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Co-use of Alcohol and Cannabis: A Review

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Abstract

Purpose of Review

The purpose of this review is to provide an overview of the existing literature on the relationship between the co-use of cannabis and alcohol including (1) epidemiology, comorbidity, and associated consequences of cannabis and alcohol use disorders; (2) preclinical and clinical laboratory studies examining behavioral pharmacology of cannabis and alcohol co-use; and (3) clinical outcomes related to co-use.

Recent Findings

Findings from the literature reviewed suggest that the co-use of alcohol and cannabis is associated with additive performance impairment effects, higher and more frequent consumption levels, increased social and behavioral consequences such as driving while impaired, and greater likelihood of the experiencing comorbid substance use and mental health disorders. Furthermore, co-use may be associated with worse clinical outcomes, yet there are few studies examining the development and evaluation of interventions on reducing the co-use of cannabis and alcohol.

Summary

There is a need for more rigorous and longitudinal research studies on the co-use of cannabis and alcohol to glean a more complete understanding of the relationship between the two substances. Findings can be used to develop and refine intervention strategies to successfully reduce cannabis and alcohol co-use.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Agrawal A, Lynskey MT, Madden PAF, Bucholz KK, Heath AC. A latent class analysis of illicit drug abuse/dependence: results from the National Epidemiological Survey on Alcohol and Related Conditions. Addict Abingdon Engl. 2007;102(1):94–104.

    Article  Google Scholar 

  2. Midanik LT, Tam TW, Weisner C. Concurrent and simultaneous drug and alcohol use: results of the 2000 National Alcohol Survey. Drug Alcohol Depend. 2007;90(1):72–80.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Stinson FS, Ruan WJ, Pickering R, Grant BF. Cannabis use disorders in the USA: prevalence, correlates and co-morbidity. Psychol Med. 2006;36(10):1447–60.

    Article  PubMed  Google Scholar 

  4. Substance Abuse and Mental Health Service Administration (SAMHSA). Results from the 2013 National survey on drug use and health: summary of national findings. NSDUH Series H-48, HHS Publication No.(SMA) 14–4863. Rockville: Substance Abuse and Mental Health Services Administration; 2014.

  5. Barrett SP, Darredeau C, Pihl RO. Patterns of simultaneous polysubstance use in drug using university students. Hum Psychopharmacol Clin Exp. 2006;21(4):255–63.

    Article  Google Scholar 

  6. Collins RL, Ellickson PL, Bell RM. Simultaneous polydrug use among teens: prevalence and predictors. J Subst Abus. 1998;10(3):233–53.

    Article  CAS  Google Scholar 

  7. Pape H, Rossow I, Storvoll EE. Under double influence: assessment of simultaneous alcohol and cannabis use in general youth populations. Drug Alcohol Depend. 2009;101(1–2):69–73.

    Article  PubMed  Google Scholar 

  8. Haas AL, Wickham R, Macia K, Shields M, Macher R, Schulte T. Identifying classes of conjoint alcohol and marijuana use in entering freshmen. Psychol Addict Behav J Soc Psychol Addict Behav. 2015;29(3):620–6.

    Article  Google Scholar 

  9. Subbaraman MS, Kerr WC. Simultaneous versus concurrent use of alcohol and cannabis in the national alcohol survey. Alcohol Clin Exp Res. 2015;39(5):872–9.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Hayaki J, Anderson BJ, Stein MD. Dual cannabis and alcohol use disorders in young adults: problems magnified. Subst Abuse. 2016;37(4):579–83.

    Article  Google Scholar 

  11. Center for Behavioral Health Statistics and Quality. Key substance use and mental health indicators in the United States: Results from the 2015 National Survey on Drug Use and Health. (NSDUH Series H-51). Report No.: HHS Publication No. SMA 16–4984; 2016.

  12. ProCon.org [Internet]. http://medicalmarijuana.procon.org/view.resource.php?resourceID=000881. Available from: http://medicalmarijuana.procon.org/view.resource.php?resourceID=000881 (2016). Cited 2017 Jan 18.

  13. Brière FN, Fallu J-S, Descheneaux A, Janosz M. Predictors and consequences of simultaneous alcohol and cannabis use in adolescents. Addict Behav. 2011;36(7):785–8.

