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Towards quantitative small-animal imaging on hybrid PET/CT and PET/MRI systems

Clinical and Translational Imaging volume 8, pages 243–263 (2020)Cite this article

Abstract

Aim

Over the past two decades, innovations in small-animal positron emission tomography (PET) have reached an impressive level, which has brought countless opportunities to explore the major puzzles in biomedical research. It is a given that pairing information coming from different imaging modalities renders unprecedented knowledge and provides a great insight into various facets of biological systems, such as anatomy, function, physiology, and metabolism in animal models of human diseases, which are difficult to be beaten by standalone PET scanners. The development of bimodal and tri-modal imaging platforms with advanced software solutions dedicated for quantitative studies in small-animals has spurred academic and industrial interest. However, it is undisputed that the potential success of these scanners in filling the translational gap between human and animal findings, hinges to a great extent upon optimization and standardization of relevant parameters and acquisition protocols, which is often overlooked.

Methods

This article reviews the trends till 2020 in the field of preclinical PET imaging with emphasize on image reconstruction and quantitative corrections implemented on state-of-the-heart hybrid systems. First, the challenges, limitations, and benefits offered by multi-modality imaging systems are described and then, the most commonly used strategies, as well as novel techniques for image reconstruction and image corrections (attenuation, scattering, normalization, motion, and partial volume effect) are presented. The advantages and disadvantages of different methods are also discussed. We also briefly touch upon the factors that should be considered for reliable kinetic modeling and absolute quantitation in preclinical small animal research.

Conclusions

Multi-modality imaging has attracted a lot of research, particularly in the preclinical portfolio. Nevertheless, more research is still needed to optimize the conceptual design, reach the limits of quantitative imaging and implement standardized protocols for small-animal studies. Without any doubt, exploring the potential advantages of combined imaging units providing optimal image quality and reliable tools for quantification of biological parameters through standardized imaging protocols is one of the goals of translational research.

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Acknowledgements

This work was supported through grant No. 36950 from Tehran University of Medical Sciences and the Swiss National Science Foundation under grant SNSF 320030_176052.

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Authors and Affiliations

  1. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran

    Mahsa Amirrashedi & Mohammad Reza Ay

  2. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran

    Mahsa Amirrashedi & Mohammad Reza Ay

  3. Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, 1211, Geneva, Switzerland

    Habib Zaidi

  4. Geneva University Neurocenter, Geneva University, 1205, Geneva, Switzerland

    Habib Zaidi

  5. Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, 9700 RB, Groningen, Netherlands

    Habib Zaidi

  6. Department of Nuclear Medicine, University of Southern Denmark, 500, Odense, Denmark

    Habib Zaidi

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Amirrashedi, M., Zaidi, H. & Ay, M.R. Towards quantitative small-animal imaging on hybrid PET/CT and PET/MRI systems. Clin Transl Imaging 8, 243–263 (2020). https://doi.org/10.1007/s40336-020-00376-y

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