Skip to main content

Advertisement

Log in

Intraoperative Management of the Kidney Transplant Recipient

  • Kidney Transplantation (M Henry, Section Editor)
  • Published:
Current Transplantation Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

The purpose of this study was to review current literature on the intraoperative management of the kidney transplant recipient in terms of preoperative evaluation, anesthetic agents of choice, monitoring needs, intraoperative fluid and hemodynamic management, and perioperative pain control options.

Recent Findings

More recent literature regarding intraoperative kidney management suggests less aggressive volume loading with a balanced crystalloid solution, particularly in regard to albumin and blood products, with increased consideration for multimodal therapies for nausea and pain control.

Summary

Perioperative kidney management is crucial to immediate- and long-term outcomes for graft and patient survival. Surgical and anesthetic techniques should continue to be honed to allow for ideal renal perfusion intraoperatively. Considerations for intraoperative optimization for renal transplantation include the appropriate types and volume of fluid based on cardiac risk factors with the increasing number of elderly recipients, the avoidance of vasoconstrictive agents, and a reduction in perioperative cardiac-depressing agents for pain that may be managed by multimodal therapies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LY, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med. 1999;341:1725–30.

    Article  CAS  PubMed  Google Scholar 

  2. Rabbat CG, Thorpe KE, Russell JD, Churchill DN. Comparison of mortality risk of dialysis patients and cadaveric first renal transplant recipients in Ontario, Canada. J Am Soc Nephrol. 2000;11:917–22.

    CAS  PubMed  Google Scholar 

  3. Ogutmen B, Yildrim A, Sever MS, Bozfakioglu S, Ataman R, Erek E, et al. Health-related quality of life after kidney transplantation in comparison intermittent hemodialysis, peritoneal dialysis, and normal controls. Transplant Proc. 2006;38:419–21.

    Article  CAS  PubMed  Google Scholar 

  4. Eggers P. Comparison of treatment costs between dialysis and transplantation. Semin Nephrol. 1992;12:284–9.

    CAS  PubMed  Google Scholar 

  5. Hartmann EL, Wu C. The evolving challenge of evaluating older renal transplant candidates. Adv Chronic Kidney Dis. 2010;17(4):358–67.

    Article  PubMed  Google Scholar 

  6. Tapiawala SN, Tinckam KJ, Cardella CJ, Schiff J, Cattran DC, Cole EH, et al. Delayed graft function and the risk for death with a functioning graft. J Am Soc Nephrol. 2010;21:153–61.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Stockall C, et al. Renal transplantation. In: Sharpe MD, Gelb AW, editors. Anesthesia and transplantation. Boston: Butterworth and Heinemann; 1999. p. 241.

    Google Scholar 

  8. Cosio FG, Alamir A, Yim S, Pesavento TE, Falkenhain ME, Henry ML, et al. Patient survival after renal transplantation: I. The impact of dialysis pre-transplant. Kidney Intl. 1998;53:767–72.

    Article  CAS  Google Scholar 

  9. Ojo AO, Hanson JA, Wolfe RA, Leichtman AB, Agodoa LY, Port FK. Long-term survival in renal transplant recipients with graft function. Kidney Int. 2000;57:307–13.

    Article  CAS  PubMed  Google Scholar 

  10. Hart A, Weir MR, Kasiske BL. Cardiovascular risk assessment in kidney transplantation. Kidney Int. 2015;87:527–34.

    Article  PubMed  Google Scholar 

  11. Boden WE, O’Rourke RA, Teo KK, Hartigan PM, Maron DJ, Kostuk WJ, et al. Optimal medical therapy with or without PCI for stable coronary disease. N Engl J Med. 2007;356:1503–16.

    Article  CAS  PubMed  Google Scholar 

  12. McFalls EO, Ward HB, Moritz TE, Goldman S, Krupski WC, Littooy F, et al. Coronary-artery revascularization before elective major vascular surgery. N Engl J Med. 2004;351:2795–804.

    Article  CAS  PubMed  Google Scholar 

  13. Rabbat CG, Treleaven DJ, Russell JD, Ludwin D, Cook DJ. Prognostic value of myocardial perfusion studies in patients with end-stage renal disease assessed for kidney or kidney-pancreas transplantation: a meta-analysis. J Am Soc Nephrol. 2003;14:431–9.

