Current Addiction Reports

, Volume 3, Issue 4, pp 445–449 | Cite as

Neurobiology of Disordered Gambling

  • Jon E. Grant
Gambling (J Derevensky, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Gambling



Gambling disorder affects 0.4 to 1.9 % of adults worldwide and is commonly associated with significant psychosocial dysfunction.


This article provides a concise primer on recent research examining the neurobiological underpinnings of gambling disorder.


Although impulsivity has been seen as one cognitive component underlying gambling disorder, compulsivity may be equally important to examine. Although causality remains elusive, structural and functional neuroimaging data suggest dysfunction in top-down executive control in gambling disorder. Recent twin research suggests that gambling disorder may have genetic links to both gambling and to obsessive-compulsive disorder.


Understanding the neurobiology of gambling disorder may lead to improved treatment approaches.


Gambling Cognition Neuroimaging Genetics 


Compliance with Ethical Standards

Conflict of Interest

Dr. Jon Grant has received research grant support from NIDA, NCRG, Brainsway, TLC Foundation for Body Focused Repetitive Behaviors, the American Foundation for Suicide Prevention, Psyadon Pharmaceuticals, Forest Pharmaceuticals, Roche Pharmaceuticals, and Takeda Pharmaceuticals. He has also received royalties from American Psychiatric Publishing Inc., Oxford University Press, Norton, Johns Hopkins Press, and McGraw Hill Publishers.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Department of Psychiatry & Behavioral Neuroscience, Pritzker School of MedicineUniversity of ChicagoChicagoUSA

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