative meta-analysis and review of motor learning in the human brain. NeuroImage. 2013;67:283–97. https://doi.org/10.1016/j.neuroimage.2012.11.020.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Rushworth MFS, Noonan MP, Boorman ED, Walton ME, Behrens TE. Frontal cortex and reward-guided learning and decision-making. Neuron. 2011;70(6):1054–69. https://doi.org/10.1016/j.neuron.2011.05.014.

    Article  CAS  Google Scholar 

  13. Levac D, Wishart L, Missiuna C, Wright V. The application of motor learning strategies within functionally based interventions for children with neuromotor conditions. Pediatr Phys Ther. 2009;21(4):345–55. https://doi.org/10.1097/PEP.0b013e3181beb09d.

    Article  PubMed  Google Scholar 

  14. Kitago, T. O. M. O. K. O., & Krakauer, J. W. (2013). Motor learning principles for neurorehabilitation. In Handbook of Clinical Neurology (Vol. 110, pp. 93–103). Elsevier. https://doi.org/10.1016/B978-0-444-52901-5.00008-3.

  15. Ciechanski P, Kirton A. Pediatric brain stimulation mapping and modulating the developing brain chapter 5 - transcranial direct-current stimulation (tDCS): principles and emerging applications in children. In: Pediatric brain stimulation. Oxford: Academic Press; 2016. p. 85–115. https://doi.org/10.1016/B978-0-12-802001-2.00005-9.

    Chapter  Google Scholar 

  16. Dayan E, Censor N, Buch ER, Sandrini M, Cohen LG. Noninvasive brain stimulation: from physiology to network dynamics and back. Nat Neurosci. 2013;16(7):838–44. https://doi.org/10.1038/nn.3422.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Rajapakse T, Kirton A. Non-invasive brain stimulation in children: applications and future directions. Transl Neurosci. 2013;4(2):217–33. https://doi.org/10.2478/s13380-013-0116-3.

  18. • Bikson M, Grossman P, Thomas C, Zannou AL, Jiang J, Adnan T, et al. Safety of transcranial direct current stimulation: evidence based update 2016. Brain Stimul: Basic, Translational, and Clinical Research in Neuromodulation. 2016;9(5):641–61. https://doi.org/10.1016/j.brs.2016.06.004 This review provides support for the safety, tolerability, and feasibility of tDCS in both typically developing and vulnerable populations. Alongside a comprehensive overview of both animal and human literature, findings from this study encourages further research examining the therapeutic benefits of tDCS.

    Article  Google Scholar 

  19. Krishnan C, Santos L, Peterson MD, Ehinger M. Safety of noninvasive brain stimulation in children and adolescents. Brain Stimul. 2015;8(1):76–87. https://doi.org/10.1016/j.brs.2014.10.012.

    Article  PubMed  Google Scholar 

  20. Palm U, Segmiller FM, Epple AN, Freisleder F-J, Koutsouleris N, Schulte-Körne G, et al. Transcranial direct current stimulation in children and adolescents: a comprehensive review. J Neural Transm. 2016;123(10):1219–34. https://doi.org/10.1007/s00702-016-1572-z.

    Article  PubMed  Google Scholar 

  21. Gillick BT, Feyma T, Menk J, Usset M, Vaith A, Wood TJ, et al. Safety and feasibility of transcranial direct current stimulation in pediatric hemiparesis: randomized controlled preliminary study. Phys Ther. 2015;95(3):337–49. https://doi.org/10.2522/ptj.20130565.

    Article  PubMed  Google Scholar 

  22. Ciechanski P, Kirton A. Pediatric brain stimulation mapping and modulating the developing brain chapter 7 - pediatric issues in neuromodulation: safety, tolerability and ethical considerations. In: Pediatric brain stimulation. Oxford: Academic Press; 2016. p. 85–115. https://doi.org/10.1016/B978-0-12-802001-2.00005-9.

