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Alternative root canal filling materials to zinc oxide eugenol in primary teeth: a systematic review of the literature

  • Systematic Review
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Abstract

Purpose

The aim of this review was to compare the currently available root canal filling materials for primary teeth to zinc oxide eugenol (ZOE) to find a suitable alternative. The search question was: which root canal filling materials used in pulpectomy for primary teeth give better clinical and radiographic success rates than ZOE?

Methods

A systematic search was conducted using five databases, namely Cochrane central register of controlled trials (CENTRAL), MEDLINE via PubMed, Science Direct, Scopus and EBSCOhost using a selection of “MeSH terms”. The “Modified Jadad Scale” was used for the methodology assessment of the included studies.

Results

Out of 480 articles identified in the initial search, 8 articles met all the inclusion criteria. The results showed that, compared to ZOE, ZOE with calcium hydroxide and iodoform had better clinical and radiographic success rates, a resorption rate similar to that of the roots, faster resorption of extruded particles and a maximum decrease in the size of pre-operative inter-radicular radiolucencies.

Conclusion

Numerous materials, proposed and used by clinicians in root canal filling in primary teeth, can be recommended as alternatives to ZOE. However, none of them could be the ideal material in primary teeth. Thus, more high-quality well-designed randomised clinical trials are required to develop more high-performing materials.

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All relevant data (Flowchart, tables) are available on request.

References

  • American Academy on Pediatric Dentistry Clinical Affairs Committee-Pulp Therapy subcommittee, American Academy on Pediatric Dentistry Council on Clinical Affairs. Guideline on pulp therapy for primary and young permanent teeth. Pediatr Dent. 2005;27(7 Suppl):130–4.

  • American Academy on Pediatric Dentistry Clinical Affairs Committee-Pulp Therapy subcommittee, American Academy on Pediatric Dentistry Council on Clinical Affairs. Guideline on pulp therapy for primary and young permanent teeth. Pediatr Dent. 2009;30(7 Suppl):170–4.

  • Al-Ostwani AO, Al-Monaqel BM, Al-Tinawi MK. A clinical and radiographic study of four different root canal fillings in primary molars. J Indian Soc Pedod Prev Dent. 2016;34(1):55–9. https://doi.org/10.4103/0970-4388.175515.

    Article  PubMed  Google Scholar 

  • Barja-Fidalgo F, Moutinho-Ribeiro M, Oliveira MA, de Oliveira BH. A systematic review of root canal filling materials for deciduous teeth: is there an alternative for zinc oxide-eugenol? ISRN Dent. 2011;2011:367318. https://doi.org/10.5402/2011/367318.

  • Bawazir OA, Salama FS. Clinical evaluation of root canal obturation methods in primary teeth. Pediatr Dent. 2006;28(1):39–47.

    PubMed  Google Scholar 

  • Bhardwaj A, Ballal S, Velmurugan N. Comparative evaluation of the antimicrobial activity of natural extracts of Morinda citrifolia, papain and aloe vera (all in gel formulation), 2% chlorhexidine gel and calcium hydroxide, against Enterococcus faecalis: An in vitro study. J Conserv Dent. 2012;15(3):293–7. https://doi.org/10.4103/0972-0707.97964.

    Article  PubMed  PubMed Central  Google Scholar 

  • Brar GS, Bajaj N, Bhola M, Brar JK. Clinical evaluation of root resorption and its correlation with obturation quality in pulpectomized deciduous teeth with different obturating materials: an in vivo study. Contemp Clin Dent. 2019;10(2):243–8. https://doi.org/10.4103/ccd.ccd_448_18.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chandra SP, Chandrasekhar R, Uloopi KS, Vinay C, Kumar NM. Success of root fillings with zinc oxide-ozonated oil in primary molars: preliminary results. Eur Arch Paediatr Dent. 2014;15(3):191–5. https://doi.org/10.1007/s40368-013-0094-8.

