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Early Vascular Aging in Obese Individuals with Low Cardiovascular Health

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Abstract

Introduction

The American Heart Association updated the original recommendations for cardiovascular health (CVH) promotion, defining the Life’s Essential 8 (L8).

Aim

the aim of this cross-sectional study was to compare vascular function, central hemodynamics and autonomic modulation in obese individuals with low and moderate CVH-L8.

Methods

Both sexes, aged 40–70 years and Body Mass Index ≥ 30 and < 40 kg/m2, were submitted to anthropometric and biochemical evaluation, assessment of heart rate variability, endothelial function by flow-mediated dilatation (FMD) and central parameters by oscillometry. The CVH-L8 score was determined using the eight metrics defined in the new classification.

Results

Patients (n = 82) were divided according to CVH-L8 classification: moderate group (score CVH-L8 ≥ 50 ≤ 79 points, n = 47) and low group (score CVH-L8 ≤ 49 points, n = 35). Peripheral (119 ± 10 vs 125 ± 15 mmHg, p = 0.048) and central (111 ± 10 vs 118 ± 15 mmHg; p = 0.016) systolic blood pressures and pulse wave velocity (PWV) adequacy (− 0.08 ± 0.34 vs 0.15 ± 0.42 m/s, p = 0.008) were significantly higher in low CVH-L8 group. Brachial FMD (9.24 ± 5.41 vs 6.79 ± 4.74%, p = 0.043) were lower in this same group. Only in the low CVH-L8 group low frequency/high frequency (LF/HF) ratio was significantly correlated with PWV (r = 0.338, p = 0.047) and atherogenic index of plasma with Framingham risk score (r = 0.446, p = 0.008), even after adjustment for age and sex.

Conclusion

In this sample of obese individuals, low CVH-L8 was associated with higher peripheral and central blood pressures, and evidence of early vascular aging with arterial stiffness and endothelial dysfunction.

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Author notes

  1. Mario Fritsch Neves

    Present address: Department of Clinical Medicine, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil

Authors and Affiliations

  1. Department of Clinical Medicine, State University of Rio de Janeiro (UERJ), Rio de Janeiro, Brazil

    Michelle Rabello Cunha & Samanta Mattos

  2. Department of Applied Nutrition, Nutrition Institute, State University of Rio de Janeiro, Rio de Janeiro, Brazil

    Márcia R. S. T. Klein

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  1. Michelle Rabello Cunha
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Corresponding author

Correspondence to Michelle Rabello Cunha.

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Funding Statement

The authors declare the following financial interests: Mario F Neves reports financial support was provided by Carlos Chagas Filho Foundation for Research Support of Rio de Janeiro State. Mario F Neves reports financial support was provided by National Council for Scientific and Technological Development.

Conflicts of interest/competing interest

The authors state that they have no conflicts of interest.

Data availability

The datasets of the current study are available from the corresponding author on reasonable request.

Author contributions

MRC: conceptualization, conducting the research, specifically performing the data collection, writing—original draft, interpretation and analysis of the data obtained. SM: conceptualization, conducting the research, specifically performing the data collection, interpretation and analysis of the data obtained. MRSTK: conceptualization, designed and performed the research, writing-original draft, interpretation and analysis of the data obtained, writing—review and editing. MFN: conceptualization, designed and performed the research, made the statistical analyses, interpretation and analysis of the data obtained, writing—review and editing. Acquisition of the financial support for the project leading to this publication.

Supplementary Information

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40292_2022_555_MOESM1_ESM.docx

Table S1. Metrics for quantitative assessment of cardiovascular health (CVH) according to the new American Heart Association classification - Life’s Essential 8 (DOCX 16 KB)

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Cunha, M.R., Mattos, S., Klein, M.R.S.T. et al. Early Vascular Aging in Obese Individuals with Low Cardiovascular Health. High Blood Press Cardiovasc Prev 30, 45–54 (2023). https://doi.org/10.1007/s40292-022-00555-0

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