    Chapter  Google Scholar 

  23. Liebetanz D, Nitsche MA, Tergau F, Paulus W. Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain. 2002;125(10):2238–47. https://doi.org/10.1093/brain/awf238.

    Article  PubMed  Google Scholar 

  24. Kronberg G, Bridi M, Abel T, Bikson M, Parra LC. Direct current stimulation modulates LTP and LTD: activity dependence and dendritic effects. Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation. 2017;10(1):51–8. https://doi.org/10.1016/j.brs.2016.10.001.

    Article  Google Scholar 

  25. Stagg CJ, Nitsche MA. Physiological basis of transcranial direct current stimulation. Neuroscientist. 2011;17(1):37–53. https://doi.org/10.1177/1073858410386614.

    Article  PubMed  Google Scholar 

  26. Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol. 2004;527(3):633–9. https://doi.org/10.1111/j.1469-7793.2000.t01-1-00633.x.

    Article  Google Scholar 

  27. Nitsche MA, Paulus W. Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology. 2001;57(10):1899–901.

    Article  CAS  Google Scholar 

  28. Ciechanski P, Carlson H, Yu S, Kirton A. Modeling transcranial direct-current stimulation-induced electric fields in children and adults. Front Hum Neurosci. 2018;12:268. https://doi.org/10.3389/fnhum.2018.00268.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Ambrus GG, Al-Moyed H, Chaieb L, Sarp L, Antal A, Paulus W. The fade-in – short stimulation – fade out approach to sham tDCS – reliable at 1 mA for naïve and experienced subjects, but not investigators. Brain Stimulation. 2012;5(4):499–504. https://doi.org/10.1016/j.brs.2011.12.001.

    Article  PubMed  Google Scholar 

  30. Jacobson L, Koslowsky M, Lavidor M. tDCS polarity effects in motor and cognitive domains: a meta-analytical review. Exp Brain Res. 2012;216(1):1–10. https://doi.org/10.1007/s00221-011-2891-9.

    Article  PubMed  Google Scholar 

  31. Flöel A. tDCS-enhanced motor and cognitive function in neurological diseases. NeuroImage. 2014;85:934–47. https://doi.org/10.1016/j.neuroimage.2013.05.098.

    Article  PubMed  Google Scholar 

  32. Butler AJ, Shuster M, O’Hara E, Hurley K, Middlebrooks D, Guilkey K. A meta-analysis of the efficacy of anodal transcranial direct current stimulation for upper limb motor recovery in stroke survivors. J Hand Ther. 2013;26(2):162–71. https://doi.org/10.1016/j.jht.2012.07.002.

    Article  PubMed  Google Scholar 

  33. Elsner, B., Kugler, J., Pohl, M., & Mehrholz, J. (2013). Transcranial direct current stimulation (tDCS) for improving function and activities of daily living in patients after stroke. Cochrane Database of Syst Rev, (11), CD009645. https://doi.org/10.1002/14651858.CD009645.pub2.

  34. Gschwind M, Seeck M. Transcranial direct-current stimulation as treatment in epilepsy. Expert Rev Neurother. 2016;16(12):1427–41. https://doi.org/10.1080/14737175.2016.1209410.

    Article  CAS  PubMed  Google Scholar 

  35. Delnooz CCS, van de Warrenburg BPC. Current and future medical treatment in primary dystonia. Ther Adv Neurol Disord. 2012;5(4):221–40. https://doi.org/10.1177/1756285612447261.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. •• Ciechanski P, Kirton A. Transcranial direct-current stimulation can enhance motor learning in children. Cereb Cortex. 2017;27(5):2758–67. https://doi.org/10.1093/cercor/bhw114 This proof of principle study found that transcranial direct current stimulation (tDCS) can enhance motor learning, with lasting effects, in a typically developing pediatric population. These findings support the safety and potential therapeutic benefits of non-invasive neurostimulation in motor rehabilitation.

