Skip to main content

Advertisement

SpringerLink
Log in

Neurocircuitry of Mindfulness-Based Interventions for Substance Use Prevention and Recovery

  • Neuroscience & Addiction (A Haghparast and H Ekhtiari, Section Editor)
  • Published:
Current Addiction Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

Substance use disorders (SUD) are chronic and disabling conditions associated with significant public health burden. Current evidence-based treatments, while effective, have limited success and result in high relapse rates. Interventions that directly target the neurobiological mechanisms of addiction may be better poised to improve outcomes in this population. By promoting awareness of internal and external experiences, mindfulness training (MT) increases self-regulation and flexibility in behaviors and may effectively target the neural mechanisms implicated in SUD. This article examines the current literature of neurocircuitry of MT in SUD.

Recent Findings

Few studies have used neuroscientific methods to understand the effect of MT on neurocircuitry linked to SUD. Furthermore, neuroscientific MT studies have primarily focused on cigarette smoking behaviors. Nevertheless, MT may be effective in reducing substance use by targeting neurocircuitry involved in reward, stress, and attention processes.

Summary

Our current understanding of neurocircuitry underlying MT for SUD recovery and relapse prevention is limited. Future experimental research is needed to delineate the effect of MT across stages of SUD, including intoxication, withdrawal, and craving.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. U.S. Department of Health and Human Services SAaMHSA, Center for Behavioral Health Statistics and Quality. National survey on drug use and health 2019. 2019.

  2. Health UDo, Services H. The health consequences of smoking—50 years of progress: a report of the Surgeon General. Atlanta, GA: US Department of Health and Human Services, Centers for Disease …; 2014.

  3. Xu X, Bishop EE, Kennedy SM, Simpson SA, Pechacek TF. Annual healthcare spending attributable to cigarette smoking: an update. Am J Prev Med. 2015;48(3):326–33.

    Article  PubMed  Google Scholar 

  4. Control CfD, Prevention. Excessive drinking is draining the US economy. Centers for Disease Control and Prevention. 2016.

  5. US Dept of Justice NDIC, America USo. National Drug Threat Assessment 2010. 2010.

  6. Birnbaum HG, White AG, Schiller M, Waldman T, Cleveland JM, Roland CL. Societal costs of prescription opioid abuse, dependence, and misuse in the United States. Pain Med. 2011;12(4):657–67.

    Article  PubMed  Google Scholar 

  7. Florence C, Luo F, Xu L, Zhou C. The economic burden of prescription opioid overdose, abuse and dependence in the United States, 2013. Med Care. 2016;54(10):901.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Jhanjee S. Evidence based psychosocial interventions in substance use. Indian J Psychol Med. 2014;36(2):112–8.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Ii T, Sato H, Watanabe N, Kondo M, Masuda A, Hayes SC, et al. Psychological flexibility-based interventions versus first-line psychosocial interventions for substance use disorders: systematic review and meta-analyses of randomized controlled trials. J Contextual Behav Sci. 2019;13:109–20.

    Article  Google Scholar 

  10. Dutra L, Stathopoulou G, Basden SL, Leyro TM, Powers MB, Otto MW. A meta-analytic review of psychosocial interventions for substance use disorders. Am J Psychiatry. 2008;165(2):179–87.

    Article  PubMed  Google Scholar 

  11. Brecht M-L, Herbeck D. Time to relapse following treatment for methamphetamine use: a long-term perspective on patterns and predictors. Drug Alcohol Depend. 2014;139:18–25.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Lee JD, Nunes EV Jr, Novo P, Bachrach K, Bailey GL, Bhatt S, et al. Comparative effectiveness of extended-release naltrexone versus buprenorphine-naloxone for opioid relapse prevention (X: BOT): a multicentre, open-label, randomised controlled trial. The Lancet. 2018;391(10118):309–18.

    Article  CAS  Google Scholar 

  13. Luoma JB. Substance use stigma as a barrier to treatment and recovery. Addiction medicine: Springer; 2010. p. 1195-215.

  14. Rapp RC, Xu J, Carr CA, Lane DT, Wang J, Carlson R. Treatment barriers identified by substance abusers assessed at a centralized intake unit. J Subst Abuse Treat. 2006;30(3):227–35.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Garland E, Froeliger B, Howard M. Mindfulness training targets neurocognitive mechanisms of addiction at the attention-appraisal-emotion interface. Front Psych. 2014;4:173.

