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Neurobiology of ADHD: A Review

  • ADHD (G Kulkarni, Section Editor)
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Abstract

Purpose of Review

ADHD is a complex neuropsychiatric condition which has been known to cause a lot of changes in the structural and functional aspects as well as neurochemistry of the brain.

Recent Findings

The structural aspects include changes primarily affecting but not limited to the prefrontal cortex, corpus striatum, and cerebellum. Dopamine and norepinephrine are the key neurotransmitters that are implicated in the pathophysiology of this condition. The above-mentioned neurotransmitter transporters and alterations or mutations to their genes have also been known to be a common finding in patients with ADHD.

Summary

This review article summarizes the intertwined relationship between different parts of the brain in patients with ADHD along with neurochemical and genetic basis of this disease. Larger studies should be conducted to have a better and definitive understanding of the pathophysiology of the disease.

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  1. Department of Neurology, University of Missouri, Columbia, USA

    Tejas R. Mehta, Yash Nene, Muniba Fayyaz & Pradeep C. Bollu

  2. Jacobs School of Medicine and Biomedical Science, Buffalo, NY, USA

    Alberto Monegro

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Mehta, T.R., Monegro, A., Nene, Y. et al. Neurobiology of ADHD: A Review. Curr Dev Disord Rep 6, 235–240 (2019). https://doi.org/10.1007/s40474-019-00182-w

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