    Article  PubMed  Google Scholar 

  14. Martin CS, Kaczynski NA, Maisto SA, Tarter RE. Polydrug use in adolescent drinkers with and without DSM-IV alcohol abuse and dependence. Alcohol Clin Exp Res. 1996;20(6):1099–108.

    Article  CAS  PubMed  Google Scholar 

  15. Terry-McElrath YM, O’Malley PM, Johnston LD. Alcohol and marijuana use patterns associated with unsafe driving among U.S. high school seniors: high use frequency, concurrent use, and simultaneous use. J Stud Alcohol Drugs. 2014;75(3):378–89.

    Article  PubMed  PubMed Central  Google Scholar 

  16. SAMHSA. Results from the 2010 national survey on drug use and health: summary of national findings, vol NSDUH, Series H-41, HHS Publication No. (SMA) 11–4658. Rockville: Substance Abuse and Mental Health Services Administration; 2011.

  17. Stinson FS, Ruan WJ, Pickering R, Grant BF. Cannabis use disorders in the USA: prevalence, correlates and co-morbidity. Psychol Med. 2006;36(10):1447–60.

    Article  PubMed  Google Scholar 

  18. Agosti V, Nunes E, Levin F. Rates of psychiatric comorbidity among U.S. residents with lifetime cannabis dependence. Am J Drug Alcohol Abuse. 2002;28(4):643–52.

    Article  PubMed  Google Scholar 

  19. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA J Am Med Assoc. 1990;264(19):2511–8.

    Article  CAS  Google Scholar 

  20. Hill KP. Cannabis use and risk for substance use disorders and mood or anxiety disorders. JAMA. 2017;317(10):1070–1.

    Article  PubMed  Google Scholar 

  21. Agrawal A, Lynskey MT, Madden PAF, Bucholz KK, Heath AC. A latent class analysis of illicit drug abuse/dependence: results from the National Epidemiological Survey on Alcohol and Related Conditions. Addict Abingdon Engl. 2007;102(1):94–104.

    Article  Google Scholar 

  22. Copeland WE, Angold A, Shanahan L, Dreyfuss J, Dlamini I, Costello EJ. Predicting persistent alcohol problems: a prospective analysis from the Great Smoky Mountain Study. Psychol Med. 2012;42(9):1925–35.

    Article  CAS  PubMed  Google Scholar 

  23. Weinberger AH, Platt J, Goodwin RD. Is cannabis use associated with an increased risk of onset and persistence of alcohol use disorders? A three-year prospective study among adults in the United States. Drug Alcohol Depend. 2016;161:363–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Novak SP, Peiper NC, Zarkin GA. Nonmedical prescription pain reliever and alcohol consumption among cannabis users. Drug Alcohol Depend. 2016;159:101–8.

    Article  PubMed  Google Scholar 

  25. O’Grady KE, Arria AM, Fitzelle DMB, Wish ED. Heavy drinking and polydrug use among college students. J Drug Issues. 2008;38(2):445–65.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Green KM, Musci RJ, Johnson RM, Matson PA, Reboussin BA, Ialongo NS. Outcomes associated with adolescent marijuana and alcohol use among urban young adults: a prospective study. Addict Behav. 2016;53:155–60.

    Article  PubMed  Google Scholar 

  27. Magill M, Barnett NP, Apodaca TR, Rohsenow DJ, Monti PM. The role of marijuana use in brief motivational intervention with young adult drinkers treated in an emergency department. J Stud Alcohol Drugs. 2009;70(3):409–13.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Magill M, Barnett NP, Apodaca TR, Rohsenow DJ, Monti PM. The role of marijuana use in brief motivational intervention with young adult drinkers treated in an emergency department. J Stud Alcohol Drugs. 2009;70(3):409–13.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Shillington AM, Clapp JD. Substance use problems reported by college students: combined marijuana and alcohol use versus alcohol-only use. Subst Use Misuse. 2001;36(5):663–72.

    Article  CAS  PubMed  Google Scholar 

  30. Shillington AM, Clapp JD. Heavy alcohol use compared to alcohol and marijuana use: do college students experience a difference in substance use problems? J Drug Educ. 2006;36(1):91–103.

