Skip to main content
Log in

Modern Management of Hypertensive Emergencies

  • Review article
  • Published:
High Blood Pressure & Cardiovascular Prevention Aims and scope Submit manuscript

Abstract

Acute increases of blood pressure values are common causes of patients’ presentation to emergency departments, and their management represents a clinical challenge. They are usually described as ‘hypertensive crises’, ‘hypertensive urgencies’, terms that should be abandoned because they are misleading and inappropriate according to a recent task force of the European Society of Cardiology, which recommended to focus only on ‘hypertensive emergencies’. The latter can be esasily identified by using the Brain, Arteries, Retina, Kidney, and/or Heart (BARKH) strategy as herein described. Although current guidelines recommendations/suggestions for treatment of these patients are not evidence-based, owing to the lack of randomized clinical trials, improved understanding of the underlying pathophysiology has changed the approach to management of the patients presenting with hypertensive emergencies in recent years. Starting from these premises and a systematic review of the available studies graded by their quality, using the AHA class of recommendation/level of evidence grading, whenever possible, we herein present a novel a streamlined symptoms- and evidence-based algorithm for the assessment and management of patients with hypertensive emergencies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Maloberti A, Cassano G, Capsoni N, et al. Therapeutic approach to hypertension urgencies and emergencies in the emergency room. High Blood Press Cardiovasc Prev. 2018;25:177–89.

    Article  Google Scholar 

  2. Paini A, Aggiusti C, Bertacchini F, et al. Definitions and epidemiological aspects of hypertensive urgencies and emergencies. High Blood Press Cardiovasc Prev. 2018;25:241–4.

    Article  CAS  Google Scholar 

  3. van den Born BJH, Lip GYH, Brguljan-Hitij J, et al. ESC Council on hypertension position document on the management of hypertensive emergencies. Eur Hear J Cardiovasc Pharmacother. 2019;5:37–46.

    Article  Google Scholar 

  4. Rossi GP, Rossitto G, Maifredini C, et al. Management of hypertensive emergencies: a practical approach. Blood Press. 2021;30:208–19.

    Article  Google Scholar 

  5. Zampaglione B, Pascale C, Marchisio M, Cavallo-Perin P. Hypertensive urgencies and emergencies. Prevalence and clinical presentation. Hypertension. 1996;27:144–7.

    Article  CAS  Google Scholar 

  6. Kumar N, Simek S, Garg N, et al. Thirty-day readmissions after hospitalization for hypertensive emergency. Hypertension. 2019;73:60–7.

    Article  CAS  Google Scholar 

  7. Rossi GP, Seccia TM, Barton M, et al. Endothelial factors in the pathogenesis and treatment of chronic kidney disease Part I: General mechanisms: a joint consensus statement from the European Society of Hypertension Working Group on Endothelin and Endothelial Factors and The Japanese Society. J Hypertens. 2018;26:451–61.

    Article  Google Scholar 

  8. Rossi G, Seccia Y, Barton M, et al. Endothelial factors in the pathogenesis and treatment of chronic kidney disease part II: role in disease conditions: a joint consensus statement from the european society of hypertension working group on endothelin and endothelial factors and the Japanese. J Hypertens. 2018;36:426–71.

    Google Scholar 

  9. Rossi GP, Maiolino G, Zanchetta M, et al. The T(-786)C endothelial nitric oxide synthase genotype predicts cardiovascular mortality in high-risk patients. J Am Coll Cardiol. 2006;48:1166–74.

    Article  CAS  Google Scholar 

  10. Palatini P. ECG changes during minoxidil therapy. Arch Intern Med. 1981;141:817.

    Article  CAS  Google Scholar 

  11. Rossi GP, Seccia TM, Pessina AC. Clinical use of laboratory tests for the identification of secondary forms of arterial hypertension. Crit Rev Clin Lab Sci. 2007;44:1–85.