    Google Scholar 

  16. Garland EL, Howard MO. Mindfulness-based treatment of addiction: current state of the field and envisioning the next wave of research. Addict Sci Clin Pract. 2018;13(1):1–14.

    Article  Google Scholar 

  17. Houlihan SD, Brewer JA. The emerging science of mindfulness as a treatment for addiction. Mindfulness and Buddhist-derived approaches in mental health and addiction: Springer; 2016. p. 191–210.

  18. Koob GF, Volkow ND. Neurobiology of addiction: a neurocircuitry analysis. The Lancet Psychiatry. 2016;3(8):760–73.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Shapiro SL, Carlson LE, Astin JA, Freedman B. Mechanisms of mindfulness. J Clin Psychol. 2006;62(3):373–86.

    Article  PubMed  Google Scholar 

  20. Creswell JD. Mindfulness interventions. Annu Rev Psychol. 2017;68:491–516.

    Article  PubMed  Google Scholar 

  21. Zenner C, Herrnleben-Kurz S, Walach H. Mindfulness-based interventions in schools—a systematic review and meta-analysis. Front Psychol. 2014;5.

  22. Borquist-Conlon DS, Maynard BR, Brendel KE, Farina AS. Mindfulness-based interventions for youth with anxiety: a systematic review and meta-analysis. Res Soc Work Pract. 2017;1049731516684961.

  23. Zack S, Saekow J, Kelly M, Radke A. Mindfulness based interventions for youth. J Rational-Emot Cognitive-Behav Ther. 2014;32(1):44–56.

    Article  Google Scholar 

  24. Davis DM, Hayes JA. What are the benefits of mindfulness? A practice review of psychotherapy-related research. Psychotherapy. 2011;48(2):198.

    Article  PubMed  Google Scholar 

  25. Ortiz R, Sibinga EM. The role of mindfulness in reducing the adverse effects of childhood stress and trauma. Children. 2017;4(3):16.

    Article  PubMed Central  Google Scholar 

  26. Biegel GM, Chang K, Garrett A, Edwards M. Mindfulness-based stress reduction for teens. Mindfulness-based treatment approaches: Elsevier; 2014. p. 189-212.

  27. Khoury B, Lecomte T, Fortin G, Masse M, Therien P, Bouchard V, et al. Mindfulness-based therapy: a comprehensive meta-analysis. Clin Psychol Rev. 2013;33(6):763–71.

    Article  PubMed  Google Scholar 

  28. Grant S, Colaiaco B, Motala A, Shanman R, Booth M, Sorbero M, et al. Mindfulness-based relapse prevention for substance use disorders: a systematic review and meta-analysis. J Addict Med. 2017;11(5):386.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Sancho M, De Gracia M, Rodriguez RC, Mallorquí-Bagué N, Sánchez-González J, Trujols J, et al. Mindfulness-based interventions for the treatment of substance and behavioral addictions: a systematic review. Front Psych. 2018;9:95.

    Article  Google Scholar 

  30. Bowen S, Chawla N, Witkiewitz K. Mindfulness-based relapse prevention for addictive behaviors. Mindfulness-based treatment approaches: Elsevier; 2014. p. 141-57.

  31. Garland EL, Manusov EG, Froeliger B, Kelly A, Williams JM, Howard MO. Mindfulness-oriented recovery enhancement for chronic pain and prescription opioid misuse: results from an early-stage randomized controlled trial. J Consult Clin Psychol. 2014;82(3):448.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Brewer JA, Mallik S, Babuscio TA, Nich C, Johnson HE, Deleone CM, et al. Mindfulness training for smoking cessation: results from a randomized controlled trial. Drug Alcohol Depend. 2011;119(1–2):72–80.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Brewer J. Mindfulness training for addictions: has neuroscience revealed a brain hack by which awareness subverts the addictive process? Curr Opin Psychol. 2019;28:198–203.

    Article  PubMed  Google Scholar 

  34. Brewer JA, Elwafi HM, Davis JH. Craving to quit: psychological models and neurobiological mechanisms of mindfulness training as treatment for addictions. 2014.

  35. Koob GF, Le Moal M. Drug abuse: hedonic homeostatic dysregulation. Science. 1997;278(5335):52–8.

    Article  CAS  PubMed  Google Scholar 

  36. Goldstein RZ, Volkow ND. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. Am J Psychiatry. 2002;159(10):1642–52.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Volkow ND, Fowler JS, Wang G-J. The addicted human brain: insights from imaging studies. J Clin Investig. 2003;111(10):1444–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Schultz W, Dayan P, Montague PR. A neural substrate of prediction and reward. Science. 1997;275(5306):1593–9.

