Skip to main content

Chemotherapy-induced oral mucositis in children and adolescents: a systematic review

Abstract

Purpose

The present systematic review aims to describe the incidence and severity of chemotherapy-related oral mucositis in children and adolescents affected by hematologic and solid tumors.

Methods

An electronic search was performed on PubMed, Scopus, Web of Science, Cochrane Library, and EBSCO up to the 8th November 2020. The PRISMA protocol was followed for the article selection and inclusion. The risk of bias in individual studies was evaluated through the Newcastle–Ottawa Scale. Data were summarized using mean and standard deviation for continuous variables, while categorical ones were described with frequency and percentage.

Results

A number of 9940 records were obtained after the electronic search. Seventeen of them were included in the qualitative analysis after the two stages of screening, while none of these articles was considered eligible for the quantitative analysis. The mean incidence of oral mucositis was 53.6% and it ranged from 16.7 to 91.5%, while severe oral mucositis accounted for the 15.8% (0.0–35.2%) among selected studies. Most of the articles included both patients with solid and hematologic tumors, while only five of them described oral mucositis in children with acute lymphoblastic leukemia. Even the kinds of chemotherapy administered were extremely variable.

Conclusion

In conclusion, about half of the patients submitted to cancer chemotherapy developed oral mucositis with an incidence and severity that varies depending on the primary disease and the kind of drugs administered.

This is a preview of subscription content, access via your institution.

Fig. 1

Availability of data and materials

Not applicable.

Code availability

Not applicable.

References

Download references

Funding

No funds, grants, or other support was received.

Author information

Authors and Affiliations

Authors

Contributions

BC and DR contributed to the study conception and design. Material preparation, data collection, and analysis were performed by BC. The first draft of the manuscript was written by BC and DR, while BC and AMD participated in the revision process. All authors read and approved the final manuscript.

Corresponding author

Correspondence to C. Bensi.

Ethics declarations

Conflict of interest

The authors have no conflicts of interest to declare that are relevant to the content of this article.

Ethics approval

Not required.

Consent to participate

Not applicable.

Consent for publication

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Docimo, R., Anastasio, M.D. & Bensi, C. Chemotherapy-induced oral mucositis in children and adolescents: a systematic review. Eur Arch Paediatr Dent 23, 501–511 (2022). https://doi.org/10.1007/s40368-022-00727-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40368-022-00727-5

Keywords

  • Oral mucositis
  • Children
  • Incidence
  • Chemotherapy
  • Pediatric cancer