    Article  PubMed  Google Scholar 

  31. Simons JS, Carey KB. An affective and cognitive model of marijuana and alcohol problems. Addict Behav. 2006;31(9):1578–92.

    Article  PubMed  Google Scholar 

  32. Simons JS, Maisto SA, Wray TB. Sexual risk taking among young adult dual alcohol and marijuana users. Addict Behav. 2010;35(5):533–6.

    Article  PubMed  Google Scholar 

  33. • Terry-McElrath YM, O’Malley PM, Johnston LD. Simultaneous alcohol and marijuana use among U.S. high school seniors from 1976 to 2011: trends, reasons, and situations. Drug Alcohol Depend. 2013;133(1):71–9. This is an important longitudinal study examining trends of co-use and consequences experienced. Findings contributed to research linking co-use to increased consumption levels and related consequences of both alcohol and cannabis

    Article  PubMed  PubMed Central  Google Scholar 

  34. Pacek LR, Malcolm RJ, Martins SS. Race/ethnicity differences between alcohol, marijuana, and co-occurring alcohol and marijuana use disorders and their association with public health and social problems using a national sample. Am J Addict. 2012;21(5):435–44.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Trull TJ, Wycoff AM, Lane SP, Carpenter RW, Brown WC. Cannabis and alcohol use, affect and impulsivity in psychiatric out-patients’ daily lives. Addiction. 2016;111(11):2052–9.

    Article  PubMed  Google Scholar 

  36. Harrington M, Baird J, Lee C, Nirenberg T, Longabaugh R, Mello MJ, et al. Identifying subtypes of dual alcohol and marijuana users: a methodological approach using cluster analysis. Addict Behav. 2012;37(1):119–23.

    Article  PubMed  Google Scholar 

  37. Metrik J, Caswell AJ, Magill M, Monti PM, Kahler CW. Sexual risk behavior and heavy drinking among weekly marijuana users. J Stud Alcohol Drugs. 2016;77(1):104–12.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Stein MD, Caviness CM, Anderson BJ. Alcohol use potentiates marijuana problem severity in young adult women. Womens Health Issues Off Publ Jacobs Inst Womens Health. 2014;24(1):e77–82.

    Article  Google Scholar 

  39. Parks KA, Lorraine R, Derrick JL. The influence of marijuana and alcohol use on condom use behavior: findings from a sample of young adult female bar drinkers. Psychol Addict Behav. 2012;26(4):888–94.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Biecheler M-B, Peytavin J-F, Sam Group, Facy F, Martineau H. SAM survey on “drugs and fatal accidents”: search of substances consumed and comparison between drivers involved under the influence of alcohol or cannabis. Traffic Inj Prev. 2008;9(1):11–21.

    Article  PubMed  Google Scholar 

  41. Ronen A, Chassidim HS, Gershon P, Parmet Y, Rabinovich A, Bar-Hamburger R, et al. The effect of alcohol, THC and their combination on perceived effects, willingness to drive and performance of driving and non-driving tasks. Accid Anal Prev. 2010;42(6):1855–65.

    Article  PubMed  Google Scholar 

  42. Bramness JG, Khiabani HZ, Mørland J. Impairment due to cannabis and ethanol: clinical signs and additive effects. Addict Abingdon Engl. 2010;105(6):1080–7.

    Article  Google Scholar 

  43. Johnson MB, Kelley-Baker T, Voas RB, Lacey JH. The prevalence of cannabis-involved driving in California. Drug Alcohol Depend. 2012;123(1–3):105–9.

    Article  PubMed  Google Scholar 

  44. Li M-C, Brady JE, DiMaggio CJ, Lusardi AR, Tzong KY, Li G. Marijuana use and motor vehicle crashes. Epidemiol Rev. 2012;34(1):65–72.

    Article  CAS  PubMed  Google Scholar 

  45. Salomonsen-Sautel S, Min S-J, Sakai JT, Thurstone C, Hopfer C. Trends in fatal motor vehicle crashes before and after marijuana commercialization in Colorado. Drug Alcohol Depend. 2014;140:137–44.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Mehmedic Z, Chandra S, Slade D, Denham H, Foster S, Patel AS, et al. Potency trends of Δ9-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008. J Forensic Sci. 2010;55(5):1209–17.