    Article  CAS  PubMed  Google Scholar 

  39. Lüscher C, Malenka RC. Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron. 2011;69(4):650–63.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Belin D, Jonkman S, Dickinson A, Robbins TW, Everitt BJ. Parallel and interactive learning processes within the basal ganglia: relevance for the understanding of addiction. Behav Brain Res. 2009;199(1):89–102.

    Article  PubMed  Google Scholar 

  41. Koob GF, Bloom FE. Cellular and molecular mechanisms of drug dependence. Science. 1988;242(4879):715–23.

    Article  CAS  PubMed  Google Scholar 

  42. Martinez D, Narendran R, Foltin RW, Slifstein M, Hwang D-R, Broft A, et al. Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine. Am J Psychiatry. 2007;164(4):622–9.

    Article  PubMed  Google Scholar 

  43. Cunningham KA, Anastasio NC. Serotonin at the nexus of impulsivity and cue reactivity in cocaine addiction. Neuropharmacology. 2014;76:460–78.

    Article  CAS  PubMed  Google Scholar 

  44. Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, et al. Addiction as a stress surfeit disorder. Neuropharmacology. 2014;76:370–82.

    Article  CAS  PubMed  Google Scholar 

  45. Delfs J, Zhu Y, Druhan J, Aston-Jones G. Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion. Nature. 2000;403(6768):430–4.

    Article  CAS  PubMed  Google Scholar 

  46. Fotros A, Casey KF, Larcher K, Verhaeghe JA, Cox SM, Gravel P, et al. Cocaine cue-induced dopamine release in amygdala and hippocampus: a high-resolution PET [18 F] fallypride study in cocaine dependent participants. Neuropsychopharmacology. 2013;38(9):1780–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Volkow ND, Wang G-J, Telang F, Fowler JS, Logan J, Childress A-R, et al. Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction. J Neurosci. 2006;26(24):6583–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Volkow ND, Wang G-J, Fowler JS, Tomasi D, Telang F. Addiction: beyond dopamine reward circuitry. Proc Natl Acad Sci. 2011;108(37):15037–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Jasinska AJ, Stein EA, Kaiser J, Naumer MJ, Yalachkov Y. Factors modulating neural reactivity to drug cues in addiction: a survey of human neuroimaging studies. Neurosci Biobehav Rev. 2014;38:1–16.

    Article  PubMed  Google Scholar 

  50. Koob GF. Negative reinforcement in drug addiction: the darkness within. Curr Opin Neurobiol. 2013;23(4):559–63.

    Article  CAS  PubMed  Google Scholar 

  51. Khalsa SS, Adolphs R, Cameron OG, Critchley HD, Davenport PW, Feinstein JS, et al. Interoception and mental health: a roadmap. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;3(6):501–13.

    PubMed  Google Scholar 

  52. Critchley HD, Harrison NA. Visceral influences on brain and behavior. Neuron. 2013;77(4):624–38.

    Article  CAS  PubMed  Google Scholar 

  53. Craig AD. How do you feel? Interoception: the sense of the physiological condition of the body. Nat Rev Neurosci. 2002;3(8):655–66.

    Article  CAS  PubMed  Google Scholar 

  54. Naqvi NH, Bechara A. The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making. Brain Struct Funct. 2010;214(5–6):435–50.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Medford N, Critchley HD. Conjoint activity of anterior insular and anterior cingulate cortex: awareness and response. Brain Struct Funct. 2010;214(5–6):535–49.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Engelmann JM, Versace F, Robinson JD, Minnix JA, Lam CY, Cui Y, et al. Neural substrates of smoking cue reactivity: a meta-analysis of fMRI studies. Neuroimage. 2012;60(1):252–62.

    Article  PubMed  Google Scholar 

  57. Schacht JP, Anton RF, Myrick H. Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review. Addict Biol. 2013;18(1):121–33.

    Article  PubMed  Google Scholar 

  58. Duncan E, Boshoven W, Harenski K, Duncan E, Boshoven W, Harenski K, et al. An fMRI study of the interaction of stress and cocaine cues on cocaine craving in cocaine-dependent men. Am J Addict. 2007;16(3):174–82.

