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Association Between Central-Peripheral Blood Pressure Amplification and Structural and Functional Cardiac Properties in Children, Adolescents, and Adults: Impact of the Amplification Parameter, Recording System and Calibration Scheme

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Abstract

Introduction

Systolic blood pressure (SBPA) and pulse pressure amplification (PPA) were quantified using different methodological and calibration approaches to analyze (1) the association and agreement between different SBPA and PPA parameters and (2) the association between these SBPA and PPA parameters and left ventricle (LV) and atrium (LA) structural and functional characteristics.

Methods

In 269 healthy subjects, LV and LA parameters were echocardiography-derived. SBPA and PPA parameters were quantified using: (1) different equations (n = 9), (2) methodological approaches (n = 3): brachial sub-diastolic (Mobil-O-Graph®) and supra-systolic oscillometry (Arteriograph®) and aortic diameter waveform re-calibration (RCD; ultrasonography), and (3) using three different calibration schemes: systo-diastolic (SD), calculated mean (CM) and oscillometric mean (OscM).

Results

SBPA and PPA parameters obtained with different equations, techniques, and calibration schemes show a highly variable association level (negative, non-significant, and/or positive) among them. The association between SBPA and PPA with cardiac parameters were highly variable (negative, non-significant, or positive associations). Differences in BPA parameter data between approaches were more sensitive to the calibration method than to the device used. Both, SBPA and PPA obtained with brachial sub-diastolic technique and calibrated to CM or OscM showed higher levels of association with LV and LA structural characteristics.

Conclusions

Our data show that many of the parameters that assume to quantify the same phenomenon of BPA are not related to each other in the different age groups. Both, SBPA and PPA obtained with brachial sub-diastolic technique and calibrated to CM or OscM showed higher levels of association with LV and LA structural characteristics.

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Acknowledgements

Special thanks to Silvina Schang for your technical assistance. We thank the children and adolescents (and their families), and adults for their participation in the study. This study (data and statistical analysis software) was partially supported by Agencia Nacional de Investigación e Innovación (ANII) and extrabudgetary funds provided by CUiiDARTE.

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  1. Alejandro Díaz and Daniel Bia contributed equally.

Authors and Affiliations

  1. Instituto de Investigación en Ciencias de la Salud, UNICEN-CCT CONICET, 4 de Abril 618, 7000, Tandil, Buenos Aires Province, Argentina

    Alejandro Díaz

  2. Departamento de Fisiología, Facultad de Medicina, Centro Universitario de Investigación, Innovación y Diagnóstico Arterial (CUiiDARTE), Universidad de la República, General Flores 2125, 11800, Montevideo, Uruguay

    Daniel Bia

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Díaz, A., Bia, D. Association Between Central-Peripheral Blood Pressure Amplification and Structural and Functional Cardiac Properties in Children, Adolescents, and Adults: Impact of the Amplification Parameter, Recording System and Calibration Scheme. High Blood Press Cardiovasc Prev 28, 185–249 (2021). https://doi.org/10.1007/s40292-021-00440-2

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