    Article  CAS  Google Scholar 

  12. Rossitto G, Cesari M, Ceolotto G, Maiolino G, Seccia TM, Rossi GP. Effects of mineralocorticoid and AT-1 receptor antagonism on the aldosterone—renin ratio (ARR) in primary aldosteronism patients (EMIRA Study): rationale and design. J Hum Hypertens. 2018;33:167–71.

    Article  Google Scholar 

  13. Azizi M, Sapoval M, Gosse P, et al. Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label, randomised controlled trial. Lancet. 2015;385:1957–65.

    Article  Google Scholar 

  14. Lip GY, Beevers M, Beevers G. The failure of malignant hypertension to decline: a survey of 24 years’ experience in a multiracial population in England. J Hypertens. 1994;12:1297–305.

    Article  CAS  Google Scholar 

  15. Van den Born B-JH, Koopmans RP, Groeneveld JO, van Montfrans GA. Ethnic Disparities in the Incidence, Presentation and Complications of Malignant Hypertension. J Hypertens 2006; 24: 2299–304.

  16. Salvetti M, Paini A, Colonetti E, et al. Hypertensive emergencies and urgencies: a single-centre experience in Northern Italy 2008–2015. J Hypertens. 2020;38:52–8.

    Article  CAS  Google Scholar 

  17. Grossman E, Nadler M, Sharabi Y, Thaler M, Shachar A, Shamiss A. Antianxiety treatment in patients with excessive hypertension. Am J Hypertens. 2005;18:1174–7.

    Article  CAS  Google Scholar 

  18. Wilson DJ, Wallin JD, Vlachakis ND, et al. Intravenous labetalol in the treatment of severe hypertension and hypertensive emergencies. Am J Med. 1983;75:95–102.

    Article  CAS  Google Scholar 

  19. Messerli FH. Haemodynamic effects of urapidil in arterial hypertension and congestive heart failure. Drugs. 1988;35(Suppl 6):70–3.

    Article  Google Scholar 

  20. Gierthmühlen J, Allardt A, Sawade M, Wasner G, Baron R. Role of sympathetic nervous system in activity-induced cerebral perfusion. J Neurol. 2010;257:1798–805.

    Article  Google Scholar 

  21. Miller J, Suchdev K, Jayaprakash N, et al. New developments in hypertensive encephalopathy. Curr Hypertens Rep. 2018;20:13.

    Article  Google Scholar 

  22. Narbone MC, Musolino R, Granata F, Mazzù I, Abbate M, Ferlazzo E. PRES: posterior or potentially reversible encephalopathy syndrome? Neurol Sci. 2006;27:187–9.

    Article  CAS  Google Scholar 

  23. Fox L, Cohney S, Kausman J, et al. Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand. Intern Med J. 2018;48:624–36.

    Article  CAS  Google Scholar 

  24. Webster K, Fishburn S, Maresh M, Findlay SC, Chappell LC. Diagnosis and management of hypertension in pregnancy: Summary of updated NICE guidance. BMJ. 2019;366:1–8.

    Google Scholar 

  25. ACOG Committee on Obstetric Practice. ACOG Practice bulletin: diagnosis and management of preeclampsia and eclampsia. Obstet Gynecol. 2002;77:67–75.

    Google Scholar 

  26. Williams B, Mancia G, Spiering W, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J. 2018;39:3021–104.

    Article  Google Scholar 

  27. Wacker J, Werner P, Walter-Sack I, Bastert G. Treatment of hypertension in patients with pre-eclampsia: a prospective parallel-group study comparing dihydralazine with urapidil. Nephrol Dial Transplant. 1998;13:318–25.

    Article  CAS  Google Scholar 

  28. Wacker JR, Wagner BK, Briese V, et al. Antihypertensive therapy in patients with pre-eclampsia: a prospective randomised multicentre study comparing dihydralazine with urapidil. Eur J Obstet Gynecol Reprod Biol. 2006;127:160–5.

    Article  CAS  Google Scholar 

  29. Olsson C, Thelin S, Ståhle E, Ekbom A, Granath F. Thoracic aortic aneurysm and dissection: increasing prevalence and improved outcomes reported in a nationwide population-based study of more than 14,000 cases from 1987 to 2002. Circulation. 2006;114:2611–8.