    Article  PubMed  Google Scholar 

  59. Kilts CD, Gross RE, Ely TD, Drexler KP. The neural correlates of cue-induced craving in cocaine-dependent women. Am J Psychiatry. 2004;161(2):233–41.

    Article  PubMed  Google Scholar 

  60. Huang Y, Mohan A, De Ridder D, Sunaert S, Vanneste S. The neural correlates of the unified percept of alcohol-related craving: a fMRI and EEG study. Sci Rep. 2018;8(1):1–12.

    Google Scholar 

  61. Fukushima S, Kuga H, Oribe N, Mutou T, Yuzuriha T, Ozawa H, et al. Behavioural cue reactivity to alcohol-related and non-alcohol-related stimuli among individuals with alcohol use disorder: An fMRI study with a visual task. PLoS ONE. 2020;15(7):e0229187.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Moningka H, Lichenstein S, Worhunsky PD, DeVito EE, Scheinost D, Yip SW. Can neuroimaging help combat the opioid epidemic? A systematic review of clinical and pharmacological challenge fMRI studies with recommendations for future research. Neuropsychopharmacology. 2019;44(2):259–73.

    Article  PubMed  Google Scholar 

  63. Kosten TR, Scanley BE, Tucker KA, Oliveto A, Prince C, Sinha R, et al. Cue-induced brain activity changes and relapse in cocaine-dependent patients. Neuropsychopharmacology. 2006;31(3):644–50.

    Article  CAS  PubMed  Google Scholar 

  64. Sinha R, Li CS. Imaging stress-and cue-induced drug and alcohol craving: association with relapse and clinical implications. Drug Alcohol Rev. 2007;26(1):25–31.

    Article  PubMed  Google Scholar 

  65. Kabat-Zinn J. Wherever you go, there you are: mindfulness meditation in everyday life: Hachette Books; 2009.

  66. Tang Y-Y, Hölzel BK, Posner MI. The neuroscience of mindfulness meditation. Nat Rev Neurosci. 2015;16(4):213.

    Article  CAS  PubMed  Google Scholar 

  67. Vøllestad J, Nielsen MB, Nielsen GH. Mindfulness-and acceptance-based interventions for anxiety disorders: a systematic review and meta-analysis. Br J Clin Psychol. 2012;51(3):239–60.

    Article  PubMed  Google Scholar 

  68. Strauss C, Cavanagh K, Oliver A, Pettman D. Mindfulness-based interventions for people diagnosed with a current episode of an anxiety or depressive disorder: a meta-analysis of randomised controlled trials. PLoS ONE. 2014;9(4):e96110.

    Article  PubMed  PubMed Central  Google Scholar 

  69. Eisendrath SJ, Gillung E, Delucchi KL, Segal ZV, Nelson JC, McInnes LA, et al. A randomized controlled trial of mindfulness-based cognitive therapy for treatment-resistant depression. Psychother Psychosom. 2016;85(2):99–110.

    Article  PubMed  Google Scholar 

  70. Ma SH, Teasdale JD. Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects. J Consult Clin Psychol. 2004;72(1):31.

    Article  PubMed  Google Scholar 

  71. Teasdale JD, Segal ZV, Williams JMG, Ridgeway VA, Soulsby JM, Lau MA. Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J Consult Clin Psychol. 2000;68(4):615.

    Article  CAS  PubMed  Google Scholar 

  72. Treanor M. The potential impact of mindfulness on exposure and extinction learning in anxiety disorders. Clin Psychol Rev. 2011;31(4):617–25.

    Article  PubMed  Google Scholar 

  73. Brewer JA, Garrison KA. The posterior cingulate cortex as a plausible mechanistic target of meditation: findings from neuroimaging. Ann N Y Acad Sci. 2014;1307(1):19–27.

    Article  PubMed  Google Scholar 

  74. Roemer L, Orsillo SM. Mindfulness-and acceptance-based behavioral therapies in practice. Guilford Press; 2010.

  75. Cohen ZP, Cosgrove KT, Akeman E, Coffey S, Teague K, Hays-Grudo J, et al. The effect of a mindfulness-based stress intervention on neurobiological and symptom measures in adolescents with early life stress: a randomized feasibility study. BMC Complement Med Ther. 2021;21(1):1–14.

    Article  Google Scholar 

  76. Kirlic N, Cohen ZP, Singh MK. Is there an ACE up our sleeve? A review of interventions and strategies for addressing behavioral and neurobiological effects of adverse childhood experiences in youth. Adversity and Resilience Science. 2020;1–24.

