The Concept of Atypical Brain Development in Developmental Coordination Disorder (DCD)—a New Look
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The concept of atypical brain development was introduced by Gilger and Kaplan in 2001 to describe developmental variation in brain functions and to account for the high degree of comorbidity among neurodevelopmental disorders. Developmental coordination disorder (DCD) is a common neurodevelopmental disorder affecting around 5–6 % of school-aged children. It is phenotypically heterogeneous, with up to 70 % of children meeting criteria for at least one other neurodevelopmental disorder. Recent genetic evidence has found that the same genes are implicated in various neurodevelopmental disorders, including DCD, attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder, and that these genes play a significant role in brain development. Imaging research has revealed that children with DCD display alterations in brain structure and function and that some of these alterations overlap with those that have been found children with ADHD, whereas others are unique to children who display DCD. Emerging genetic and imaging evidence supports the contention that DCD, which is associated with impairments in motor functioning, behavior, and other neuropsychological functions (e.g., visual perception, executive functioning), is due to atypical brain development. Future research is needed to help clarify the alterations in brain structure and function associated with this disorder and to examine etiological factors (e.g., genetics, teratogens, nutrition, very low birth weight) that place children at risk for DCD.
KeywordsAtypical brain development Developmental coordination disorder DCD Comorbidity Genetics Neuroimaging Brain structure Brain function
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Conflict of Interest
Deborah Dewey reports grants from Canadian Institutes of Health Research.
Francois P. Bernier declares that he has no conflict of interest.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
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- 1.American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th Edition (DSM-5). Diagnostic and statistical manual of mental disorders 4th edition TR. 2013.Google Scholar
- 8.••Blank R, Smiths-Engelsman B, Polatajko H, Wilson P. European Academy for Childhood Disability (EACD): recommendations on the definition, diagnosis and intervention of developmental coordination disorder (long version). Dev Med Child Neurol. 2012;54:54–93. This paper provides recommendations on the definition of developmental coordination disorder, diagnostic criteria, and appropriate interventions based on current research evidence.Google Scholar
- 11.Hill EL, Bishop DVM, Nimmo-Smith I. A dyspraxic deficit in specific language impairment and developmental coordination disorder? Evidence from hand and arm movements. Dev Med Child Neurol. 1998;17(6):388–95.Google Scholar
- 16.Capute AJ, Accardo PJ. A neurodevelopmental perspective on the continuum of developmental disabilities. In: Capute AJ, Accardo PJ, editors. Developmental disabilities in infancy and childhood. Baltimore: Paul H Brooks Publishing Co; 1991.Google Scholar
- 17.••Gilger JW, Kaplan BJ. Atypical brain development: a conceptual framework for understanding developmental learning disabilities. Dev Neuropsychol. 2001;20(2):465–81. This is the original article that introduced the concept of atypical brain development.Google Scholar
- 18.••Moreno-De-Luca A, Myers SM, Challman TD, Moreno-De-Luca D, Evans DW, Ledbetter DH. Developmental brain dysfunction: revival and expansion of old concepts based on new genetic evidence. Lancet Neurol. 2013;12(4):406–14. This paper discusses the concept of developmental brain dysfunction within the context of new genetic evidence. It presents the case that the high rates of comorbidity among neurodevelopmental disorders are due to genetic abnormalities, and that specific genetic causes, including certain copy number variants and single-gene mutations, are shared among disorders that are thought to be clinically distinct.Google Scholar
- 19.Statistics Canada. Table 2 Population estimates by sex and age group as of July 1, 2013, Canada [Internet]. 2013 [cited 2016 Jan 25]. Available from: http://www.statcan.gc.ca/daily-quoilable from: tidien/131125/t131125a002-eng.htm. 2013 .
