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Imaging gastrin-releasing peptide receptors (GRPRs) in prostate cancer

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Abstract

Despite significant advances in detection and treatment, prostate cancer (PC) remains the most common malignancy and a major cause of cancer death in men worldwide. Imaging is critically important for the diagnosis, staging, and management of men with prostate cancer (PC). The conventional imaging modalities have been employed for local and metastatic staging with limited performance. Whole-body positron emission tomography (PET) using prostate membrane antigen-based tracers is the most widely used in research and clinical applications in this scenario. However, other ways to image PC are available. Here, we review the clinical literatures on the use of gastrin-releasing peptide receptors (GRPRs) as targets for imaging patients with PC.

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Author information

Authors and Affiliations

  1. Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Stanford University, Stanford, CA, 94305, USA

    Lucia Baratto & Andrei Iagaru

  2. Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, Italy

    Riccardo Laudicella & Sergio Baldari

  3. Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

    Maria Picchio

Authors
  1. Lucia Baratto
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  2. Riccardo Laudicella
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  3. Maria Picchio
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  4. Sergio Baldari
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  5. Andrei Iagaru
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Contributions

LB: literature search, literature review, content planning, and manuscript writing and editing. RL: literature search, content planning, and manuscript writing and editing. MP, SB, and AI: content planning and editing.

Corresponding author

Correspondence to Riccardo Laudicella.

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Conflict of interest

L. Baratto, R. Laudicella, M. Picchio, S. Baldari, and A. Iagaru declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Baratto, L., Laudicella, R., Picchio, M. et al. Imaging gastrin-releasing peptide receptors (GRPRs) in prostate cancer. Clin Transl Imaging 7, 39–44 (2019). https://doi.org/10.1007/s40336-018-00308-x

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  • DOI: https://doi.org/10.1007/s40336-018-00308-x

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