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Adverse Cardiovascular Events in Post-Renal Transplant Patients, a Retrospective Study of Five Hundred Cases Over Twenty-Two Years

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Abstract

Background

Renal transplant recipients (RTRs) remain at an increased risk of fatal and non-fatal cardiovascular (CV) events compared to the general population. Death is most commonly due to cardiovascular diseases.

Purpose

The primary outcome of this work is the determination of adverse CV events and their risk factors in the RTR population and their effect on mortality.

Methods

A retrospective analysis has been performed on data from 500 patients at the Cairo Kidney Center, Cairo, Egypt, who underwent kidney transplantation with a graft from a living donor. Data was collected for RTR starting from 1992 till 2014.

Results

The mean age of patients was 41.90 ± 9.67 years. 63.8% of them were males. CV complications (stable angina pectoris, acute coronary syndrome, new left ventricular hypertrophy (LVH), positive myocardial perfusion scan, elevated cardiac enzymes, and invasive coronary angiography) occurred in (22.6%, 2.4%, 49.8%, 13.6%, 1.8%, and 7.6%) of patients, respectively. Other CV complications occurred in (24.0%, 11.2%, and 40.8%), including Congestive Heart Failure (CHF), cardiomyopathy, and arrhythmias.The main causes of mortality were CV diseases, infections, cancer, surgical complications, and liver disease (19.0%, 13.4%, 1.6%, 1.4%, and 1.2%), respectively.

Conclusion

RTR are at an extremely high risk of adverse CV events. CV complications (CHF, ischemic heart diseases, LVH, and arrhythmias) are the leading causes of death in RTR.

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Acknowledgements

We are grateful for the word clerk team who present a lot of help in bringing and collecting all data from the filing system and old files.

Funding

No funds, grants, or other support was received.

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Authors and Affiliations

  1. Critical Care Department, Cairo University, Cairo, Egypt

    Mohamed Soliman, Hassan Effat & Tarek Elgohary

  2. Critical Care Department Mataria Teaching Hospitals, Cairo, Egypt

    Amir Eskander

  3. Internal Medicine Department, Cairo University, Cairo, Egypt

    Tarek Fayad

Authors
  1. Mohamed Soliman
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  2. Amir Eskander
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  3. Hassan Effat
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  4. Tarek Fayad
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  5. Tarek Elgohary
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Correspondence to Mohamed Soliman.

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Soliman, M., Eskander, A., Effat, H. et al. Adverse Cardiovascular Events in Post-Renal Transplant Patients, a Retrospective Study of Five Hundred Cases Over Twenty-Two Years. Curr Transpl Rep 10, 89–99 (2023). https://doi.org/10.1007/s40472-023-00399-0

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