In November 2014, a review of literature concerning prevalence data of Molar Incisor Hypomineralisation (MIH) and Hypomineralised Second Primary Molars (HSPM) was performed. A search of PubMed online databases was conducted for relevant articles published until November 2014. The reference lists of all retrieved articles were hand-searched. Studies were included after assessing the eligibility of the full-text article. Out of 1078 manuscripts, a total of 157 English written publications were selected based on title and abstract. Of these 157, 60 were included in the study and allocated as 52 MIH and 5 HSPM, and 3 for both MIH and HSPM. These studies utilised the European Academy of Paediatric Dentistry judgment criteria, the modified index of developmental defects of enamel (mDDE) and self-devised criteria, and demonstrated a wide variation in the reported prevalence (MIH 2.9–44 %; HSPM 0–21.8 %). Most values mentioned were representative for specific areas. More studies were performed in cities compared with rural areas. A great variation was found in calibration methods, number of participants, number of examiners and research protocols between the studies. The majority of the prevalence studies also investigated possible aetiological factors. To compare MIH and HSPM prevalence and or aetiological data around the world, standardisation of such studies seems essential. Standardisation of the research protocol should include a clearly described sample of children (minimum number of 300 for prevalence and 1000 for aetiology studies) and use of the same calibration sets and methods whereas aetiological studies need to be prospective in nature. A standardised protocol for future MIH and HSPM prevalence and aetiology studies is recommended.
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Ahmadi R, Ramazani N, Nourinasab R. Molar incisor hypomineralization: a study of prevalence and etiology in a group of Iranian children. Iran J Pediatr. 2012;22(2):245–51.
Alaluusua S. Aetiology of molar-incisor hypomineralisation: a systematic review. Eur Arch Paediatr Dent. 2010;11(2):53–8.
Alaluusua S, Lukinmaa PL, Koskimies M, et al. Developmental dental defects associated with long breast feeding. Eur J Oral Sci. 1996a;104(5–6):493–7.
Alaluusua S, Lukinmaa PL, Vartiainen T, et al. Polychlorinated dibenzo-p-dioxins and dibenzofurans via mother’s milk may cause developmental defects in the child’s teeth. Environ Toxicol Pharmacol. 1996b;1:193–7.
Allazzam SM, Alaki SM, El Meligy OA. Molar incisor hypomineralization, prevalence, and etiology. Int J Dent. 2014. doi:10.1155/2014/234508.
Balmer R, Toumba J, Godson J, Duggal M. The prevalence of molar incisor hypomineralisation in Northern England and its relationship to socioeconomic status and water fluoridation. Int J Paediatr Dent. 2012;22(4):250–7.
Balmer RC, Laskey D, Mahoney E, Toumba KJ. Prevalence of enamel defects and MIH in non-fluoridated and fluoridated communities. Eur J Paediatr Dent. 2005;6(4):209–12.
Banerjee M, Capozzoli M, McSweeney L, Sinha D. Beyond kappa: a review of interrater agreement measures. Can J Stat. 1999;27(1):3–23.
Bhaskar SA, Hegde S. Molar-incisor hypomineralization: prevalence, severity and clinical characteristics in 8- to 13-year-old children of Udaipur, India. J Indian Soc Pedod Prev Dent. 2014;32(4):322–9.
Biondi AM, Cortese SG, Martinez K, et al. Prevalence of molar incisor hypomineralization in the city of Buenos Aires. Acta Odontol Latinoam. 2011;24(1):81–5.
Biondi AM, Lopez Jordi Mdel C, Cortese SG, et al. Prevalence of molar-incisor hypomineralization (MIH) in children seeking dental care at the Schools of Dentistry of the University of Buenos Aires (Argentina) and University of la Republica (Uruguay). Acta Odontol Latinoam. 2012;25(2):224–30.
Brogardh-Roth S, Matsson L, Klingberg G. Molar-incisor hypomineralization and oral hygiene in 10-to-12-yr-old Swedish children born preterm. Eur J Oral Sci. 2011;119(1):33–9.
Calderara PC, Gerthoux PM, Mocarelli P, et al. The prevalence of molar incisor hypomineralisation (MIH) in a group of Italian school children. Eur J Paediatr Dent. 2005;6(2):79–83.
Cho SY, Ki Y, Chu V. Molar incisor hypomineralization in Hong Kong Chinese children. Int J Paediatr Dent. 2008;18(5):348–52.
Condo R, Perugia C, Maturo P, Docimo R. MIH: epidemiologic clinic study in paediatric patient. Oral Implantol (Rome). 2012;5(2–3):58–69.