  77. Davis MC, Zautra AJ, Wolf LD, Tennen H, Yeung EW. Mindfulness and cognitive–behavioral interventions for chronic pain: differential effects on daily pain reactivity and stress reactivity. J Consult Clin Psychol. 2015;83(1):24.

    Article  PubMed  Google Scholar 

  78. Ludwig DS, Kabat-Zinn J. Mindfulness in medicine. JAMA. 2008;300(11):1350–2.

    Article  CAS  PubMed  Google Scholar 

  79. Black DS, Slavich GM. Mindfulness meditation and the immune system: a systematic review of randomized controlled trials. Ann N Y Acad Sci. 2016;1373(1):13–24.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Gaylord SA, Palsson OS, Garland EL, Faurot KR, Coble RS, Mann JD, et al. Mindfulness training reduces the severity of irritable bowel syndrome in women: results of a randomized controlled trial. Am J Gastroenterol. 2011;106(9):1678.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Black DS, O’Reilly GA, Olmstead R, Breen EC, Irwin MR. Mindfulness meditation and improvement in sleep quality and daytime impairment among older adults with sleep disturbances: a randomized clinical trial. JAMA Intern Med. 2015;175(4):494–501.

    Article  PubMed  PubMed Central  Google Scholar 

  82. Buckner RL, Andrews-Hanna JR, Schacter DL. The brain's default network: anatomy, function, and relevance to disease. 2008.

  83. Leech R, Sharp DJ. The role of the posterior cingulate cortex in cognition and disease. Brain. 2014;137(1):12–32.

    Article  PubMed  Google Scholar 

  84. Andrews-Hanna JR, Reidler JS, Sepulcre J, Poulin R, Buckner RL. Functional-anatomic fractionation of the brain’s default network. Neuron. 2010;65(4):550–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  85. Farb NA, Segal ZV, Mayberg H, Bean J, McKeon D, Fatima Z, et al. Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference. Soc Cogn Affect Neurosci. 2007;2(4):313–22.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Grant JA, Courtemanche J, Rainville P. A non-elaborative mental stance and decoupling of executive and pain-related cortices predicts low pain sensitivity in Zen meditators. PAIN®. 2011;152(1):150–6.

    Article  Google Scholar 

  87. Taylor VA, Grant J, Daneault V, Scavone G, Breton E, Roffe-Vidal S, et al. Impact of mindfulness on the neural responses to emotional pictures in experienced and beginner meditators. Neuroimage. 2011;57(4):1524–33.

    Article  PubMed  Google Scholar 

  88. Brewer JA, Worhunsky PD, Gray JR, Tang Y-Y, Weber J, Kober H. Meditation experience is associated with differences in default mode network activity and connectivity. Proc Natl Acad Sci. 2011;108(50):20254–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Hölzel BK, Ott U, Hempel H, Hackl A, Wolf K, Stark R, et al. Differential engagement of anterior cingulate and adjacent medial frontal cortex in adept meditators and non-meditators. Neurosci Lett. 2007;421(1):16–21.

    Article  PubMed  Google Scholar 

  90. Kober H, Barrett LF, Joseph J, Bliss-Moreau E, Lindquist K, Wager TD. Functional grouping and cortical–subcortical interactions in emotion: a meta-analysis of neuroimaging studies. Neuroimage. 2008;42(2):998–1031.

    Article  PubMed  Google Scholar 

  91. Sheline YI, Barch DM, Price JL, Rundle MM, Vaishnavi SN, Snyder AZ, et al. The default mode network and self-referential processes in depression. Proc Natl Acad Sci. 2009;106(6):1942–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Zhao X-H, Wang P-J, Li C-B, Hu Z-H, Xi Q, Wu W-Y, et al. Altered default mode network activity in patient with anxiety disorders: an fMRI study. Eur J Radiol. 2007;63(3):373–8.

    Article  PubMed  Google Scholar 

  93. Garavan H, Pankiewicz J, Bloom A, Cho J-K, Sperry L, Ross TJ, et al. Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. Am J Psychiatry. 2000;157(11):1789–98.

    Article  CAS  PubMed  Google Scholar 

  94. Chiesa A, Serretti A. Are mindfulness-based interventions effective for substance use disorders? A systematic review of the evidence. Subst Use Misuse. 2014;49(5):492–512.

