European Archives of Paediatric Dentistry

, Volume 18, Issue 3, pp 155–161 | Cite as

Is there sufficient evidence to support an optimum time for the extraction of first permanent molars?

  • M. Wu
  • L. Chen
  • E. Bawole
  • R. P. AnthonappaEmail author
  • N. M. King
Systematic Review



To evaluate whether the literature contains evidence, of an appropriate quality, to support the fundamental belief that there is an “optimal time” for extraction of FPMs with a poor prognosis.


A comprehensive search, limited to human studies, was performed using five databases. PICO based inclusion and exclusion criteria were employed to facilitate article selection. Three independent reviewers assessed the quality of included studies using STROBE and GRADE criteria.


Initially, 56 articles were selected, of which 9 were included for final assessments. None of the included studies obtained moderate or high GRADE level rating and neither did they meet all of the STROBE requirements with only one study satisfying 95%, and another study satisfying 73%, of the requirements. The inter-observer agreement was excellent.


There is no scientific evidence, of an appropriate quality, to support the “optimal time” for extraction of FPMs with a poor prognosis.


Extraction First permanent molar Optimum time 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

This article does not contain any studies with human participants performed by any of the authors.

Informed consent

Informed consent was not essential for this review.


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Copyright information

© European Academy of Paediatric Dentistry 2017

Authors and Affiliations

  • M. Wu
    • 1
  • L. Chen
    • 1
  • E. Bawole
    • 1
  • R. P. Anthonappa
    • 2
    Email author
  • N. M. King
    • 2
  1. 1.School of DentistryThe University of Western AustraliaNedlands, PerthAustralia
  2. 2.Paediatric Oral Health Research Group, School of DentistryThe University of Western AustraliaNedlands, PerthAustralia

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