Crombie F, Manton D, Kilpatrick N. Aetiology of molar-incisor hypomineralization: a critical review. Int J Paediatr Dent. 2009;19(2):73–83.
da Costa-Silva CM, Jeremias F, de Souza JF, et al. Molar incisor hypomineralization: prevalence, severity and clinical consequences in Brazilian children. Int J Paediatr Dent. 2010;20(6):426–34.
Demidenko E. Sample size determination for logistic regression revisited. Stat Med. 2007;26(18):3385–97.
Demidenko E. Sample size and optimal design for logistic regression with binary interaction. Stat Med. 2008;27(1):36–46.
Dietrich G, Sperling S, Hetzer G. Molar incisor hypomineralisation in a group of children and adolescents living in Dresden (Germany). Eur J Paediatr Dent. 2003;4(3):133–7.
Elfrink ME, Moll HA, Kiefte-de Jong JC, et al. Is maternal use of medicines during pregnancy associated with deciduous molar hypomineralisation in the offspring? A prospective, population-based study. Drug Saf. 2013;36(8):627–33.
Elfrink ME, Moll HA, Kiefte-de Jong JC, et al. Pre- and postnatal determinants of deciduous molar hypomineralisation in 6-year-old children. The generation R study. PLoS One. 2014;9(7):e91057.
Elfrink ME, Schuller AA, Weerheijm KL, Veerkamp JS. Hypomineralized second primary molars: prevalence data in Dutch 5-year-olds. Caries Res. 2008;42(4):282–5.
Elfrink ME, Ten Cate JM, Jaddoe VW, et al. Deciduous molar hypomineralization and molar incisor hypomineralization. J Dent Res. 2012;. doi:10.1177/0022034512440450.
Elfrink ME, Veerkamp JS, Aartman IH, Moll HA, Ten Cate JM. Validity of scoring caries and primary molar hypomineralization (DMH) on intraoral photographs. Eur Arch Paediatr Dent. 2009;10(Suppl 1):5–10.
Fagrell TG, Ludvigsson J, Ullbro C, Lundin SA, Koch G. Aetiology of severe demarcated enamel opacities–an evaluation based on prospective medical and social data from 1,7000 children. Swed Dent J. 2011;35(2):57–67.
Fteita D, Ali A, Alaluusua S. Molar-incisor hypomineralization (MIH) in a group of school-aged children in Benghazi, Libya. Eur Arch Paediatr Dent. 2006;7(2):92–5 doi:05.47 [pii].
Garcia-Margarit M, Catala-Pizarro M, Montiel-Company JM, Almerich-Silla JM. Epidemiologic study of molar-incisor hypomineralization in 8-year-old Spanish children. Int J Paediatr Dent. 2014;24(1):14–22.
Ghanim AM, Bagheri R, Golkari A, Manton D. Molar-incisor hypomineralisation: a prevalence study amongst primary schoolchildren of Shiraz, Iran. Eur Arch Paediatr Dent. 2013a;. doi:10.1007/s40368-013-0067-y.
Ghanim AM, Manton D, Marino R, Morgan M, Bailey D. Prevalence of demarcated hypomineralisation defects in second primary molars in Iraqi children. Int J Paediatr Dent. 2013b;23(1):48–55.
Ghanim AM, Morgan M, Marino R, Bailey D, Manton D. Molar-incisor hypomineralisation: prevalence and defect characteristics in Iraqi children. Int J Paediatr Dent. 2011;21(6):413–21.
Ghanim AM, Morgan MV, Marino RJ, Bailey DL, Manton DJ. Risk factors of hypomineralised second primary molars in a group of Iraqi school children. Eur Arch Paediatr Dent. 2012;13(3):111–8.
Ghanim AM, Marino R, Weerheijm K, Elfrink ME, Manton D. A practical method for use in epidemiologic studies of molar-incisor hypomineralisation and hypomineralised second primary molars. Eur Arch Paediatr Dent. 2015.
Groselj M, Jan J. Molar incisor hypomineralisation and dental caries among children in Slovenia. Eur J Paediatr Dent. 2013;14(3):241–5.
Heitmuller D, Thiering E, Hoffmann U, et al. Is there a positive relationship between molar incisor hypomineralisations and the presence of dental caries? Int J Paediatr Dent. 2013;23(2):116–24.
Hsieh FY, Bloch DA, Larsen MD. A simple method of sample size calculation for linear and logistic regression. Stat Med. 1998;17(14):1623–34.