    Article  PubMed  Google Scholar 

  95. Bowen S, Witkiewitz K, Clifasefi SL, Grow J, Chawla N, Hsu SH, et al. Relative efficacy of mindfulness-based relapse prevention, standard relapse prevention, and treatment as usual for substance use disorders: a randomized clinical trial. JAMA Psychiat. 2014;71(5):547–56.

    Article  Google Scholar 

  96. Zgierska A, Rabago D, Zuelsdorff M, Coe C, Miller M, Fleming M. Mindfulness meditation for alcohol relapse prevention: a feasibility pilot study. J Addict Med. 2008;2(3):165.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Imani S, Vahid MKA, Gharraee B, Noroozi A, Habibi M, Bowen S. Effectiveness of mindfulness-based group therapy compared to the usual opioid dependence treatment. Iran J Psychiatry. 2015;10(3):175.

    PubMed  PubMed Central  Google Scholar 

  98. Davis JM, Goldberg SB, Anderson MC, Manley AR, Smith SS, Baker TB. Randomized trial on mindfulness training for smokers targeted to a disadvantaged population. Subst Use Misuse. 2014;49(5):571–85.

    Article  PubMed  PubMed Central  Google Scholar 

  99. Davis JM, Manley AR, Goldberg SB, Smith SS, Jorenby DE. Randomized trial comparing mindfulness training for smokers to a matched control. J Subst Abuse Treat. 2014;47(3):213–21.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Vidrine JI, Spears CA, Heppner WL, Reitzel LR, Marcus MT, Cinciripini PM, et al. Efficacy of mindfulness-based addiction treatment (MBAT) for smoking cessation and lapse recovery: a randomized clinical trial. J Consult Clin Psychol. 2016;84(9):824.

    Article  PubMed  PubMed Central  Google Scholar 

  101. Lotfalian S, Spears CA, Juliano LM. The effects of mindfulness-based yogic breathing on craving, affect, and smoking behavior. Psychol Addict Behav. 2020;34(2):351.

    Article  PubMed  Google Scholar 

  102. Witkiewitz K, Bowen S. Depression, craving, and substance use following a randomized trial of mindfulness-based relapse prevention. J Consult Clin Psychol. 2010;78(3):362.

    Article  PubMed  PubMed Central  Google Scholar 

  103. Zemestani M, Ottaviani C. Effectiveness of mindfulness-based relapse prevention for co-occurring substance use and depression disorders. Mindfulness. 2016;7(6):1347–55.

    Article  Google Scholar 

  104. Glasner S, Mooney LJ, Ang A, Garneau HC, Hartwell E, Brecht M-L, et al. Mindfulness-based relapse prevention for stimulant dependent adults: a pilot randomized clinical trial. Mindfulness. 2017;8(1):126–35.

    Article  Google Scholar 

  105. Witkiewitz K, Warner K, Sully B, Barricks A, Stauffer C, Thompson BL, et al. Randomized trial comparing mindfulness-based relapse prevention with relapse prevention for women offenders at a residential addiction treatment center. Subst Use Misuse. 2014;49(5):536–46.

    Article  PubMed  Google Scholar 

  106. Garland EL, Roberts-Lewis A, Tronnier CD, Graves R, Kelley K. Mindfulness-Oriented Recovery Enhancement versus CBT for co-occurring substance dependence, traumatic stress, and psychiatric disorders: Proximal outcomes from a pragmatic randomized trial. Behav Res Ther. 2016;77:7–16.

    Article  PubMed  Google Scholar 

  107. Tang Y-Y, Tang R, Posner MI. Brief meditation training induces smoking reduction. Proc Natl Acad Sci. 2013;110(34):13971–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. Bloom-Foster J, Mehl-Madrona L. An ultra-brief mindfulness-based intervention for patients in treatment for opioid addiction with buprenorphine: a primary care feasibility pilot study. J Alternat Complement Med. 2020;26(1):34–43.

    Article  Google Scholar 

  109. Ostafin BD, Bauer C, Myxter P. Mindfulness decouples the relation between automatic alcohol motivation and heavy drinking. J Soc Clin Psychol. 2012;31(7):729–45.

    Article  Google Scholar 

  110. Garland EL, Farb NA, Goldin RP, Fredrickson BL. Mindfulness broadens awareness and builds eudaimonic meaning: a process model of mindful positive emotion regulation. Psychol Inquiry. 2015;26(4):293–314.