    Article  PubMed  Google Scholar 

  14. Gill JS, Ma I, Landsberg D, Johnson N, Levin A. Cardiovascular events and investigation in patients who are awaiting cadaveric kidney transplantation. J Am Soc Nephrol. 2005;16:808–16.

    Article  PubMed  Google Scholar 

  15. De Lima JJ, Sabbaga E, Vieira ML, de Paula FJ, Ianhez LE, Krieger EM, et al. Coronary angiography is the best predictor of events in renal transplant candidates compared with noninvasive testing. Hypertension. 2003;42:263–8.

    Article  CAS  PubMed  Google Scholar 

  16. Manske CL, Wang W, Rector T, Wilson RF, White CW. Coronary revascularisation in insulin-dependent diabetic patients with chronic renal failure. Lancet. 1992;340:998–1002.

    Article  CAS  PubMed  Google Scholar 

  17. Hennessy TG, Codd MB, Kane G, McCarthy C, McCann HA, Sugrue DD. Evaluation of patients with diabetes mellitus for coronary artery disease using dobutamine stress echocardiography. Coron Artery Dis. 1997;8:171–4.

    Article  CAS  PubMed  Google Scholar 

  18. Herzog CA, Marwick TH, Pheley AM, White CW, Rao VK, Dick CD. Dobutamine stress echocardiography for the detection of significant coronary artery disease in renal transplant candidates. Am J Kidney Dis. 1999;33:1080–90.

    Article  CAS  PubMed  Google Scholar 

  19. Humar A, Kerr SR, Ramcharan T, Gillingham KJ, Matas AJ. Peri-operative cardiac morbidity in kidney transplant recipients: incidence and risk factors. Clin Transpl. 2001;15:154–8.

    Article  CAS  Google Scholar 

  20. Lemmens HJ. Kidney transplantation: recent developments and recommendations for anesthetic management. Anesthesiol Clin North Am. 2004;22:651–62.

    Article  Google Scholar 

  21. Fleisher LA, Fleischmann KE, Auerbach AD, Barnason SA, Beck JA, Bozkurt B, et al. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: executive summary: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation. 2014;64:e77–137.

    Google Scholar 

  22. Ricaurte L, Vargas J, Lozan E, Diaz L. Anesthesia and kidney transplantation. Transplant Proc. 2013;45:1386–91.

    Article  CAS  PubMed  Google Scholar 

  23. Kwon S, Thompson R, Dellinger P, Yanez D, Farrohki E, Flum D. Importance of perioperative glycemic control in general surgery: a report from the surgical care and outcomes assessment program. Ann Surg. 2013;257:8–14.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Buvanendran A, Kroin JS. Multimodal analgesia for controlling acute postoperative pain. Curr Opin Anesthesiology. 2009;22:588–93.

    Article  Google Scholar 

  25. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Am J Health-Syst Pharm 2013: 70: 195–283

  26. Heylen L, Naesens M, Jochmans I, Monbaliu D, Lerut E, Claes K, et al. The effect of anastomosis time on outcome in recipients of kidneys donated after brain death: a cohort study. Am J Transplantation. 2015;15:2900–7.

    Article  CAS  Google Scholar 

  27. American Society of Anesthesiologists. Standards for basic anesthetic monitoring. www.asahq.org/Search.aspx?q=standards+basic+anesthetic+monitoring. Accessed December 21, 2016.

  28. Spiro M, Eilers H. Intraoperative care of the transplant patient. Anesthesiology Clin. 2013;31:705–21.

    Article  Google Scholar 

  29. Lemmens HJ. Anesthesia for renal transplantation. https://www.uptodate.com/contents/anesthesia-for-renal-transplantation. Accessed December 21, 2016.

  30. Murakami M, Nomiyama S, Ozawa A, Matano H, Tanabe Y, Watanabe S. Anesthetic management of pediatric renal transplantation for chronic renal failure. Masui. 1993;42:263–70.

    CAS  PubMed  Google Scholar 

  31. Ikeda K, Maoka H, Yoshimatsu N, Sugi M, Tokutsu K, Isshiki A. Hemodynamic changes secondary to overload infusion during cadaveric renal transplantation comparison between nitrous oxide-isoflurane anesthesia and continuous epidural anesthesia. Masui. 1993;42:835–9.