    Article  PubMed  Google Scholar 

  37. Oskoui M, Coutinho F, Dykeman J, Jetté N, Pringsheim T. An update on the prevalence of cerebral palsy: a systematic review and meta-analysis. Dev Med Child Neurol. n.d.;55(6):509–19. https://doi.org/10.1111/dmcn.12080.

  38. Baxter P, Morris C, Rosenbaum P, Paneth N, Leviton A, Goldstein M, et al. The definition and classification of cerebral palsy. Dev Med Child Neurol. 2007;49(s109):1–44.

    Google Scholar 

  39. Himmelmann K, Beckung E, Hagberg G, Uvebrant P. Gross and fine motor function and accompanying impairments in cerebral palsy. Dev Med Child Neurol. 2006;48(6):417–23. https://doi.org/10.1017/S0012162206000922.

    Article  CAS  PubMed  Google Scholar 

  40. Østensjø S, Carlberg EB, Vøllestad NK. Motor impairments in young children with cerebral palsy: relationship to gross motor function and everyday activities. Dev Med Child Neurol. 2004;46(9):580–9. https://doi.org/10.1111/j.1469-8749.2004.tb01021.x.

    Article  PubMed  Google Scholar 

  41. Willoughby KL, Dodd KJ, Shields N. A systematic review of the effectiveness of treadmill training for children with cerebral palsy. Disabil Rehabil. 2009;31(24):1971–9. https://doi.org/10.3109/09638280902874204.

    Article  PubMed  Google Scholar 

  42. Novak I, Mcintyre S, Morgan C, Campbell L, Dark L, Morton N, et al. A systematic review of interventions for children with cerebral palsy: state of the evidence. Dev Med Child Neurol. 2013;55(10):885–910. https://doi.org/10.1111/dmcn.12246.

    Article  PubMed  Google Scholar 

  43. Kuhnke N, Juenger H, Walther M, Berweck S, Mall V, Staudt M. Do patients with congenital hemiparesis and ipsilateral corticospinal projections respond differently to constraint-induced movement therapy? Dev Med Child Neurol. 2008;50(12):898–903. https://doi.org/10.1111/j.1469-8749.2008.03119.x.

    Article  CAS  PubMed  Google Scholar 

  44. Moura RCF, Santos C, Grecco LC, Albertini G, Cimolin V, Galli M, et al. Effects of a single session of transcranial direct current stimulation on upper limb movements in children with cerebral palsy: a randomized, sham-controlled study. Dev Neurorehabil. 2017;20(6):368–75. https://doi.org/10.1080/17518423.2017.1282050.

    Article  PubMed  Google Scholar 

  45. Viana RT, Laurentino GEC, Souza RJP, Fonseca JB, Silva Filho EM, Dias SN, et al. Effects of the addition of transcranial direct current stimulation to virtual reality therapy after stroke: a pilot randomized controlled trial. NeuroRehabilitation. 2014;34(3):437–46. https://doi.org/10.3233/NRE-141065.

    Article  CAS  PubMed  Google Scholar 

  46. Aree-uea B, Auvichayapat N, Janyacharoen T, Siritaratiwat W, DVM AA, Prasertnoo J, et al. Reduction of spasticity in cerebral palsy by anodal transcranial direct current stimulation. J Med Assoc Thail. 2014;97(9):9.

    Google Scholar 

  47. Kirton A, Ciechanski P, Zewdie E, Andersen J, Nettel-Aguirre A, Carlson H, et al. Transcranial direct current stimulation for children with perinatal stroke and hemiparesis. Neurology. 2017;88(3):259–67.

    Article  Google Scholar 

  48. Gillick B, Rich T, Nemanich S, Chen C-Y, Menk J, Mueller B, et al. Transcranial direct current stimulation and constraint-induced therapy in cerebral palsy: A randomized, blinded, sham-controlled clinical trial. Eur J Paediatr Neurol. 2018;22(3):358–68. https://doi.org/10.1016/j.ejpn.2018.02.001.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Minjoli S, Saturnino GB, Blicher JU, Stagg CJ, Siebner HR, Antunes A, et al. The impact of large structural brain changes in chronic stroke patients on the electric field caused by transcranial brain stimulation. NeuroImage: Clinical. 2017;15:106–17. https://doi.org/10.1016/j.nicl.2017.04.014.

