European Archives of Paediatric Dentistry

, Volume 17, Issue 2, pp 115–122 | Cite as

Retrospective review of oral and maxillofacial pathology in a Brazilian paediatric population

  • R. B. CavalcanteEmail author
  • E. Turatti
  • A. P. B. Daniel
  • G. F. de Alencar
  • Z. Chen



To describe the relative frequencies of oral biopsies among a sample of children aged 0–16 years and compare the results with an adult population as well as with previous studies.


Information about age, gender, anatomic site, and histopathological diagnosis was retrieved from the files of the Oral Pathology Laboratory of the University of Fortaleza (Brazil). Diagnosis data of 1240 biopsies were classified into eight groups.


Relative frequencies of biopsies increased with age. The 16 most frequent lesions accounted for 70 % of all biopsies. The most frequent diagnostic group was salivary gland pathology (30.4 %). Mucocele was the most common lesion (27.1 %), followed by dental follicle (5.6 %) and fibroma (4.4 %). These results were statistically different from those of the comparable adult population (p < 0.05).


The most frequent lesion was mucocele, and this result is in agreement with the literature. There was a significant difference between the study paediatric and adult populations. The variations in distribution of lesions observed between the several studies were probably due to cultural differences between geographic areas but also to differing elements of the study design.


Paediatrics Oral pathology Biopsy Epidemiology 


Compliance with ethical standards

Conflict of interest



  1. Brazil. Brazilian Statistical and Geography Institute. 2010 population census: characteristics of the population. Rio de Janeiro: IBGE; 2010. p. 2010.Google Scholar
  2. Chen JY, Wang WC, Chen YK, et al. A retrospective study of trauma-associated oral and maxillofacial lesions in a population from southern Taiwan. J Appl Oral Sci. 2010;18:5–9.CrossRefPubMedGoogle Scholar
  3. Chen YK, Lin LM, Huang HC, et al. A retrospective study of oral and maxillofacial biopsy lesions in a pediatric population from southern Taiwan. Pediatr Dent. 1998;20:404–10.PubMedGoogle Scholar
  4. Chi AC, Lambert PR 3rd, Richardson MS, et al. Oral mucoceles: a clinicopathologic review of 1,824 cases, including unusual variants. J Oral Maxillofac Surg. 2011;69:1086–93.CrossRefPubMedGoogle Scholar
  5. Das S, Das AK. A review of pediatric oral biopsies from a surgical pathology service in a dental school. Pediatr Dent. 1993;15:208–11.PubMedGoogle Scholar
  6. Dhanuthai K, Banrai M, Limpanaputtajak S. A retrospective study of paediatric oral lesions from Thailand. Int J Paediatr Dent. 2007;17:248–53.CrossRefPubMedGoogle Scholar
  7. Dhanuthai K, Rojanawatsirivej S, Somkotra T, et al. Geriatric oral lesions: a multicentric study. Geriatr Gerontol Int 2015. doi: 10.1111/ggi.12458.
  8. Fregnani ER, Fillipi RZ, Oliveira CR, et al. Odontomas and ameloblastomas: variable prevalences around the world? Oral Oncol. 2002;38:807–8.CrossRefPubMedGoogle Scholar
  9. Ha WN, Kelloway E, Dost F, et al. A retrospective analysis of oral and maxillofacial pathology in an Australian paediatric population. Aust Dent J. 2014;59:221–5.CrossRefPubMedGoogle Scholar
  10. Jones AV, Franklin CD. An analysis of oral and maxillofacial pathology found in children over a 30-year period. Int J Paediatr Dent. 2006;16:19–30.CrossRefPubMedGoogle Scholar
  11. Kelloway E, Ha WN, Dost F, et al. A retrospective analysis of oral and maxillofacial pathology in an Australian adult population. Aust Dent J. 2014;59:215–20.CrossRefPubMedGoogle Scholar
  12. Keszler A, Guglielmotti MB, Dominguez FV. Oral pathology in children. Frequency, distribution and clinical significance. Acta Odontol Latinoam. 1990;5:39–48.PubMedGoogle Scholar
  13. Lei F, Chen JY, Lin LM, et al. Retrospective study of biopsied oral and maxillofacial lesions in pediatric patients from southern Taiwan. J Dent Sci. 2014;9:351–8.CrossRefGoogle Scholar
  14. Lima GS, Fontes ST, de Araújo LM, et al. A survey of oral and maxillofacial biopsies in children: a single-center retrospective study of 20 years in Pelotas-Brazil. J Appl Oral Sci. 2008;16:397–402.CrossRefPubMedCentralGoogle Scholar
  15. Maia DM, Merly F, Castro WH, et al. A survey of oral biopsies in Brazilian pediatric patients. ASDC J Dent Child. 2000;67:128–31.PubMedGoogle Scholar
  16. Nico MMS, Park JH, Lourenço SV. Mucocele in pediatric patients: analysis of 36 children. Pediatr Dermatol. 2008;25:308–11.CrossRefPubMedGoogle Scholar
  17. Nogueira RL, Teixeira RC, Cavalcante RB, et al. Intralesional injection of triamcinolone as an alternative treatment for giant-cell granuloma in 21 cases. Int J Oral Maxillofac Surg. 2010;39:1204–10.CrossRefPubMedGoogle Scholar
  18. Nogueira RL, Faria MH, Osterne RL, et al. Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy. Int J Oral Maxillofac Surg. 2012;41:994–1000.CrossRefPubMedGoogle Scholar
  19. Shah SK, Le MC, Carpenter WM. Retrospective review of pediatric oral lesions from a dental school biopsy service. Pedriatr Dent. 2009;31:14–9.Google Scholar
  20. Skinner RL, Davenport WD Jr, Weir JC, et al. A survey of biopsied oral lesions in pediatric dental patients. Pediatr Dent. 1986;8:163–7.PubMedGoogle Scholar
  21. Sousa FB, Etges A, Corrêa L, et al. Pediatric oral lesions: a 15-year review from São Paulo, Brazil. J Clin Pediatr Dent. 2002;26:413–8.CrossRefPubMedGoogle Scholar
  22. Teixeira RC, Horz HP, Damante JH, et al. SH3BP2-encoding exons involved in cherubism are not associated with central giant cell granuloma. Int J Oral Maxillofac Surg. 2011;40:851–5.CrossRefPubMedGoogle Scholar
  23. Wang YL, Chang HH, Chang JY, et al. Retrospective survey of biopsied oral lesions in pediatric population. J Formos Med Assoc. 2009;108:862–71.CrossRefPubMedGoogle Scholar
  24. Zuñiga MD, Méndez CR, Kauterich RR, et al. Paediatric oral pathology in a Chilean population: a 15-year review. Int J Paediatr Dent. 2012;23:346–51.CrossRefPubMedGoogle Scholar

Copyright information

© European Academy of Paediatric Dentistry 2015

Authors and Affiliations

  1. 1.Division of Oral Pathology, School of DentistryUniversity of FortalezaFortalezaBrazil
  2. 2.Division of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public HealthUniversity of ArizonaTucsonUSA

Personalised recommendations