    Article  PubMed  Google Scholar 

  • Chen X, Liu X, Zhong J. Clinical and radiographic evaluation of pulpectomy in primary teeth: a 18-months clinical randomized controlled trial. Head Face Med. 2017;13(1):12. https://doi.org/10.1186/s13005-017-0145-1.

    Article  PubMed  PubMed Central  Google Scholar 

  • Coll JA, Vargas K, Marghalani AA, Chen CY, AlShamali S, Dhar V, Crystal YO. A systematic review and meta-analysis of nonvital pulp therapy for primary teeth. Pediatr Dent. 2020;42(4):256–461.

    PubMed  Google Scholar 

  • Doneria D, Thakur S, Singhal P, Chauhan D. Comparative evaluation of clinical and radiological success of zinc oxide-ozonated oil, modified 3mix-mp antibiotic paste, and vitapex as treatment options in primary molars requiring pulpectomy: An in vivo study. J Indian Soc Pedod Prev Dent. 2017;35(4):346–52. https://doi.org/10.4103/JISPPD.JISPPD_359_16.

    Article  PubMed  Google Scholar 

  • Fuks AB, Eidelman E, Pauker N. Root fillings with Endoflas in primary teeth: a retrospective study. J Clin Pediatr Dent. 2002;27(1):41–5. https://doi.org/10.17796/jcpd.27.1.pp237453707386m1.

  • Goel H, Mathur S, Sachdev V. Clinical and radiographic evaluation of four different zinc-oxide integrated root canal obturating materials used in primary teeth. Pediatr Dent J. 2018;28(2):73–86. https://doi.org/10.1016/J.PDJ.2018.06.002.

    Article  Google Scholar 

  • Goinka C, Reddy KS, Ganapathi A, Nallagula KH, Kondapaneni A, Sunil VVN. Comparative evaluation of three different an obturating materials in pulpectomy; an in vivo study. Indian J Dental Sc. 2020;12(2):68–72. https://doi.org/10.4103/IJDS.IJDS_1_2.

    Article  Google Scholar 

  • Gupta B, Singh I, Goyal P, Garg S, Gupta S. A clinical and radiographic study of four different root canal filling materials in primary molars—an in vivo study. Dental J Adv Stud. 2019;7(2):61–5. https://doi.org/10.1055/s-0039-1692611.

    Article  Google Scholar 

  • Hachem CE, Chedid JCA, Nehme W, Kaloustian MK, Ghosn N, Sahnouni H, Mancino D, Haikel Y, Kharouf N. Physicochemical and antibacterial properties of conventional and two premixed root canal filling materials in primary teeth. J Funct Biomater. 2022;13(4):177. https://doi.org/10.3390/jfb13040177.

    Article  PubMed  PubMed Central  Google Scholar 

  • Khairwa A, Bhat M, Sharma R, Satish V, Maganur P, Goyal AK. Clinical and radiographic evaluation of zinc oxide with aloe vera as an obturating material in pulpectomy: an in vivo study. J Indian Soc Pedod Prev Dent. 2014;32(1):33–8. https://doi.org/10.4103/0970-4388.127051.

    Article  PubMed  Google Scholar 

  • Mittal M, Chandra S, Chandra S. Comparative tissue toxicity evaluation of four endodontic sealers. J Endod. 1995;21(12):622–4. https://doi.org/10.1016/S0099-2399(06)81116-7.

    Article  PubMed  Google Scholar 

  • Moness AM, Khattab NN, Waly NG. Evaluation of three root canal filling materials for primary teeth (in vivo and in vitro study). Egypt Dent J. 2013;59(4):50–7.