    Article  Google Scholar 

  50. Moura, R. C. F., Santos, C. A., Grecco LAC, Lazzari RD, Dumont AJL, Duarte NC, Braun LA, …, Oliveira CS (2016). Transcranial direct current stimulation combined with upper limb functional training in children with spastic, hemiparetic cerebral palsy: study protocol for a randomized controlled trial. Trials, 17, 405. https://doi.org/10.1186/s13063-016-1534-7.

  51. Grecco LAC, Duarte NAC, Zanon, N, Galli M, Fregni F, Oliveira CS, … Oliveira CS (2014). Effect of a single session of transcranial direct-current stimulation on balance and spatiotemporal gait variables in children with cerebral palsy: a randomized sham-controlled study. Br J Physical Ther, 18(5), 419–427. https://doi.org/10.1590/bjpt-rbf.2014.0053.

  52. Ferreira SB, Rezende F, Dumont AJL, Ferreira LAB, Lazzari RD, Oliveira CS. Effect of a single session of transcranial direct current stimulation combined with virtual reality training on functional mobility in children with cerebral palsy: a randomized, controlled, double-blind trial. Manual Ther Posturol Rehabil J. 2014;12:202. https://doi.org/10.17784/mtprehabjournal.2014.12.202.

    Article  Google Scholar 

  53. Lazzari RD, Politti F, Santos CA, Dumont AJL, Rezende FL, Grecco LAC, et al. Effect of a single session of transcranial direct-current stimulation combined with virtual reality training on the balance of children with cerebral palsy: a randomized, controlled, double-blind trial. J Phys Ther Sci. 2015;27(3):763–8. https://doi.org/10.1589/jpts.27.763.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Grecco LAC, Duarte NDAC, Mendonça ME, Cimolin V, Galli M, Fregni F, et al. Transcranial direct current stimulation during treadmill training in children with cerebral palsy: a randomized controlled double-blind clinical trial. Res Dev Disabil. 2014;35(11):2840–8. https://doi.org/10.1016/j.ridd.2014.07.030.

    Article  PubMed  Google Scholar 

  55. Duarte N, De AC, Grecco LAC, Galli M, Fregni F, Oliveira CS. Effect of transcranial direct-current stimulation combined with treadmill training on balance and functional performance in children with cerebral palsy: a double-blind randomized controlled trial. PLoS One. 2014;9(8):e105777. https://doi.org/10.1371/journal.pone.0105777.

    Article  PubMed Central  Google Scholar 

  56. Collange Grecco LA, de Almeida Carvalho Duarte N, Mendonça ME, Galli M, Fregni F, Oliveira CS. Effects of anodal transcranial direct current stimulation combined with virtual reality for improving gait in children with spastic diparetic cerebral palsy: a pilot, randomized, controlled, double-blind, clinical trial. Clin Rehabil. 2015;29(12):1212–23. https://doi.org/10.1177/0269215514566997.

    Article  PubMed  Google Scholar 

  57. Lazzari RD, Politti F, Belina SF, Grecco LAC, Santos CA, Dumont AJL, … Oliveira CS (2017). Effect of transcranial direct current stimulation combined with virtual reality training on balance in children with cerebral palsy: a randomized, controlled, double-blind, clinical trial. J Mot Behav, 49(3), 329–336. doi:https://doi.org/10.1080/00222895.2016.1204266.

  58. de Almeida Carvalho Duarte N, Collange Grecco LA, Delasta Lazzari R, Pasini Neto H, Galli M, Santos Oliveira C. Effect of transcranial direct current stimulation of motor cortex in cerebral palsy: a study protocol. Pediatr Phys Ther. 2018;30(1):67–71. https://doi.org/10.1097/PEP.0000000000000467.