    Article  Google Scholar 

  30. Howard DPJ, Banerjee A, Fairhead JF, et al. Population-based study of incidence and outcome of acute aortic dissection and premorbid risk factor control: 10-year results from the Oxford Vascular Study. Circulation. 2013;127:2031–7.

    Article  Google Scholar 

  31. Clouse WD, Hallett JW, Schaff HV, et al. Acute aortic dissection: population-based incidence compared with degenerative aortic aneurysm rupture. Mayo Clin Proc. 2004;79:176–80.

    Article  Google Scholar 

  32. Collet J-P, Thiele H, Barbato E, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 2020;2020:1–79.

    Google Scholar 

  33. Yang W, Zhou Y-J, Fu Y, et al. A multicenter, randomized, trial comparing urapidil and nitroglycerin in multifactor heart failure in the elderly. Am J Med Sci. 2015;350:109–15.

    Article  Google Scholar 

  34. Tauzin-Fin P, Sesay M, Gosse P, Ballanger P. Effects of perioperative alpha1 block on haemodynamic control during laparoscopic surgery for phaeochromocytoma. Br J Anaesth. 2004;92:512–7.

    Article  CAS  Google Scholar 

  35. Gosse P, Tauzin-Fin P, Sesay M-B, Sautereau A, Ballanger P. Preparation for surgery of phaeochromocytoma by blockade of alpha-adrenergic receptors with urapidil: what dose? J Hum Hypertens. 2009;23:605–9.

    Article  CAS  Google Scholar 

  36. Habbe N, Ruger F, Bojunga J, Bechstein WO, Holzer K. Urapidil in the preoperative treatment of pheochromocytomas: a safe and cost-effective method. World J Surg. 2013;37:1141–6.

    Article  Google Scholar 

  37. Reinisch A, Holzer K, Bojunga J, Bechstein WO, Habbe N. Patient’s safety and feasibility of intravenous urapidil in the pretreatment of pheochromocytoma patients in a normal ward setting—an analysis of 20 consecutive cases. Acta Endocrinol (Buchar), 2016.

  38. Tauzin-Fin P, Barrucand K, Sesay M, et al. Peri-operative management of pheochromocytoma with intravenous urapidil to prevent hemodynamic instability: a 17-year experience. J Anaesthesiol Clin Pharmacol. 2020;36:49–54.

    Article  CAS  Google Scholar 

  39. Kumar A, Gupta N, Gupta A. Urapidil in the Preoperative treatment of pheochromocytoma: how safe is it? J Anaesthesiol Clin Pharmacol. 2020;36:55–6.

    Article  Google Scholar 

  40. Bravo EL, Fouad-Tarazi F, Rossi G, et al. A reevaluation of the hemodynamics of pheochromocytoma. Hypertension. 1990;15:I128–31.

    Article  CAS  Google Scholar 

  41. Torresan F, Rossitto G, Bisogni V, et al. Resolution of drug-resistant hypertension by adrenal vein sampling-guided adrenalectomy: a proof-of-concept study. Clin Sci. 2020;134:1265–78.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Gian Paolo Rossi.

Ethics declarations

Sources of funding

This study was supported by the following Grants: European Cooperation in Science and Technology ADMIRE BM1301, European Cooperation in Science and Technology ENSAT-HT 633983 to GPR, Italian Society of Hypertension (SIIA), and FORICA (The Foundation for advanced Research In Hypertension and Cardiovascular diseases) to GPR, and University of Padua DOR2045593/20 to TMS.

Disclosure Summary

The authors have nothing to disclose.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rossi, G.P., Rossitto, G., Maifredini, C. et al. Modern Management of Hypertensive Emergencies. High Blood Press Cardiovasc Prev 29, 33–40 (2022). https://doi.org/10.1007/s40292-021-00487-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40292-021-00487-1

Keywords

Navigation