Current Behavioral Neuroscience Reports

, Volume 3, Issue 4, pp 275–284 | Cite as

Using Induced Pluripotent Stem Cells to Investigate Complex Genetic Psychiatric Disorders

  • Stephanie J. Temme
  • Brady J. Maher
  • Kimberly M. Christian
Genetics and Neuroscience (B Maher, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Genetics and Neuroscience

Abstract

Purpose of Review

Induced pluripotent stem cells (iPSCs) can be generated from human patient tissue samples, differentiated into any somatic cell type, and studied under controlled culture conditions. We review how iPSCs are used to investigate genetic factors and biological mechanisms underlying psychiatric disorders, and considerations for synthesizing data across studies.

Recent Findings

Results from patient specific-iPSC studies often reveal cellular phenotypes consistent with postmortem and brain imaging studies. Unpredicted findings illustrate the power of iPSCs as a discovery tool, but may also be attributable to limitations in modeling dynamic neural networks or difficulty in identifying the most affected neural subtype or developmental stage.

Summary

Technological advances in differentiation protocols and organoid generation will enhance our ability to model the salient pathology underlying psychiatric disorders using iPSCs. The field will also benefit from context-driven interpretations of iPSC studies that recognize all potential sources of variability, including differences in patient symptomatology, genetic risk factors, and affected cellular subtype.

Keywords

iPSCs Schizophrenia Bipolar disorder Autism spectrum disorders Psychiatric Cellular reprogramming 

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Stephanie J. Temme
    • 1
    • 2
    • 3
  • Brady J. Maher
    • 3
    • 4
    • 5
  • Kimberly M. Christian
    • 1
    • 2
  1. 1.Institute for Cell EngineeringJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of NeurologyJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Lieber Institute for Brain DevelopmentBaltimoreUSA
  4. 4.Department of Psychiatry and Behavioral SciencesJohns Hopkins University School of MedicineBaltimoreUSA
  5. 5.Department of NeuroscienceJohns Hopkins University School of MedicineBaltimoreUSA

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