Current Behavioral Neuroscience Reports

, Volume 3, Issue 3, pp 218–231

The Genetics of Gilles de la Tourette Syndrome: a Common Aetiological Basis with Comorbid Disorders?

  • Iordanis Karagiannidis
  • Fotis Tsetsos
  • Shanmukha Sampath Padmanabhuni
  • John Alexander
  • Marianthi Georgitsi
  • Peristera Paschou
Child and Developmental Psychiatry (M Grados, Section Editor)

DOI: 10.1007/s40473-016-0088-z

Cite this article as:
Karagiannidis, I., Tsetsos, F., Padmanabhuni, S.S. et al. Curr Behav Neurosci Rep (2016) 3: 218. doi:10.1007/s40473-016-0088-z
Part of the following topical collections:
  1. Topical Collection on Child and Developmental Psychiatry

Abstract

Purpose of Review

Gilles de la Tourette syndrome (TS) is a childhood-onset neurodevelopmental disorder characterized by multiple motor and vocal tics, commonly associated with attention deficit hyperactivity disorder (ADHD), obsessive–compulsive disorder (OCD) and autism spectrum disorders (ASDs). Here, we summarize and discuss evidence pointing to a shared genetic basis among TS, OCD, ADHD and ASD.

Recent Findings

TS has a complex genetic aetiology, with many genes interacting with each other and with environmental factors in order to lead to the onset of symptoms. Only 10–13.5 % of cases can be referred to as pure TS (i.e. tics only); the vast majority of patients present with psychiatric comorbidities (ADHD, OCD, ASD). We review evidence that supports the hypothesis of a shared aetiological background across neurodevelopmental phenotypes.

Summary

This review highlights the importance of thinking across diagnostic categories when attempting to understand the neurobiology of neurodevelopmental phenotypes. Analysing across a spectrum of intermediate phenotypes rather than on ends of a distribution may hold the promise to unravel the aetiology of TS and other neurodevelopmental disorders.

Keywords

Gilles de la Tourette syndrome Genetics Autism spectrum disorders Attention deficit hyperactivity disorder ADHD Obsessive–compulsive disorder OCD Cross-disorder analysis 

Funding information

Funder NameGrant NumberFunding Note
Seventh Framework Programme
  • 316978

Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Iordanis Karagiannidis
    • 1
  • Fotis Tsetsos
    • 1
  • Shanmukha Sampath Padmanabhuni
    • 1
  • John Alexander
    • 1
  • Marianthi Georgitsi
    • 1
    • 2
  • Peristera Paschou
    • 1
  1. 1.Department of Molecular Biology and GeneticsDemocritus University of Thrace, PanepistimioupoliAlexandroupoliGreece
  2. 2.Department of MedicineAristotle University of ThessalonikiThessalonikiGreece

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