    Article  CAS  PubMed  Google Scholar 

  47. Vindenes V, Strand DH, Kristoffersen L, Boix F, Mørland J. Has the intake of THC by cannabis users changed over the last decade? Evidence of increased exposure by analysis of blood THC concentrations in impaired drivers. Forensic Sci Int. 2013;226(1–3):197–201.

    Article  CAS  PubMed  Google Scholar 

  48. Brunette MF, Noordsy DL, Xie H, Drake RE. Benzodiazepine use and abuse among patients with severe mental illness and co-occurring substance use disorders. Psychiatr Serv. 2003;54(10):1395–401.

    Article  PubMed  Google Scholar 

  49. •• Hasin DS, Kerridge BT, Saha TD, Huang B, Pickering R, Smith SM, et al. Prevalence and correlates of DSM-5 cannabis use disorder, 2012-2013: findings from the national epidemiologic survey on alcohol and related conditions–III. Am J Psychiatry. 2016;173(6):588–99. This important study examined the relationship between cannabis use disorders (CUD) and other psychiatric disorders. The authors concluded that having a CUD is associated with the occurrence of other substance use disorders (SUD), mood disorders, anxiety disorders, post-traumatic stress disorder (PTSD), and personality disorders

    Article  PubMed  Google Scholar 

  50. Conway KP, Swendsen J, Husky MM, He J-P, Merikangas KR. Association of lifetime mental disorders and subsequent alcohol and illicit drug use: results from the National Comorbidity Survey–Adolescent Supplement. J Am Acad Child Adolesc Psychiatry. 2016;55(4):280–8.

    Article  PubMed  Google Scholar 

  51. Jacobus J, McQueeny T, Bava S, Schweinsburg BC, Frank LR, Yang TT, et al. White matter integrity in adolescents with histories of marijuana use and binge drinking. Neurotoxicol Teratol. 2009;31(6):349–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  52. Jacobus J, Tapert SF. Effects of cannabis on the adolescent brain. Curr Pharm Des. 2014;20(13):2186–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Jacobus J, Squeglia LM, Sorg SF, Nguyen-Louie TT, Tapert SF. Cortical thickness and neurocognition in adolescent marijuana and alcohol users following 28 days of monitored abstinence. J Stud Alcohol Drugs. 2014;75(5):729–43.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Epstein KA, Kumra S. Altered cortical maturation in adolescent cannabis users with and without schizophrenia. Schizophr Res. 2015;162(1):143–52.

    Article  PubMed  Google Scholar 

  55. Jacobus J, Squeglia LM, Meruelo AD, Castro N, Brumback T, Giedd JN, et al. Cortical thickness in adolescent marijuana and alcohol users: a three-year prospective study from adolescence to young adulthood. Dev Cogn Neurosci. 2015;16:101–9.

    Article  PubMed  PubMed Central  Google Scholar 

  56. Chassin L, Dmitrieva J, Modecki K, Steinberg L, Cauffman E, Piquero AR, et al. Does adolescent alcohol and marijuana use predict suppressed growth in psychosocial maturity among male juvenile offenders? Psychol Addict Behav. 2010;24(1):48.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Colombo G, Serra S, Vacca G, Carai MAM, Gessa GL. Endocannabinoid system and alcohol addiction: pharmacological studies. Pharmacol Biochem Behav. 2005 Jun;81(2):369–80.

    Article  CAS  PubMed  Google Scholar 

  58. Hungund BL, Basavarajappa BS. Role of endocannabinoids and cannabinoid CB1 receptors in alcohol-related behaviors. Ann N Y Acad Sci. 2004 Oct;1025:515–27.

    Article  CAS  PubMed  Google Scholar 

  59. López-Moreno JA, Echeverry-Alzate V, Bühler K-M. The genetic basis of the endocannabinoid system and drug addiction in humans. J Psychopharmacol Oxf Engl. 2012;26(1):133–43.

    Article  Google Scholar 

  60. Pava MJ, Woodward JJ. A review of the interactions between alcohol and the endocannabinoid system: implications for alcohol dependence and future directions for research. Alcohol Fayettev N. 2012;46(3):185–204.