    Google Scholar 

  • Najjar RS, Alamoudi NM, El-Housseiny AA, Al Tuwirqi AA, Sabbagh HJ. A comparison of calcium hydroxide/iodoform paste and zinc oxide eugenol as root filling materials for pulpectomy in primary teeth: a systematic review and meta-analysis. Clin Exp Dent Res. 2019;5(3):294–310. https://doi.org/10.1002/cre2.173.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ou-Yang LW, Chang PC, Chuang LC, Yu HT, Tsai AI. Treatment outcomes of pulpectomy in primary maxillary incisors filled with ZOE and Metapex: a two-year retrospective study. J Clin Pediatr Dent. 2021;45(2):83–9. https://doi.org/10.17796/1053-4625-45.2.3.

    Article  PubMed  Google Scholar 

  • Ozalp N, Saroglu I, Sonmez H. Evaluation of various root canal filling materials in primary molar pulpectomies: an in vivo study. Am J Dentistry. 2005;18:347–50.

    Google Scholar 

  • Pandranki J, V Vanga NR, Chandrabhatla SK. Zinc oxide eugenol and Endoflas pulpectomy in primary molars: 24-month clinical and radiographic evaluation. J Indian Soc Pedod Prev Dent. 2018;36(2):173–180. https://doi.org/10.4103/JISPPD.JISPPD_1179_17.

  • Pramila R, Muthu MS, Deepa G, Farzan JM, Rodrigues SJ. Pulpectomies in primary mandibular molars: a comparison of outcomes using three root filling materials. Int Endod J. 2016;49(5):413–21. https://doi.org/10.1111/iej.12478.

    Article  PubMed  Google Scholar 

  • Ramar K, Mungara J. Clinical and radiographic evaluation of pulpectomies using three root canal filling materials: an in-vivo study. J Indian Soc Pedod Prev Dent. 2010;28(1):25–9. https://doi.org/10.4103/0970-4388.60481.

    Article  PubMed  Google Scholar 

  • Rewal N, Thakur AS, Sachdev V, Mahajan N. Comparison of endoflas and zinc oxide eugenol as root canal filling materials in primary dentition. J Indian Soc Pedod Prev Dent. 2014;32(4):317–21. https://doi.org/10.4103/0970-4388.140958.

    Article  PubMed  Google Scholar 

  • RojaRamya KS, Vinay C, Uloopi KS, Chandrasekhar R. In vivo evaluation of zinc oxide-propolis mixture as root canal filling material in the primary molars: a 24-month follow-up randomized controlled trial. J Indian Soc Pedod Prev Dent. 2020;38(2):171–6. https://doi.org/10.4103/JISPPD.JISPPD_127_20.

    Article  PubMed  Google Scholar 

  • Subramaniam P, Gilhotra K. Endoflas, zinc oxide eugenol and metapex as root canal filling materials in primary molars—a comparative clinical study. J Clin Pediatr Dent. 2011;35(4):365–9. https://doi.org/10.17796/jcpd.35.4.1377v06621143233.

  • Trairatvorakul C, Chunlasikaiwan S. Success of pulpectomy with zinc oxide-eugenol vs calcium hydroxide/iodoform paste in primary molars: a clinical study. Pediatr Dent. 2008;30(4):303–8.

    PubMed  Google Scholar 

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Funding

This review received no grant from any funding agency in the public commercial or not for profit sectors.

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Contributions

Systematic search was conducted by Miniar Rhaiem. Study selection and data collection were performed by Miniar Rhaiem, Yamina Elelmi and Ahlem Baaziz. Writing—original draft preparation was done by Miniar Rhaiem and Yamina Elelmi. Written —Review and editing were performed by Marwa Chatti and Fethi Maatouk. Hichem Ghedira provided comprehensive judgement and assisted in editing the final version of the manuscript.

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Correspondence to M. Rhaiem.

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Rhaiem, M., Elelmi, Y., Baaziz, A. et al. Alternative root canal filling materials to zinc oxide eugenol in primary teeth: a systematic review of the literature. Eur Arch Paediatr Dent 24, 533–547 (2023). https://doi.org/10.1007/s40368-023-00839-6

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  • DOI: https://doi.org/10.1007/s40368-023-00839-6

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