    Article  Google Scholar 

  111. Garland E. Restructuring reward processing with Mindfulness-Oriented Recovery Enhancement: novel therapeutic mechanisms to remediate hedonic dysregulation in addiction, stress, and pain. Ann N Y Acad Sci. 2016;1373(1):25.

    Article  PubMed  PubMed Central  Google Scholar 

  112. Froeliger B, Mathew A, McConnell P, Eichberg C, Saladin M, Carpenter M, et al. Restructuring reward mechanisms in nicotine addiction: a pilot fMRI study of mindfulness-oriented recovery enhancement for cigarette smokers. Evid Based Complement Alternat Med. 2017;2017.

  113. Kringelbach ML, Rolls ET. The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Prog Neurobiol. 2004;72(5):341–72.

    Article  PubMed  Google Scholar 

  114. Kober H, Brewer JA, Height KL, Sinha R. Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments. Neuroimage. 2017;151:4–13.

    Article  PubMed  Google Scholar 

  115. Westbrook C, Creswell JD, Tabibnia G, Julson E, Kober H, Tindle HA. Mindful attention reduces neural and self-reported cue-induced craving in smokers. Soc Cogn Affect Neurosci. 2013;8(1):73–84.

    Article  PubMed  Google Scholar 

  116. Hudak J, Hanley AW, Marchand WR, Nakamura Y, Yabko B, Garland EL. Endogenous theta stimulation during meditation predicts reduced opioid dosing following treatment with Mindfulness-Oriented Recovery Enhancement. Neuropsychopharmacology. 2021;46(4):836–43.

    Article  CAS  PubMed  Google Scholar 

  117. Carroll H, Lustyk MKB. Mindfulness-based relapse prevention for substance use disorders: effects on cardiac vagal control and craving under stress. Mindfulness. 2018;9(2):488–99.

    Article  PubMed  Google Scholar 

  118. Brewer JA, Sinha R, Chen JA, Michalsen RN, Babuscio TA, Nich C, et al. Mindfulness training and stress reactivity in substance abuse: results from a randomized, controlled stage I pilot study. Substance Abuse. 2009;30(4):306–17.

    Article  PubMed  Google Scholar 

  119. Paz R, Zvielli A, Goldstein P, Bernstein A. Brief mindfulness training de-couples the anxiogenic effects of distress intolerance on reactivity to and recovery from stress among deprived smokers. Behav Res Ther. 2017;95:117–27.

    Article  PubMed  Google Scholar 

  120. Goldberg SB, Manley AR, Smith SS, Greeson JM, Russell E, Van Uum S, et al. Hair cortisol as a biomarker of stress in mindfulness training for smokers. J Alternat Complement Med. 2014;20(8):630–4.

    Article  Google Scholar 

  121. Garland EL, Atchley RM, Hanley AW, Zubieta J-K, Froeliger B. Mindfulness-Oriented Recovery Enhancement remediates hedonic dysregulation in opioid users: neural and affective evidence of target engagement. Sci Adv. 2019;5(10):eaax1569.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  122. Brown DR, Jackson TC, Claus ED, Votaw VR, Stein ER, Robinson CS, et al. Decreases in the late positive potential to alcohol images among alcohol treatment seekers following mindfulness-based relapse prevention. Alcohol Alcohol. 2020;55(1):78–85.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

This work was in part supported by the P20 GM121312 award from the National Institute of General Medical Sciences and the William K. Warren Foundation.

Author information

Authors and Affiliations

  1. Laureate Institute for Brain Research, 6655 South Yale Ave, Tulsa, OK, 74136, USA

    Namik Kirlic, Zsofia Cohen & Jennifer L. Stewart

  2. School of Community Medicine, University of Tulsa, Tulsa, OK, USA

    Jennifer L. Stewart

Authors
  1. Namik Kirlic
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zsofia Cohen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jennifer L. Stewart
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Namik Kirlic.

Ethics declarations

Ethics Approval and Consent to Participate

This article does not contain any studies with human or animal subjects performed by any Human and Animal Rights and Informed Consent of the authors.

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Neuroscience & Addiction

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kirlic, N., Cohen, Z. & Stewart, J.L. Neurocircuitry of Mindfulness-Based Interventions for Substance Use Prevention and Recovery. Curr Addict Rep 8, 520–529 (2021). https://doi.org/10.1007/s40429-021-00396-2

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40429-021-00396-2

Keywords

Search

Navigation