    Article  CAS  Google Scholar 

  61. Femenía T, García-Gutiérrez MS, Manzanares J. CB1 receptor blockade decreases ethanol intake and associated neurochemical changes in fawn-hooded rats. Alcohol Clin Exp Res. 2010;34(1):131–41.

    Article  PubMed  Google Scholar 

  62. Basavarajappa BS, Yalamanchili R, Cravatt BF, Cooper TB, Hungund BL. Increased ethanol consumption and preference and decreased ethanol sensitivity in female FAAH knockout mice. Neuropharmacology. 2006;50(7):834–44.

    Article  CAS  PubMed  Google Scholar 

  63. Alen F, Moreno-Sanz G, Isabel de Tena A, Brooks RD, López-Jimenez A, Navarro M, et al. Pharmacological activation of CB1 and D2 receptors in rats: predominant role of CB1 in the increase of alcohol relapse. Eur J Neurosci. 2008;27(12):3292–8.

    Article  PubMed  Google Scholar 

  64. Malinen H, Hyytiä P. Ethanol self-administration is regulated by CB1 receptors in the nucleus accumbens and ventral tegmental area in alcohol-preferring AA rats. Alcohol Clin Exp Res. 2008;32(11):1976–83.

    CAS  PubMed  Google Scholar 

  65. Chait LD, Perry JL. Acute and residual effects of alcohol and marijuana, alone and in combination, on mood and performance. Psychopharmacology. 1994;115(3):340–9.

    Article  CAS  PubMed  Google Scholar 

  66. Chait LD, Perry JL. Effects of alcohol pretreatment on human marijuana self-administration. Psychopharmacology. 1994;113(3–4):346–50.

    Article  CAS  PubMed  Google Scholar 

  67. Perez-Reyes M, Hicks RE, Bumberry J, Jeffcoat AR, Cook CE. Interaction between marihuana and ethanol: effects on psychomotor performance. Alcohol Clin Exp Res. 1988;12(2):268–76.

    Article  CAS  PubMed  Google Scholar 

  68. Ramaekers JG, Robbe HWJ, O’Hanlon JF. Marijuana, alcohol and actual driving performance. Hum Psychopharmacol. 2000;15(7):551–8.

    Article  PubMed  Google Scholar 

  69. Ramaekers JG, Theunissen EL, de Brouwer M, Toennes SW, Moeller MR, Kauert G. Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users. Psychopharmacology. 2011;214(2):391–401.

    Article  CAS  PubMed  Google Scholar 

  70. • Hartman RL, Brown TL, Milavetz G, Spurgin A, Pierce RS, Gorelick DA, et al. Cannabis effects on driving longitudinal control with and without alcohol. J Appl Toxicol JAT. 2016;36(11):1418–29. This study investigated the effect of cannabis on driving with and without alcohol on THC blood concentrations in a within-subject study with six conditions. This study added to the co-use literature by suggesting co-use is related to riskier driving behaviors

    Article  CAS  PubMed  Google Scholar 

  71. Lukas SE, Benedikt R, Mendelson JH, Kouri E, Sholar M, Amass L. Marihuana attenuates the rise in plasma ethanol levels in human subjects. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol. 1992;7(1):77–81.

    CAS  Google Scholar 

  72. Lukas SE, Orozco S. Ethanol increases plasma Delta(9)-tetrahydrocannabinol (THC) levels and subjective effects after marihuana smoking in human volunteers. Drug Alcohol Depend. 2001;64(2):143–9.

    Article  CAS  PubMed  Google Scholar 

  73. Ballard ME, de Wit H. Combined effects of acute, very-low-dose ethanol and delta(9)-tetrahydrocannabinol in healthy human volunteers. Pharmacol Biochem Behav. 2011;97(4):627–31.

    Article  CAS  PubMed  Google Scholar 

  74. •• Hartman RL, Brown TL, Milavetz G, Spurgin A, Gorelick DA, Gaffney G, et al. Controlled cannabis vaporizer administration: blood and plasma cannabinoids with and without alcohol. Clin Chem. 2015;61(6):850–69. This study employed vaporized cannabis administration to investigate the effect of cannabis and alcohol co-use on subsequent cannabinoid plasma levels. Findings indicated that the inclusion of alcohol was related to significantly higher blood cannabinoid levels

    Article  CAS  PubMed  Google Scholar 

  75. Hartman RL, Brown TL, Milavetz G, Spurgin A, Gorelick DA, Gaffney G, et al. Controlled vaporized cannabis, with and without alcohol: subjective effects and oral fluid-blood cannabinoid relationships. Drug Test Anal. 2016;8(7):690–701.