- 23.Missiuna C, Moll S, King G, King S, Law M. “Missed and misunderstood”: children with coordination difficulties in the school system. Int J Spec Educ. 2006;21:53–67.Google Scholar
- 30.••Brown-Lum M, Zwicker J. Brian imaging increases our understanding of developmental coordination disorder: a review of literature and future directions. Curr Dev Disord Reports. 2015;2:131–40. This paper provides a recent review of the brain imaging literature on developmental coordination disorder.Google Scholar
- 31.••Langevin LM, Macmaster FP, Dewey D. Distinct patterns of cortical thinning in concurrent motor and attention disorders. Dev Med Child Neurol. 2015;57(3):257–64. This is the first structural imaging paper to examine cortical thickness in children with DCD only and DCD and co-occurring ADHD. It demonstrated that children with DCD only and DCD + ADHD displayed different patterns of cortical thinning. Children with DCD only displayed thinning in the temporal pole, whereas children with comorbid motor and attention problems displayed global thinning in the frontal, parietal, and temporal lobes.Google Scholar
- 32.•Langevin LM, Macmaster FP, Crawford S, Lebel C, Dewey D. Common white matter’ microstructure alterations in pediatric motor and attention disorders. J Pediatr. 2014;164(5). This is the first diffusion tensor imaging study to demonstrate that alterations in the corpus callosum are associated with difficulties in motor and attention functioning. Fractional anisotropy (FA) reductions were noted in the frontal regions of the corpus callosum for children with ADHD, whereas children with DCD displayed reductions in regions of the corpus callosum underlying parietal brain regions. Children with comorbid DCD and ADHD displayed FA reductions in both frontal and posterior regions of the corpus callosum.Google Scholar
- 33.•McLeod KR, Langevin LM, Goodyear BG, Dewey D. Functional connectivity of neural motor networks is disrupted in children with developmental coordination disorder and attention-deficit/hyperactivity disorder. NeuroImage Clin. 2014;4:566–75. This is the first paper to examine functional connectivity in the motor network in children with DCD, ADHD and co-occurring DCD + ADHD using resting state fMRI.Google Scholar
- 44.•Glessner JT, Connolly JJM, Hakonarson H. Rare genomic deletions and duplications and their role in neurodevelopmental disorders. Curr Top Behav Neurosci. 2012;12:345–60. This paper examines the role of CNV research in determining the etiology of developmental disorders such as attention deficit hyperactivity disorder and autism, and discusses relevant methodological considerations.Google Scholar
- 45.•Oskoui M, Gazzellone MJ, Thiruvahindrapuram B, et al. Clinically relevant copy number variations detected in cerebral palsy. Nat Commun. 2015;6:7949. This is the first paper to show that genes play an important role in cerebral palsy.Google Scholar
- 48.Thapar A, Martin J, Mick J, et al. Psychiatric gene discoveries shape evidence on ADHD’s biology. Mol Psychiatry. 2015;1–6.Google Scholar
- 49.••Bernier F, Mosca, Stephen J Langevin LM, Innes AM, Lionel, Anath C Marshall, Christian C Scherer, Stephen W Parboosingh, Jillian S Dewey D. Copy-number variation in Canadian children with developmental coordination disorder implicates neurodevelopmental genes. Journal of the International Neuropsychological Society : JINS. 2015. This is the first study to investigate copy number variation in children with DCD.Google Scholar
- 53.Shuvarikov A, Campbell I, Dittwald P, Neill N, Bialer M, Moore C, et al. Recurrent HERV-H-Mediated 3q13.2-q13.31 Deletions cause a syndrome of hypotonia and motor, language, and cognitive delays. Hum Mutat. 2013;1–31.Google Scholar
- 65.Kagerer F, Bo J, Contreras-Vidal JL, Clark JE. Visuomotor adaptation in children with developmental coordination disorder. Mot Control. 2004;8:450–60.Google Scholar
- 78.Peters LHJ, Maathuis CGB, Hadders-Algra M. Neural correlates of developmental coordination disorder. Dev Med Child Neurol. 2013;55(SUPPL.4):59–64. 80.Google Scholar