High-precision microfluidic pressure control through modulation of dual fluidic resistances


This work presents an approach to the modulation of dual fluidic resistances for long-term, high-speed, and high precision (less than 0.5% steady-state error) control of the inlet pressure of a microfluidic device. This is accomplished through independent controls of dual variable resistances in a fluid network between a pressurized reservoir and a microfluidic device. We show the superior characteristics of the system with dual resistance modulation by experimentally comparing our new model with our previous approach. We demonstrate the performance of the controlled system and address the long-term stability and robustness. This system can be utilized in a variety of applications that require high-precision, high-speed, and long-term controls of microfluidic flows, including chemical synthesis, cell sorting, energy harvesting optofluidics, microbial fuel cells, and multiscale biological investigation of cellular or tissue level.

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This work was supported by the startup resources of Georgia Institute of Technology (Y.K.) and by the National Science Foundation under CAREER CMMI 1653006 (Y.K.).

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Correspondence to YongTae Kim.

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Toth, M.J., Kawahara, T. & Kim, Y. High-precision microfluidic pressure control through modulation of dual fluidic resistances. Int. J. Dynam. Control 6, 1175–1182 (2018). https://doi.org/10.1007/s40435-017-0378-7

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  • Pressure control
  • Fluidic resistance
  • Nonlinear
  • Feedback control
  • Microfluidics