Personalizing the Treatment of Pediatric Obsessive-Compulsive Disorder: Evidence for Predictors and Moderators of Treatment Outcomes
Cognitive behavioral therapy (CBT), delivered alone or with a serotonin reuptake inhibitor (SRI), is efficacious for treating pediatric obsessive-compulsive disorder (OCD), but not all youth respond optimally. Research to understand for whom a given intervention is beneficial can inform efforts to personalize treatment or tailor it to specific youths to enhance outcomes. We review studies that examined potential predictors/moderators of response to CBT, medication, and multimodal treatment for pediatric OCD: demographics, disorder-specific characteristics, general illness characteristics, neuropsychological functioning, biomarkers, family factors, and non-specific therapy factors. Methodological differences across studies make it challenging to synthesize findings and more research with large samples is needed. However, family factors have emerged as relatively consistent and strong predictors of treatment outcomes and there is preliminary support for attention to the presence of tics in treatment selection. There is little evidence for age and other demographic differences in treatment response.
KeywordsObsessive-compulsive disorder Treatment Predictors Moderators Children
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Conflict of Interest
Dr. Caporino declares that she has no conflict of interest.
Dr. Storch reports grants from NIH; grants from AHRQ; personal fees from Wiley, American Psychological Association, Elsevier, Lawrence Erlbaum, and Springer; personal fees from Prophase, Inc.; personal fees from Rogers Memorial Hospital; and non-financial support and other from IOCDF, outside the submitted work.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
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