    CAS  PubMed  Google Scholar 

  32. Akpek E, Kayhan Z, Kaya H, Candan S, Haberal M Epidural anesthesia for renal transplantation: a preliminary report. Transplant Proc. 1999;31:3149-50.

  33. Hadimioglu N, Ertug Z, Bigat Z, Yilmaz M, Yegin A. A randomized study comparing combined spinal epidural or general anesthesia for renal transplant surgery. Transplant Proc. 2005;37:2020–2.

    Article  CAS  PubMed  Google Scholar 

  34. Kirvela M, Olkkola KT, Rosenberg PH, Yli-Hankala A, Salmela K, Lindgren L. Pharmacokinetics of propofol and haemodynamic changes during induction of anaesthesia in uraemic patients. Br J Anaesth. 1992;68:178–82.

    Article  CAS  PubMed  Google Scholar 

  35. Ma H, Zhuang X. Selection of neuromuscular blocking agents in patients undergoing renal transplantation under general anesthesia. Chin Med J. 2002;115:1692–6.

    PubMed  Google Scholar 

  36. Dawidson I, Ar’Rajab A, Dickerman R, Husberg B, Klintmalm G, Lu C, et al. Perioperative albumin and verapamil improve early outcome after cadaver renal transplantation. Transplant Proc. 1994;26:3100–1.

    CAS  PubMed  Google Scholar 

  37. Wilms CD, Daawidson IJ, Dickerman R, Drake D, Sandor ZF, Trevino G. Intraoperative blood volume expansion induced primary function after renal transplantation: a study of 96 paired cadaver kidneys. Transplant Proc. 1991;223:1338–9.

    Google Scholar 

  38. Luciani J, Frantz P, Thibault P, Ghesquierre F, Conseiller C, Cousin MT, et al. Early anuria prevention in human kidney transplantation. Advanatage of fluid load under pulmonary arterial pressure monitoring duinr surgical period. Transplantation. 1979;28:308–212.

    Article  CAS  PubMed  Google Scholar 

  39. • Carlier M, Squifflet JP, Pirson Y, Girbomont B, Alexandre GP. Maximal hydration during anesthesia increased pulmonary arterial pressures and improves early function in human renal transplants. Transplantation. 1982;34:201–4. Landmark study using PAPs to assess the outcomes of aggressive volume loading in renal transplant recipients which showed significant reductions in ATN with increased pressures.

    Article  CAS  PubMed  Google Scholar 

  40. Othman MM, Ismael AZ, Hammouda GE. The impact of timing of maximal crystalloid hydration on early graft function during kidney transplantation. Anesth Analg. 2010;110:1440–6.

    Article  PubMed  Google Scholar 

  41. • De Gasperi A, Narcisi S, Mazza E, Bettinelli L, Pavani M, Perrone L, et al. Perioperative fluid management in kidney transplantation: is volume overload still mandatory for graft function? Transplant Proc. 2006;38:807–9. Evaluated more conservative volume repletion with a CVP goal of 7–9 mmHg with similar outcomes to supranormal levels of hydration.

    Article  CAS  PubMed  Google Scholar 

  42. O’Malley CM, Frumento RJ, Bennett-Guerrero E. Intravenous fluid therapy in renal transplant recipients: results of a US survey. Transplant Proc. 2012;34:3142–5.

    Article  Google Scholar 

  43. O’Malley CM, Frumento RJ, Hardy MA, Benvenisty AI, Brentjens TE, Mercer JS, et al. A randomized, double-blind comparison of lactated Ringer’s solution and 0.9% NaCl during renal transplantation. Anesth Analg. 2005;100:1518–24.

    Article  PubMed  Google Scholar 

  44. Potura E, Lindner G, Biesenback P, Funk GC, Reiterer C, Kabon B, et al. An acetate-buffered balanced crystalloid versus 0.9% saline in patients with end-stage renal disease undergoing cadaveric renal transplantation: a prospective randomized controlled trial. Anesth Analg. 2015;120:123–9.