    Article  CAS  PubMed  Google Scholar 

  76. Peters EN, Hughes JR. Daily marijuana users with past alcohol problems increase alcohol consumption during marijuana abstinence. Drug Alcohol Depend. 2010;106(2–3):111–8.

    Article  PubMed  Google Scholar 

  77. Schuckit MA, Smith TL, Kalmijn JA. The patterns of drug and alcohol use and associated problems over 30 years in 397 men. Alcohol Clin Exp Res. 2014;38(1):227–34.

    Article  PubMed  Google Scholar 

  78. Dutra L, Stathopoulou G, Basden SL, Leyro TM, Powers MB, Otto MW. A meta-analytic review of psychosocial interventions for substance use disorders. Am J Psychiatry. 2008;165(2):179–87.

    Article  PubMed  Google Scholar 

  79. Metrik J, Spillane NS, Leventhal AM, Kahler CW. Marijuana use and tobacco smoking cessation among heavy alcohol drinkers. Drug Alcohol Depend. 2011;119(3):194–200.

    Article  PubMed  PubMed Central  Google Scholar 

  80. Alessi SM, Rash C, Petry NM. Contingency management is efficacious and improves outcomes in cocaine patients with pretreatment marijuana use. Drug Alcohol Depend. 2011;118(1):62–7.

    Article  PubMed  PubMed Central  Google Scholar 

  81. Gourlay SG, Forbes A, Marriner T, Pethica D, McNeil JJ. Prospective study of factors predicting outcome of transdermal nicotine treatment in smoking cessation. BMJ. 1994;309(6958):842–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Mojarrad M, Samet JH, Cheng DM, Winter MR, Saitz R. Marijuana use and achievement of abstinence from alcohol and other drugs among people with substance dependence: a prospective cohort study. Drug Alcohol Depend. 2014;142:91–7.

    Article  CAS  PubMed  Google Scholar 

  83. Subbaraman MS, Metrik J, Patterson D, Swift R. Cannabis use during treatment for alcohol use disorders predicts alcohol treatment outcomes. Addiction. 2016;112:685–694.

  84. Jonas DE, Amick HR, Feltner C, Bobashev G, Thomas K, Wines R, et al. Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and meta-analysis. JAMA. 2014;311(18):1889–900.

    Article  PubMed  Google Scholar 

  85. Keating GM. Nalmefene: a review of its use in the treatment of alcohol dependence. CNS Drugs. 2013;27(9):761–72.

    Article  CAS  PubMed  Google Scholar 

  86. Scott-Sheldon LA, Carey KB, Elliott JC, Garey L, Carey MP. Efficacy of alcohol interventions for first-year college students: a meta-analytic review of randomized controlled trials. J Consult Clin Psychol. 2014;82(2):177.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Tanner-Smith EE, Lipsey MW. Brief alcohol interventions for adolescents and young adults: a systematic review and meta-analysis. J Subst Abus Treat. 2015;51:1–18.

    Article  Google Scholar 

  88. VanBuskirk KA, Wetherell JL. Motivational interviewing with primary care populations: a systematic review and meta-analysis. J Behav Med. 2014;37(4):768–80.

    Article  PubMed  Google Scholar 

  89. Budney AJ, Roffman R, Stephens RS, Walker D. Marijuana dependence and its treatment. Alcohol. 2007;50:60.

    Google Scholar 

  90. Budney AJ, Stanger C, Tilford JM, Scherer EB, Brown PC, Li Z, et al. Computer-assisted behavioral therapy and contingency management for cannabis use disorder. Psychol Addict Behav. 2015;29(3):501.

    Article  PubMed  PubMed Central  Google Scholar 

  91. Davis ML, Powers MB, Handelsman P, Medina JL, Zvolensky M, Smits JA. Behavioral therapies for treatment-seeking cannabis users: a meta-analysis of randomized controlled trials. Eval Health Prof. 2015;38(1):94–114.

