Abstract
Purpose
Estimate the incidence of teething symptoms and investigate risk factors at three centers in different regions of Brazil.
Methods
A prospective cohort study enrolled children at birth in the cities of Manaus (northern region), Porto Alegre (southern region) and Salvador (northeast region). Sociodemographic and anthropometric variables were collected at baseline and 6 months. At 12 months, data were collected on the child's health through structured interviews and dental examinations, including the primary outcome: occurrence of signs and symptoms of tooth eruption reported by parents. Statistical analysis involved Poisson regression with robust variance, with calculation of relative risks (RR).
Results
The incidence of teething symptoms was 82.4% (238/289). The multivariate analysis revealed a higher occurrence of the outcome in the city of Salvador (RR = 1.39; 95% CI 1.23–1.58), when mother’s education was more than 11 years (RR = 1.31; 95% CI 1.04–1.65), when a larger number of individuals resided in the home (RR = 1.15; 95% CI 1.02–1.29), when a smoker resided in the home (RR = 1.16; 95% CI 1.03–1.31) and when the child presented flu or cold in the first year of life (RR = 1.23; 95% CI 1.09–1.38). The most reported symptoms were fever (50.5%), irritability (42.6%), itching (40.8%) and diarrhea (35.3%). Most parents (82%) took some action to alleviate symptoms, including unprescribed systemic medication, such as analgesic, anti-inflammatory and anti-diarrheic agents.
Conclusion
Reports of teething symptoms were associated with the city investigated, socioeconomic factors of the families and characteristics of the child's health. A high rate of administering unprescribed medication was also found.
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Acknowledgements
The work was supported by the National Council for Scientific and Technological Development (CNPq) (No. 408125/2017-9).
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The study received approval from the Human Research Ethics Committee of Universidade Federal de Ciências da Saúde de Porto Alegre (No. 88214918.3.0000.5345). All parents signed a statement of informed consent after receiving clarifications regarding the intervention and all phases of the data collection process. This study was performed in line with the principles of the Declaration of Helsinki.
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Mantelli, A.R., Kramer, P.F., Vítolo, M.R. et al. Clinical manifestations of tooth eruption in the first year of life and related risk factors in three regions of Brazil: multicenter birth cohort study. Eur Arch Paediatr Dent 24, 63–73 (2023). https://doi.org/10.1007/s40368-022-00761-3
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DOI: https://doi.org/10.1007/s40368-022-00761-3