Jälevik B. Prevalence and diagnosis of molar incisor hypomineralisation (MIH): a systematic review. Eur Arch Paediatr Dent. 2010;11(2):59–64.
Jälevik B, Klingberg G, Barregard L, Noren JG. The prevalence of demarcated opacities in permanent first molars in a group of Swedish children. Acta Odontol Scand. 2001;59(5):255–60.
Jankovic S, Ivanovic M, Davidovic B, Lecic J. Distribution and characteristics of molar-incisor hypomineralization. Vojnosanit Pregl. 2014;71(8):730–4.
Jasulaityte L, Veerkamp JS, Weerheijm KL. Molar incisor hypomineralization: review and prevalence data from the study of primary school children in Kaunas/Lithuania. Eur Arch Paediatr Dent. 2007;8(2):87–94.
Jasulaityte L, Weerheijm KL, Veerkamp JS. Prevalence of molar-incisor-hypomineralisation among children participating in the Dutch National Epidemiological Survey (2003). Eur Arch Paediatr Dent. 2008;9(4):218–23.
Jeremias F, de Souza JF, Silva CM, et al. Dental caries experience and molar incisor hypomineralization. Acta Odontol Scand. 2013;71(3–4):870–6.
Kar S, Sarkar S, Mukherjee A. Prevalence and Distribution of Developmental Defects of Enamel in the Primary Dentition of IVF Children of West Bengal. J Clin Diagn Res. 2014;8(7):ZC73–6.
Kemoli AM. Prevalence of molar incisor hypomineralisation in six to eight year-olds in two rural divisions in Kenya. East Afr Med J. 2008;85(10):514–9.
Koch G, Hallonsten AL, Ludvigsson N, et al. Epidemiologic study of idiopathic enamel hypomineralization in permanent teeth of Swedish children. Community Dent Oral Epidemiol. 1987;15(5):279–85.
Kohlboeck G, Heitmueller D, Neumann C, et al. Is there a relationship between hyperactivity/inattention symptoms and poor oral health? Results from the GINIplus and LISAplus study. Clin Oral Investig. 2013;17(5):1329–38.
Kuhnisch J, Heitmuller D, Thiering E, et al. Proportion and extent of manifestation of molar-incisor-hypomineralizations according to different phenotypes. J Public Health Dent. 2014;74(1):42–9.
Kukleva MP, Petrova SG, Kondeva VK, Nihtyanova TI. Molar incisor hypomineralisation in 7-to-14-year old children in Plovdiv, Bulgaria–an epidemiologic study. Folia Med (Plovdiv). 2008;50(3):71–5.
Kuscu OO, Caglar E, Aslan S, et al. The prevalence of molar incisor hypomineralization (MIH) in a group of children in a highly polluted urban region and a windfarm-green energy island. Int J Paediatr Dent. 2009;19(3):176–85.
Kuscu OO, Caglar E, Sandalli N. The prevalence and aetiology of molar-incisor hypomineralisation in a group of children in Istanbul. Eur J Paediatr Dent. 2008;9(3):139–44.
Leppaniemi A, Lukinmaa PL, Alaluusua S. Nonfluoride hypomineralizations in the permanent first molars and their impact on the treatment need. Caries Res. 2001;35(1):36–40.
Lygidakis NA, Dimou G, Briseniou E. Molar incisor hypomineralisation (MIH). Retrospective clinical study in Greek children. I. Prevalence and defect characteristics. Eur Arch Paediatr Dent. 2008;9(4):200–6.
Mahoney EK, Morrison DG. The prevalence of Molar-Incisor Hypomineralisation (MIH) in Wainuiomata children. N Z Dent J. 2009;105(4):121–7.
Mahoney EK, Morrison DG. Further examination of the prevalence of MIH in the Wellington region. N Z Dent J. 2011;107(3):79–84.
Martinez Gomez TP, Guinot Jimeno F, Bellet Dalmau LJ, Giner Tarrida L. Prevalence of molar-incisor hypomineralisation observed using transillumination in a group of children from Barcelona (Spain). Int J Paediatr Dent. 2012;22(2):100–9.
Mittal NP, Goyal A, Gauba K, Kapur A. Molar incisor hypomineralisation: prevalence and clinical presentation in school children of the northern region of India. Eur Arch Paediatr Dent. 2014;15(1):11–8.
Muratbegovic A, Markovic N, Ganibegovic Selimovic M. Molar incisor hypomineralisation in Bosnia and Herzegovina: aetiology and clinical consequences in medium caries activity population. Eur Arch Paediatr Dent. 2007;8(4):189–94.
