Abstract
Purpose and background
Sentinel node biopsy (SNB) is routinely performed in patients with melanoma, breast cancer, gynaecological malignancies and oral cavity squamous cell carcinoma, but not for eyelid and conjunctival tumours. Several studies have demonstrated the feasibility and safety of the procedure, therefore this mini-review aimed to analyse the current knowledge about radioguided SNB in eyelid and conjunctival tumours.
Methods
We identified the most relevant clinical studies on SNB performed with radiotracers in eyelid and conjunctival tumours, providing technical and methodological information.
Results
We included a total of nine studies, employing 99mTc-sulphur colloid or albumin nanocolloids. In three studies, SPECT/CT was performed, which was helpful in defining the number and sites of the sentinel nodes and their relationship with adjacent anatomical structures. The sentinel node was identified in most studies (imaging detection rate from 82 to 100%). The positive rate for metastases ranged from 0 to 100%, leading to a change in management in case of positivity.
Conclusion
Radioguided SNB can be considered a feasible and safe procedure for conjunctival and eyelid malignancies, which could provide prognostic information for the treatment choice. Further confirmation in larger cohorts and longer follow-up periods is required to establish and validate this role. Finally, standardisation of the procedure would be useful.
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Data availability
All data supporting the findings of this study are available in the manuscript in the section “References”.
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All the authors contributed to the study conception and design. GP performed the literature search and review and drafted the first version of the manuscript. MGS, GB, TM and MMP provided substantial contribution to patient’s data. DDG, LZ, RG and TS critically revised the work for important intellectual content. All authors revised and approved the final version to be published.
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Pisano, G., Giancipoli, R.G., Sammarco, M.G. et al. Sentinel node mapping in conjunctival and eyelid malignancies: a mini-review. Clin Transl Imaging 11, 513–520 (2023). https://doi.org/10.1007/s40336-023-00557-5
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DOI: https://doi.org/10.1007/s40336-023-00557-5