    Article  PubMed  Google Scholar 

  59. Grecco L, Duarte N, Marques V, Zanon N, Galli M, Fregni F, et al. Cerebellar transcranial direct current stimulation in a child with ataxic cerebral palsy: a case report. Gait Posture. 2015;42:S93–4. https://doi.org/10.1016/j.gaitpost.2015.06.171.

    Article  Google Scholar 

  60. Grecco LAC, Oliveira CS, Duarte N, De AC, Lima VLCC, Zanon N, et al. Cerebellar transcranial direct current stimulation in children with ataxic cerebral palsy: a sham-controlled, crossover, pilot study. Dev Neurorehabil. 2017;20(3):142–8. https://doi.org/10.3109/17518423.2016.1139639.

    Article  PubMed  Google Scholar 

  61. Grecco LAC, Oliveira CS, Galli M, Cosmo C, Duarte NDAC, Zanon N, et al. Spared primary motor cortex and the presence of MEP in cerebral palsy dictate the responsiveness to tDCS during gait training. Front Hum Neurosci. 2016;10:361.

    Article  Google Scholar 

  62. American Psychiatric Association (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.

  63. Cavanna AE, Seri S. Tourette’s syndrome. BMJ. 2013;347(aug20 2):f4964. https://doi.org/10.1136/bmj.f4964.

    Article  PubMed  Google Scholar 

  64. Kéri S, Szlobodnyik C, Benedek G, Janka Z, Gádoros J. Probabilistic classification learning in Tourette syndrome. Neuropsychologia. 2002;40(8):1356–62. https://doi.org/10.1016/S0028-3932(01)00210-X.

    Article  PubMed  Google Scholar 

  65. Marsh R, Alexander GM, Packard MG, Zhu H, Wingard JC, Quackenbush G, et al. Habit learning in Tourette syndrome: a translational neuroscience approach to a developmental psychopathology. Arch Gen Psychiatry. 2004;61(12):1259–68. https://doi.org/10.1001/archpsyc.61.12.1259.

    Article  PubMed  Google Scholar 

  66. Marsh R, Alexander GM, Packard MG, Zhu H, Peterson BS. Perceptual-motor skill learning in Gilles de la Tourette syndrome: evidence for multiple procedural learning and memory systems. Neuropsychologia. 2005;43(10):1456–65. https://doi.org/10.1016/j.neuropsychologia.2004.12.012.

    Article  PubMed  Google Scholar 

  67. Eddy CM, Rizzo R, Cavanna AE. Neuropsychological aspects of Tourette syndrome: a review. J Psychosom Res. 2009;67(6):503–13. https://doi.org/10.1016/j.jpsychores.2009.08.001.

    Article  PubMed  Google Scholar 

  68. McNaught KSP, Mink JW. Advances in understanding and treatment of Tourette syndrome. Nat Rev Neurol. 2011;7(12):667–76. https://doi.org/10.1038/nrneurol.2011.167.

    Article  CAS  PubMed  Google Scholar 

  69. Felling RJ, Singer HS. Neurobiology of Tourette syndrome: current status and need for further investigation. J Neurosci. 2011;31(35):12387–95. https://doi.org/10.1523/JNEUROSCI.0150-11.2011.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Eapen, V., Baker, R., Walter, A., Raghupathy, V., Wehrman, J. J., & Sowman, P. F. (2017). The Role of Transcranial Direct Current Stimulation (tDCS) in Tourette Syndrome: A Review and Preliminary Findings. Brain Sciences, 7(12):161. https://doi.org/10.3390/brainsci7120161.

  71. Carvalho S, Gonçalves ÓF, Soares JM, Sampaio A, Macedo F, Fregni F, et al. Sustained effects of a neural-based intervention in a refractory case of Tourette syndrome. Brain Stimul: Basic, Translational, and Clinical Research in Neuromodulation. 2015;8(3):657–9. https://doi.org/10.1016/j.brs.2014.12.008.