    Article  CAS  PubMed  Google Scholar 

  45. • Hadimioglu N, Saadawy I, Saglam T, Ertug Z, Dinckan A. The effect of different crystalloid solutions on acid-base balance and early kidney function after kidney transplantation. Anesth Analg. 2008;107:264–9. Best metabolic parameters are obtained post-renal transplantation using Plasmalyte vs. normal saline or lactated Ringer’s solution.

    Article  CAS  PubMed  Google Scholar 

  46. Dawidson IJ, Sandor ZF, Coorpender L, Palmer B, Peters P, Lu C, et al. Intraoperative albumin administration affects the outcomes of cadaver renal transplantation. Transplantation. 1992;53:774–82.

    Article  CAS  PubMed  Google Scholar 

  47. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350:2247–56.

    Article  CAS  PubMed  Google Scholar 

  48. Wilkes MM, Navickis RJ. Patient survival after human albumin administration. A meta-analysis of randomized, controlled trials. Ann Intern Med. 2001;135:149–64.

    Article  CAS  PubMed  Google Scholar 

  49. Opperer M, Poeran J, Rasul R, Mazudmar M, Memtsoudis SG. Use of perioperative hydroxyethyl starch 6% and albumin 5% in elective joint arthroplasty and association with adverse outcomes: a retrospective population based analysis. BMJ. 2015;350:h1567–74.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Hebert PC, Wells G, Blajchman MA, Marshall J, Martin C, Paglierro G, et al. A multicenter, randomized, controlled clinical trial of transfusion requirement in critical care. N Engl J Med. 1999;340:409–17.

    Article  CAS  PubMed  Google Scholar 

  51. Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy MM, Abraham E, et al. The CRIT study: anemia and blood transfusion in the critically ill—current clinic practice in the United States. Crit Care Med. 2004;32:39–52.

    Article  PubMed  Google Scholar 

  52. Tiggeler RG, Berden JH, Hoitsma AJ, Koene RA. Prevention of acute tubular necrosis in cadaveric kidney transplantation by the combine use of mannitol and moderate hydration. Ann Surg. 1985;20:246–51.

    Article  Google Scholar 

  53. Hanif F, Macrae AN, Littlejohn MG, Clancy MJ, Murio E. Outcomes of renal transplantation with and without intra-operative diuretics. Int J Surg. 2011;9:460–3.

    Article  CAS  PubMed  Google Scholar 

  54. Gabriels G, August C, Grisk O, Steinmetz M, Kosch M, Rahn KH, et al. Impact of renal transplantation on small vessel reactivity. Transplantation. 2003;75:698–7.

    Google Scholar 

  55. • Ciapetti M, di Valvasone S, di Filippo A, Cecchi A, Bonizzoli M, Peris A. Low-dose dopamine in kidney transplantation. Transplantation Proc. 2009;41:4165–8. Study that showed renally dosed dopamine for renal blood flow effects was associated with worse outcomes including 6-month mortality.

    Article  CAS  Google Scholar 

  56. Bulka CM, Terkhov MA, Martin BJ, Dmochowski RR, Hayes RB, Ehrenfeld JM. Nondepolarizing neuromuscular blocking agents, reversal and risk of postoperative pneumonia. Anesthesiology. 2016;125:647–55.

    Article  CAS  PubMed  Google Scholar 

  57. Nagar VR, Birthi P. Chronic opioid management for chronic kidney disease. J Pain Palliat Care Pharmac. 2015;29:45–50.

    Google Scholar 

  58. Mohammadi S, Dabir A, Shoeibi G. Efficacy of transversus abdominis plane block for acute postoperative pain relief in kidney recipients: a double-blinded clinical trial. Pain Med. 2014;15:460–4.

    Article  Google Scholar 

  59. Kuruba G, Mukhtar K, Singh SK. A randomised controlled trial of ultrasound-guided transversus abdominis plane block for renal transplantation. Anaesthesia. 2014;69:1222–6.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rachel C. Forbes.

Ethics declarations

Conflict of Interest

Rachel Forbes, Adam King, and Beatrice Concepcion declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Kidney Transplantation

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Forbes, R.C., Concepcion, B.P. & King, A.B. Intraoperative Management of the Kidney Transplant Recipient. Curr Transpl Rep 4, 75–81 (2017). https://doi.org/10.1007/s40472-017-0142-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40472-017-0142-0

Keywords

Navigation