    Article  PubMed  Google Scholar 

  92. Metrik J, Ramesh D. Treatment of marijuana use disorders. In: MacKillop J, Kenna GA, Leggio L, Ray LA, editors. Integrating psychological and pharmacological treatments for addictive disorders: an evidence-based guide. New York: Routledge Press; 2017.

    Google Scholar 

  93. Hogue A, Henderson CE, Ozechowski TJ, Robbins MS. Evidence base on outpatient behavioral treatments for adolescent substance use: updates and recommendations 2007–2013. J Clin Child Adolesc Psychol. 2014;43(5):695–720.

    Article  PubMed  Google Scholar 

  94. Woolard R, Baird J, Longabaugh R, Nirenberg T, Lee CS, Mello MJ, et al. Project reduce: reducing alcohol and marijuana misuse: effects of a brief intervention in the emergency department. Addict Behav. 2013;38(3):1732–9.

    Article  PubMed  Google Scholar 

  95. Yurasek AM, Dennhardt AA, Murphy JG. A randomized controlled trial of a behavioral economic intervention for alcohol and marijuana use. Exp Clin Psychopharmacol. 2015;23(5):332–8.

    Article  PubMed  PubMed Central  Google Scholar 

  96. White HR, Jiao Y, Ray AE, Huh D, Atkins DC, Larimer ME, et al. Are there secondary effects on marijuana use from brief alcohol interventions for college students? J Stud Alcohol Drugs. 2015;76(3):367–77.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Simons JS, Gaher RM, Correia CJ, Hansen CL, Christopher MS. An affective-motivational model of marijuana and alcohol problems among college students. Psychol Addict Behav J Soc Psychol Addict Behav. 2005;19(3):326–34.

    Article  Google Scholar 

  98. McCambridge J, Strang J. The efficacy of single-session motivational interviewing in reducing drug consumption and perceptions of drug-related risk and harm among young people: results from a multi-site cluster randomized trial. Addict Abingdon Engl. 2004;99(1):39–52.

    Article  Google Scholar 

  99. White HR, Morgan TJ, Pugh LA, Celinska K, Labouvie EW, Pandina RJ. Evaluating two brief substance-use interventions for mandated college students. J Stud Alcohol. 2006;67(2):309–17.

    Article  PubMed  Google Scholar 

  100. White HR, Mun EY, Pugh L, Morgan TJ. Long-term effects of brief substance use interventions for mandated college students: sleeper effects of an in-person personal feedback intervention. Alcohol Clin Exp Res. 2007;31(8):1380–91.

    Article  PubMed  Google Scholar 

  101. Hartman RL, Brown TL, Milavetz G, Spurgin A, Gorelick DA, Gaffney GR, et al. Effect of blood collection time on measured Δ9-tetrahydrocannabinol concentrations: implications for driving interpretation and drug policy. Clin Chem. 2016;62(2):367–77.

    Article  CAS  PubMed  Google Scholar 

  102. National Academies of Sciences E. The health effects of cannabis and cannabinoids: the current state of evidence and recommendations for research [Internet]. Available from: https://www.nap.edu/catalog/24625/the-health-effects-of-cannabis-and-cannabinoids-the-current-state 2017. Cited 2017 Jan 22.

  103. Palamar JJ, Ompad DC, Petkova E. Correlates of intentions to use cannabis among US high school seniors in the case of cannabis legalization. Int J Drug Policy. 2014;2

  104. NIH launches landmark study on substance use and adolescent brain development [Internet]. EurekAlert! [cited 2017 Jan 22]. Available from: http://www.eurekalert.org/pub_releases/2015-09/niod-nll092515.php.

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Correspondence to Ali M. Yurasek.

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Dr. Ali M. Yurasek declares that she has no conflicts of interest. Dr. Elizabeth R. Aston declares an NIDA grant. Dr. Jane Metrik declares an NIAAA grant.

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Yurasek, A.M., Aston, E.R. & Metrik, J. Co-use of Alcohol and Cannabis: A Review. Curr Addict Rep 4, 184–193 (2017). https://doi.org/10.1007/s40429-017-0149-8

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