    Article  Google Scholar 

  72. Gowen E, Hamilton A. Motor abilities in autism: a review using a computational context. J Autism Dev Disord. 2013;43(2):323–44. https://doi.org/10.1007/s10803-012-1574-0.

    Article  PubMed  Google Scholar 

  73. de Moraes ÍAP, Massetti T, Crocetta TB, da Silva TD, de Menezes LDC, Monteiro CB, et al. Motor learning characterization in people with autism spectrum disorder: a systematic review. Dementia Neuropsychol. 2017;11(3):276–86. https://doi.org/10.1590/1980-57642016dn11-030010.

    Article  Google Scholar 

  74. Ecker C, Bookheimer SY, Murphy DGM. Neuroimaging in autism spectrum disorder: Brain structure and function across the lifespan. Lancet Neurol. 2015;14(11):1121–34. https://doi.org/10.1016/S1474-4422(15)00050-2.

    Article  PubMed  Google Scholar 

  75. Lang R, Koegel LK, Ashbaugh K, Regester A, Ence W, Smith W. Physical exercise and individuals with autism spectrum disorders: a systematic review. Res Autism Spectr Disord. 2010;4(4):565–76. https://doi.org/10.1016/j.rasd.2010.01.006.

    Article  Google Scholar 

  76. Bhat AN, Landa RJ, Galloway JCC. Current perspectives on motor functioning in infants, children, and adults with autism spectrum disorders. Phys Ther. 2011;91(7):1116–29. https://doi.org/10.2522/ptj.20100294.

    Article  Google Scholar 

  77. Bhat AN, Srinivasan S. A review of “music and movement” therapies for children with autism: embodied interventions for multisystem development. Front Integr Neurosci. 2013;7:22.

    PubMed  PubMed Central  Google Scholar 

  78. Amatachaya A, Auvichayapat N, Patjanasoontorn N, Suphakunpinyo C, Ngernyam N, Aree-uea B, et al. Effect of anodal transcranial direct current stimulation on autism: a randomized double-blind crossover trial. Behav Neurol. 2014;2014(173073):7. https://doi.org/10.1155/2014/173073.

    Article  Google Scholar 

  79. Amatachaya A, Jensen MP, Patjanasoontorn N, Auvichayapat N, Suphakunpinyo C, Janjarasjitt S, et al. The short-term effects of transcranial direct current stimulation on electroencephalography in children with autism: a randomized crossover controlled trial [Research article]. Behav Neurol. 2015;2015(928631):11. https://doi.org/10.1155/2015/928631.

    Article  Google Scholar 

  80. Philip RCM, Dauvermann MR, Whalley HC, Baynham K, Lawrie SM, Stanfield AC. A systematic review and meta-analysis of the fMRI investigation of autism spectrum disorders. Neurosci Biobehav Rev. 2012;36(2):901–42. https://doi.org/10.1016/j.neubiorev.2011.10.008.

    Article  PubMed  Google Scholar 

  81. Mosconi MW, Wang Z, Schmitt LM, Tsai P, Sweeney JA. The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders. Front Neurosci. 2015;9:296. https://doi.org/10.3389/fnins.2015.00296.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Hampson DR, Blatt GJ. Autism spectrum disorders and neuropathology of the cerebellum. Front Neurosci. 2015;9:420. https://doi.org/10.3389/fnins.2015.00420.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Kaiser M-L, Schoemaker MM, Albaret J-M, Geuze RH. What is the evidence of impaired motor skills and motor control among children with attention deficit hyperactivity disorder (ADHD)? Systematic review of the literature. Res Dev Disabil. 2015;36:338–57. https://doi.org/10.1016/j.ridd.2014.09.023.

    Article  Google Scholar 

  84. Fliers EA, Franke B, Lambregts-Rommelse NNJ, Altink ME, Buschgens CJM, Nijhuis-van der Sanden MWG, … Buitelaar JK (2009). Undertreatment of motor problems in children with ADHD. Child Adolesc Mental Health, 15(2), 85–90. doi:https://doi.org/10.1111/j.1475-3588.2009.00538.x.