Naing L, Winn T, Rusli BN. Practical Issues in calculating the sample size for prevalence studies. Arch Orofac Sci. 2006;1:9–14.
Ng JJ, Eu OC, Nair R, Hong CH. Prevalence of molar incisor hypomineralization (MIH) in Singaporean children. Int J Paediatr Dent. 2014;. doi:10.1111/ipd.12100.
Parikh DR, Ganesh M, Bhaskar V. Prevalence and characteristics of Molar Incisor Hypomineralisation (MIH) in the child population residing in Gandhinagar, Gujarat, India. Eur Arch Paediatr Dent. 2012;13(1):21–6.
Petrou MA, Giraki M, Bissar AR, et al. Prevalence of molar incisor hypomineralisation among school children in four German cities. Int J Paediatr Dent. 2014;24(6):434–40.
Pitiphat W, Luangchaichaweng S, Pungchanchaikul P, Angwaravong O, Chansamak N. Factors associated with molar incisor hypomineralization in Thai children. Eur J Oral Sci. 2014;122(4):265–70.
Power/Sample Size Calculation for Logistic Regression with Binary Covariate(s). http://www.dartmouth.edu/~eugened/power-samplesize.php. Accessed 8 Nov 2014.
Preusser SE, Ferring V, Wleklinski C, Wetzel WE. Prevalence and severity of molar incisor hypomineralization in a region of Germany – a brief communication. J Public Health Dent. 2007;67(3):148–50.
Shrestha R, Upadhaya S, Bajracharya M. Prevalence of molar incisor hypomineralisation among school children in Kavre. Kathmandu Univ Med J (KUMJ). 2014;12(45):38–42.
SIGN Criteria for assignment of levels of evidence and grades of recommendation http://www.bspd.co.uk/LinkClick.aspx?fileticket=K9eTCqw4wB4%3D&tabid=62. Accessed 2 Nov 2014.
Sonmez H, Yildirim G, Bezgin T. Putative factors associated with molar incisor hypomineralisation: an epidemiological study. Eur Arch Paediatr Dent. 2013;14(6):375–80.
Souza JF, Costa-Silva CM, Jeremias F, et al. Molar incisor hypomineralisation: possible aetiological factors in children from urban and rural areas. Eur Arch Paediatr Dent. 2012;13(4):164–70.
Souza JF, Jeremias F, Costa-Silva CM, et al. Aetiology of molar-incisor hypomineralisation (MIH) in Brazilian children. Eur Arch Paediatr Dent. 2013;. doi:10.1007/s40368-013-0054-3.
Soviero V, Haubek D, Trindade C, Da Matta T, Poulsen S. Prevalence and distribution of demarcated opacities and their sequelae in permanent 1st molars and incisors in 7 to 13-year-old Brazilian children. Acta Odontol Scand. 2009;67(3):170–5.
Weerheijm KL, Duggal M, Mejare I, et al. Judgement criteria for molar incisor hypomineralisation (MIH) in epidemiologic studies: a summary of the European meeting on MIH held in Athens, 2003. Eur J Paediatr Dent. 2003;4(3):110–3.
Weerheijm KL, Groen HJ, Beentjes VE, Poorterman JH. Prevalence of cheese molars in eleven-year-old Dutch children. ASDC J Dent Child. 2001;68(4):259–62.
Wogelius P, Haubek D, Poulsen S. Prevalence and distribution of demarcated opacities in permanent 1st molars and incisors in 6 to 8-year-old Danish children. Acta Odontol Scand. 2008;66(1):58–64.
Wuollet E, Laisi S, Salmela E, Ess A, Alaluusua S. Background factors of molar-incisor hypomineralization in a group of Finnish children. Acta Odontol Scand. 2014;72(8):963–9.
Zawaideh FI, Al-Jundi SH, Al-Jaljoli MH. Molar incisor hypomineralisation: prevalence in Jordanian children and clinical characteristics. Eur Arch Paediatr Dent. 2011;12(1):31–6.
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Elfrink, M.E.C., Ghanim, A., Manton, D.J. et al. Standardised studies on Molar Incisor Hypomineralisation (MIH) and Hypomineralised Second Primary Molars (HSPM): a need. Eur Arch Paediatr Dent 16, 247–255 (2015). https://doi.org/10.1007/s40368-015-0179-7
- Molar Incisor Hypomineralisation
- Hypomineralised Second Primary Molars
- Enamel hypomineralisation