  85. Rubia K, Alegria A, Brinson H. Imaging the ADHD brain: disorder-specificity, medication effects and clinical translation. Expert Rev Neurother. 2014;14(5):519–38. https://doi.org/10.1586/14737175.2014.907526.

    Article  CAS  PubMed  Google Scholar 

  86. Soltaninejad Z, Nejati V, & Ekhtiari H (2015). Effect of anodal and cathodal transcranial direct current stimulation on DLPFC on modulation of inhibitory control in ADHD. J Atten Disord, 1087054715618792. doi:https://doi.org/10.1177/1087054715618792.

  87. Breitling C, Zaehle T, Dannhauer M, Bonath B, Tegelbeckers J, Flechtner H-H, et al. Improving interference control in ADHD patients with transcranial direct current stimulation (tDCS). Front Cell Neurosci. 2016;10:72. https://doi.org/10.3389/fncel.2016.00072.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Bandeira ID, Guimarães RSQ, Jagersbacher JG, Barretto TL, de Jesus-Silva JR, Santos SN, et al. Transcranial direct current stimulation in children and adolescents with attention-deficit/hyperactivity disorder (ADHD): a pilot study. J Child Neurol. 2016;31(7):918–24. https://doi.org/10.1177/0883073816630083.

    Article  PubMed  Google Scholar 

  89. Nejati V, Salehinejad MA, Nitsche MA, Najian A, & Javadi A-H (2017). Transcranial direct current stimulation improves executive dysfunctions in ADHD: implications for inhibitory control, interference control, working memory, and cognitive flexibility. J Atten Disord, 1087054717730611. doi:https://doi.org/10.1177/108705471773061.

  90. Soff C, Sotnikova A, Christiansen H, Becker K, Siniatchkin M. Transcranial direct current stimulation improves clinical symptoms in adolescents with attention deficit hyperactivity disorder. J Neural Transm. 2017;124(1):133–44. https://doi.org/10.1007/s00702-016-1646-y.

    Article  PubMed  Google Scholar 

  91. Wilson PH, Ruddock S, Smits-Engelsman B, Polatajko H, Blank R. Understanding performance deficits in developmental coordination disorder: a meta-analysis of recent research. Dev Med Child Neurol. n.d.;55(3):217–28. https://doi.org/10.1111/j.1469-8749.2012.04436.x.

  92. Bo J, Lee C-M. Motor skill learning in children with developmental coordination disorder. Res Dev Disabil. 2013;34(6):2047–55. https://doi.org/10.1016/j.ridd.2013.03.012.

    Article  PubMed  Google Scholar 

  93. Blank R, Smits-Engelsman B, Polatajko H, Wilson P. European academy for childhood disability (EACD): recommendations on the definition, diagnosis and intervention of developmental coordination disorder (long version)*. Dev Med Child Neurol. n.d.;54(1):54–93. https://doi.org/10.1111/j.1469-8749.2011.04171.x.

  94. Smits-Engelsman BCM, Blank R, Kaay A-CVD, Meijs RM-VD, Brand EV-VD, Polatajko HJ, et al. Efficacy of interventions to improve motor performance in children with developmental coordination disorder: a combined systematic review and meta-analysis. Dev Med Child Neurol. n.d.;55(3):229–37. https://doi.org/10.1111/dmcn.12008.

  95. Biotteau M, Chaix Y, Blais M, Tallet J, Péran P, Albaret J-M. Neural signature of DCD: a critical review of MRI neuroimaging studies. Front Neurol. 2016;7:227. https://doi.org/10.3389/fneur.2016.00227.

    Article  PubMed  PubMed Central  Google Scholar 

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Grohs, M.N., Hilderley, A. & Kirton, A. The Therapeutic Potential of Non-invasive Neurostimulation for Motor Skill Learning in Children with Neurodevelopmental Disorders. Curr Dev Disord Rep 6, 19–28 (2019). https://doi.org/10.1007/s40474-019-0155-8

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